7CP0
| Crystal Structure of double mutant Y115E Y117E human Secretory Glutaminyl Cyclase | Descriptor: | 1,2-ETHANEDIOL, Glutaminyl-peptide cyclotransferase, SULFATE ION, ... | Authors: | Dileep, K.V, Ihara, K, Sakai, N, Shirozu, M, Zhang, K.Y.J. | Deposit date: | 2020-08-05 | Release date: | 2021-01-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Piperidine-4-carboxamide as a new scaffold for designing secretory glutaminyl cyclase inhibitors. Int.J.Biol.Macromol., 170, 2020
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7YPJ
| Spiral pentamer of the substrate-free Lon protease with a S678A mutation | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease | Authors: | Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I. | Deposit date: | 2022-08-03 | Release date: | 2023-10-25 | Last modified: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
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7YUU
| MtaLon-ADP for the spiral oligomers of trimer | Descriptor: | Lon protease | Authors: | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | Deposit date: | 2022-08-17 | Release date: | 2023-10-25 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (5.8 Å) | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
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7YPI
| Spiral hexamer of the substrate-free Lon protease with a Y224S mutation | Descriptor: | Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | Authors: | Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I. | Deposit date: | 2022-08-03 | Release date: | 2023-10-25 | Last modified: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
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7YUV
| MtaLon-ADP for the spiral oligomers of tetramer | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease | Authors: | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | Deposit date: | 2022-08-17 | Release date: | 2023-10-25 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
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7YUH
| MtaLon-Apo for the spiral oligomers of trimer | Descriptor: | Lon protease | Authors: | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | Deposit date: | 2022-08-17 | Release date: | 2023-10-25 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
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7YUW
| MtaLon-ADP for the spiral oligomers of pentamer | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease | Authors: | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | Deposit date: | 2022-08-18 | Release date: | 2023-10-25 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
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7YUP
| MtaLon-Apo for the spiral oligomers of pentamer | Descriptor: | Lon protease | Authors: | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | Deposit date: | 2022-08-17 | Release date: | 2023-10-25 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
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7YPH
| Open-spiral pentamer of the substrate-free Lon protease with a Y224S mutation | Descriptor: | Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | Authors: | Li, S, Hsieh, K.Y, Kuo, C.I, Lee, S.H, Ho, M.R, Wang, C.H, Zhang, K, Chang, C.I. | Deposit date: | 2022-08-03 | Release date: | 2023-10-25 | Last modified: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (3.68 Å) | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
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7YUT
| MtaLon-Apo for the spiral oligomers of hexamer | Descriptor: | Lon protease | Authors: | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | Deposit date: | 2022-08-17 | Release date: | 2023-10-25 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
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7YUM
| MtaLon-Apo for the spiral oligomers of tetramer | Descriptor: | Lon protease | Authors: | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | Deposit date: | 2022-08-17 | Release date: | 2023-10-25 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023
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7CUQ
| 2.55-Angstrom Cryo-EM structure of Cytochrome bo3 from Escherichia coli in Native Membrane | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, COPPER (II) ION, Cytochrome bo(3) ubiquinol oxidase subunit 1, ... | Authors: | Li, J, Han, L, Gennis, R.B, Zhu, J.P, Zhang, K. | Deposit date: | 2020-08-24 | Release date: | 2021-08-25 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.64 Å) | Cite: | Cryo-EM structures of Escherichia coli cytochrome bo3 reveal bound phospholipids and ubiquinone-8 in a dynamic substrate binding site. Proc.Natl.Acad.Sci.USA, 118, 2021
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7CUW
| Ubiquinol Binding Site of Cytochrome bo3 from Escherichia coli | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, COPPER (II) ION, Cytochrome bo(3) ubiquinol oxidase subunit 1, ... | Authors: | Li, J, Han, L, Gennis, R.B, Zhu, J.P, Zhang, K. | Deposit date: | 2020-08-25 | Release date: | 2021-08-25 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.63 Å) | Cite: | Cryo-EM structures of Escherichia coli cytochrome bo3 reveal bound phospholipids and ubiquinone-8 in a dynamic substrate binding site. Proc.Natl.Acad.Sci.USA, 118, 2021
