8K97

CryoEM structure of LonC protease hexamer with Bortezomib

Summary for 8K97

• Entry DOI: 10.2210/pdb8k97/pdb
• EMDB information: 36977
• Descriptor: endopeptidase La, PHOSPHATE ION, N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE (3 entities in total)
• Functional Keywords: lon proteases, chaperone, hexamer, inhibitor
• Biological source: Meiothermus taiwanensis
• Total number of polymer chains: 6
• Total formula weight: 486225.36

Authors

Li, M.,Hsieh, K.,Liu, H.,Zhang, S.,Gao, Y.,Gong, Q.,Zhang, K.,Chang, C.,Li, S. (deposition date: 2023-07-31, release date: 2024-08-07, Last modification date: 2025-07-02)

• Primary citation: Li, M.,Liu, H.,Hsieh, K.Y.,Zhang, S.,Gao, Y.,Gong, Q.,Zhang, K.,Chang, C.I.,Li, S.; Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis; Fundam Res, 2024; DOI: 10.1016/j.fmre.2024.02.020

Experimental method

ELECTRON MICROSCOPY (2.73 Å)