4OAU
 
 | | Complete human RNase L in complex with biological activators. | | Descriptor: | 2-5A-dependent ribonuclease, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Han, Y, Donovan, J, Rath, S, Whitney, G, Chitrakar, A, Korennykh, A. | | Deposit date: | 2014-01-06 | | Release date: | 2014-03-12 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response.
Science, 343, 2014
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6CNC
 | | Yeast RNA polymerase III open complex | | Descriptor: | DNA (71-MER), DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, ... | | Authors: | Han, Y, He, Y. | | Deposit date: | 2018-03-08 | | Release date: | 2018-08-22 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Structural visualization of RNA polymerase III transcription machineries.
Cell Discov, 4, 2018
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6CNF
 | | Yeast RNA polymerase III elongation complex | | Descriptor: | DNA (79-MER), DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, ... | | Authors: | Han, Y, He, Y. | | Deposit date: | 2018-03-08 | | Release date: | 2018-08-22 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | Structural visualization of RNA polymerase III transcription machineries.
Cell Discov, 4, 2018
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8V22
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2MNY
 | | NMR Structure of KDM5B PHD1 finger | | Descriptor: | Lysine-specific demethylase 5B, ZINC ION | | Authors: | Zhang, Y, Yang, H.R, Guo, X, Rong, N.Y, Song, Y.J, Xu, Y.W, Lan, W.X, Xu, Y.H, Cao, C. | | Deposit date: | 2014-04-16 | | Release date: | 2014-08-06 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B.
Protein Cell, 5, 2014
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2MNZ
 | | NMR Structure of KDM5B PHD1 finger in complex with H3K4me0(1-10aa) | | Descriptor: | H3K4me0, Lysine-specific demethylase 5B, ZINC ION | | Authors: | Zhang, Y, Yang, H.R, Guo, X, Rong, N.Y, Song, Y.J, Xu, Y.W, Lan, W.X, Xu, Y.H, Cao, C. | | Deposit date: | 2014-04-16 | | Release date: | 2014-08-06 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B.
Protein Cell, 5, 2014
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9J6O
 | | Crystal Structure of bromodomain of human CBP in complex with the inhibitor CZL-046 | | Descriptor: | (3~{S},5~{S})-1-[3,4-bis(fluoranyl)phenyl]-5-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-(4-methoxycyclohexyl)benzimidazol-2-yl]-3-fluoranyl-pyrrolidin-2-one, CHLORIDE ION, CREB-binding protein | | Authors: | Zhang, Y, Zhang, C, Chen, Z, Yang, H, Huang, X, Li, Y, Xu, Y. | | Deposit date: | 2024-08-16 | | Release date: | 2024-10-16 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.67 Å) | | Cite: | Discovery of CZL-046 with an ( S )-3-Fluoropyrrolidin-2-one Scaffold as a p300 Bromodomain Inhibitor for the Treatment of Multiple Myeloma.
J.Med.Chem., 67, 2024
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2MN6
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2MN7
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7F7I
 | | Stapled Peptide Inhibitor in complex with PSD95 GK domain | | Descriptor: | ACE-ARG-ILE-ARG-ARG-ASP-GLU-TYR-LEU-LYZ-ALA-ILE-GLN-NH2, Disks large homolog 4 | | Authors: | Shang, Y, Huang, X, Li, X, Zhang, M. | | Deposit date: | 2021-06-29 | | Release date: | 2022-04-06 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.595 Å) | | Cite: | Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain.
Rsc Chem Biol, 2, 2021
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2M1Z
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7F7G
 | | a linear Peptide Inhibitors in complex with GK domain | | Descriptor: | DLG4 GK domain, UNK-ARG-ILE-ARG-ARG-ASP-GLU-TYR-LEU-LYS-ALA-ILE-GLN-UNK | | Authors: | Shang, Y, Huang, X, Li, X, Zhang, M. | | Deposit date: | 2021-06-29 | | Release date: | 2022-02-23 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.446 Å) | | Cite: | Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain.
Rsc Chem Biol, 2, 2021
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1FBC
 | | CRYSTALLOGRAPHIC STUDIES OF THE CATALYTIC MECHANISM OF THE NEUTRAL FORM OF FRUCTOSE-1,6-BISPHOSPHATASE | | Descriptor: | 2,5-anhydro-1,6-di-O-phosphono-D-glucitol, FRUCTOSE 1,6-BISPHOSPHATASE, MAGNESIUM ION | | Authors: | Zhang, Y, Liang, J.-Y, Huang, S, Ke, H, Lipscomb, W.N. | | Deposit date: | 1992-10-14 | | Release date: | 1993-10-31 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystallographic studies of the catalytic mechanism of the neutral form of fructose-1,6-bisphosphatase.