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7CUB
| 2.55-Angstrom Cryo-EM structure of Cytochrome bo3 from Escherichia coli in Native Membrane | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, COPPER (II) ION, Cytochrome bo(3) ubiquinol oxidase subunit 1, ... | Authors: | Li, J, Han, L, Gennis, R.B, Zhu, J.P, Zhang, K. | Deposit date: | 2020-08-22 | Release date: | 2021-08-25 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.55 Å) | Cite: | Cryo-EM structures of Escherichia coli cytochrome bo3 reveal bound phospholipids and ubiquinone-8 in a dynamic substrate binding site. Proc.Natl.Acad.Sci.USA, 118, 2021
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8K8V
| CryoEM structure of LonC protease hepatmer, apo state | Descriptor: | PHOSPHATE ION, endopeptidase La | Authors: | Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S. | Deposit date: | 2023-07-31 | Release date: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (2.75 Å) | Cite: | Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis Fundam Res, 2024
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8K8Z
| CryoEM structure of LonC protease hexamer in presence of AGS | Descriptor: | Monothiophosphate, endopeptidase La | Authors: | Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S. | Deposit date: | 2023-07-31 | Release date: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (2.83 Å) | Cite: | Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis Fundam Res, 2024
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8K92
| CryoEM structure of LonC S582A hexamer with Lysozyme | Descriptor: | Endopeptidase La, Monothiophosphate | Authors: | Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S. | Deposit date: | 2023-07-31 | Release date: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (3.31 Å) | Cite: | Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis Fundam Res, 2024
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8K95
| CryoEM structure of LonC protease open Hexamer, AGS | Descriptor: | Monothiophosphate, endopeptidase La | Authors: | Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S. | Deposit date: | 2023-07-31 | Release date: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis Fundam Res, 2024
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8K91
| CryoEM structure of LonC S582A hepatmer with Lysozyme | Descriptor: | Endopeptidase La, Monothiophosphate | Authors: | Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S. | Deposit date: | 2023-07-31 | Release date: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (3.03 Å) | Cite: | Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis Fundam Res, 2024
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8K8Y
| CryoEM structure of LonC heptamer in presence of AGS | Descriptor: | Monothiophosphate, endopeptidase La | Authors: | Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S. | Deposit date: | 2023-07-31 | Release date: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (2.54 Å) | Cite: | Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis Fundam Res, 2024
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8K96
| CryoEM structure of LonC protease hepatmer with Bortezomib | Descriptor: | N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE, PHOSPHATE ION, endopeptidase La | Authors: | Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S. | Deposit date: | 2023-07-31 | Release date: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis Fundam Res, 2024
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8K97
| CryoEM structure of LonC protease hexamer with Bortezomib | Descriptor: | N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE, PHOSPHATE ION, endopeptidase La | Authors: | Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S. | Deposit date: | 2023-07-31 | Release date: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (2.73 Å) | Cite: | Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis Fundam Res, 2024
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8K90
| CryoEM structure of LonC protease open pentamer in presence of AGS | Descriptor: | Monothiophosphate, endopeptidase La | Authors: | Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S. | Deposit date: | 2023-07-31 | Release date: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (3.43 Å) | Cite: | Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis Fundam Res, 2024
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8K93
| CryoEM structure of LonC protease S582A open hexamer with lysozyme | Descriptor: | Endopeptidase La, Monothiophosphate | Authors: | Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S. | Deposit date: | 2023-07-31 | Release date: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (3.23 Å) | Cite: | Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis Fundam Res, 2024
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8K8W
| CryoEM structure of LonC protease open hexamer, apo state | Descriptor: | endopeptidase La | Authors: | Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S. | Deposit date: | 2023-07-31 | Release date: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (3.46 Å) | Cite: | Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis Fundam Res, 2024
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