Biochemistry, 32, 1993
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1FBG
 | | CRYSTALLOGRAPHIC STUDIES OF THE CATALYTIC MECHANISM OF THE NEUTRAL FORM OF FRUCTOSE-1,6-BISPHOSPHATASE | | Descriptor: | 2,5-anhydro-1,6-di-O-phosphono-D-mannitol, FRUCTOSE 1,6-BISPHOSPHATASE, MANGANESE (II) ION | | Authors: | Zhang, Y, Liang, J.-Y, Huang, S, Ke, H, Lipscomb, W.N. | | Deposit date: | 1992-10-16 | | Release date: | 1993-10-31 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystallographic studies of the catalytic mechanism of the neutral form of fructose-1,6-bisphosphatase.
Biochemistry, 32, 1993
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8J0T
 | | Cryo-EM structure of Mycobacterium tuberculosis ATP synthase in the apo-form | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... | | Authors: | Zhang, Y, Lai, Y, Liu, F, Rao, Z, Gong, H. | | Deposit date: | 2023-04-11 | | Release date: | 2024-05-22 | | Last modified: | 2024-08-21 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Inhibition of M. tuberculosis and human ATP synthase by BDQ and TBAJ-587.
Nature, 631, 2024
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1FNL
 | | CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF A HUMAN FCGRIII | | Descriptor: | LOW AFFINITY IMMUNOGLOBULIN GAMMA FC REGION RECEPTOR III-B, MERCURY (II) ION | | Authors: | Zhang, Y, Boesen, C.C, Radaev, S, Brooks, A.G, Fridman, W.H, Sautes-Fridman, C, Sun, P.D. | | Deposit date: | 2000-08-22 | | Release date: | 2000-11-22 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of the extracellular domain of a human Fc gamma RIII.
Immunity, 13, 2000
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9K48
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8HPB
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8HQB
 | | NMR Structure of OsCIE1-Ubox | | Descriptor: | U-box domain-containing protein 12 | | Authors: | Zhang, Y, Yu, C.Z, Lan, W.X. | | Deposit date: | 2022-12-13 | | Release date: | 2023-12-20 | | Last modified: | 2024-06-12 | | Method: | SOLUTION NMR | | Cite: | Release of a ubiquitin brake activates OsCERK1-triggered immunity in rice.
Nature, 629, 2024
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8CZJ
 | | A bacteria Zrt/Irt-like protein in the apo state | | Descriptor: | Putative membrane protein, SULFATE ION, [(Z)-octadec-9-enyl] (2R)-2,3-bis(oxidanyl)propanoate | | Authors: | Zhang, Y, Hu, J. | | Deposit date: | 2022-05-24 | | Release date: | 2023-02-22 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.751 Å) | | Cite: | Structural insights into the elevator-type transport mechanism of a bacterial ZIP metal transporter.
Nat Commun, 14, 2023
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1NA4
 | | The structure of immature Yellow Fever virus particle | | Descriptor: | major envelope protein E | | Authors: | Zhang, Y, Corver, J, Chipman, P.R, Lenches, E, Zhang, W, Pletnev, S.V, Sedlak, D, Baker, T.S, Strauss, J.H, Kuhn, R.J, Rossmann, M.G. | | Deposit date: | 2002-11-26 | | Release date: | 2003-12-09 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY | | Cite: | Structures of immature flavivirus particles
EMBO J., 22, 2003
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1N6G
 | | The structure of immature Dengue-2 prM particles | | Descriptor: | major envelope protein E | | Authors: | Zhang, Y, Corver, J, Chipman, P.R, Zhang, W, Pletnev, S.V, Sedlak, D, Baker, T.S, Strauss, J.H, Kuhn, R.J, Rossmann, M.G. | | Deposit date: | 2002-11-10 | | Release date: | 2003-06-03 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (16 Å) | | Cite: | Structures of Immature flavivirus particles
EMBO J., 22, 2003
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9CIL
 | | Crystal structure of Staphylococcal nuclease variant Delta+PHS T41V/S59A at cryogenic temperature | | Descriptor: | CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease | | Authors: | Zhang, Y, Schlessman, J.L, Siegler, M.A, Garcia-Moreno E, B. | | Deposit date: | 2024-07-03 | | Release date: | 2024-08-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of Staphylococcal nuclease variant Delta+PHS T41V/S59A at cryogenic temperature
To Be Published
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9CIK
 | | Crystal structure of Staphylococcal nuclease variant Delta+PHS V23R/L36D at cryogenic temperature | | Descriptor: | CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease | | Authors: | Zhang, Y, Schlessman, J.L, SIegler, M.A, Garcia-Moreno E, B. | | Deposit date: | 2024-07-03 | | Release date: | 2024-08-07 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Crystal structure of Staphylococcal nuclease variant Delta+PHS V23R/L36D at cryogenic temperature
To Be Published
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9CII
 | | Crystal structure of Staphylococcal nuclease variant Delta+PHS V23D/L36R at cryogenic temperature | | Descriptor: | CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease | | Authors: | Zhang, Y, Schlessman, J.L, Robinson, A.C, Garcia-Moreno E, B. | | Deposit date: | 2024-07-03 | | Release date: | 2024-08-07 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Crystal structure of Staphylococcal nuclease variant Delta+PHS V23D/L36R at cryogenic temperature
To Be Published
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