1W39
| Crystal structure of an artificial top component of turnip yellow mosaic virus | 分子名称: | TURNIP YELLOW MOSAIC VIRUS EMPTY CAPSID | 著者 | van Roon, A.M.M, Bink, H.H.J, Plaisier, J.R, Pleij, C.W.A, Abrahams, J.P, Pannu, N.S. | 登録日 | 2004-07-14 | 公開日 | 2004-08-16 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.75 Å) | 主引用文献 | Crystal Structure of an Empty Capsid of Turnip Yellow Mosaic Virus. J.Mol.Biol., 341, 2004
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5O4W
| Protein structure determination by electron diffraction using a single three-dimensional nanocrystal | 分子名称: | Lysozyme C | 著者 | Clabbers, M.T.B, van Genderen, E, Wan, W, Wiegers, E.L, Gruene, T, Abrahams, J.P. | 登録日 | 2017-05-31 | 公開日 | 2017-08-23 | 最終更新日 | 2024-01-17 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (2.11 Å) | 主引用文献 | Protein structure determination by electron diffraction using a single three-dimensional nanocrystal. Acta Crystallogr D Struct Biol, 73, 2017
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3ZU1
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7LJM
| Structure of the Salmonella enterica CD-NTase CdnD in complex with GTP | 分子名称: | CD-NTase, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION | 著者 | Govande, A, Lowey, B, Eaglesham, J.B, Whiteley, A.W, Kranzusch, P.J. | 登録日 | 2021-01-29 | 公開日 | 2021-06-02 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Molecular basis of CD-NTase nucleotide selection in CBASS anti-phage defense. Cell Rep, 35, 2021
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7LJL
| Structure of the Enterobacter cloacae CD-NTase CdnD in complex with ATP | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Cyclic AMP-AMP-GMP synthase, ... | 著者 | Govande, A, Lowey, B, Eaglesham, J.B, Whiteley, A.W, Kranzusch, P.J. | 登録日 | 2021-01-29 | 公開日 | 2021-06-02 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Molecular basis of CD-NTase nucleotide selection in CBASS anti-phage defense. Cell Rep, 35, 2021
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7LJN
| Structure of the Bradyrhizobium diazoefficiens CD-NTase CdnG in complex with GTP | 分子名称: | CD-NTase, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION | 著者 | Govande, A, Lowey, B, Eaglesham, J.B, Whiteley, A.T, Kranzusch, P.J. | 登録日 | 2021-01-29 | 公開日 | 2021-06-02 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Molecular basis of CD-NTase nucleotide selection in CBASS anti-phage defense. Cell Rep, 35, 2021
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5A09
| Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor | 分子名称: | 2-[(4R)-4-(4-cyanophenyl)-5-ethanoyl-6-methyl-2-oxidanylidene-1-[3-(trifluoromethyl)phenyl]-4H-pyrimidin-3-yl]ethanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, NEUTROPHIL ELASTASE, ... | 著者 | vonNussbaum, F, Li, V.M.-J, Allerheiligen, S, Anlauf, S, Baerfacker, L, Bechem, M, Delbeck, M, Fitzgerald, M.F, Gerisch, M, Gielen-Haertwig, H, Haning, H, Karthaus, D, Lang, D, Lustig, K, Meibom, D, Mittendorf, J, Rosentreter, U, Schaefer, M, Schaefer, S, Schamberger, J, Telan, L.A, Tersteegen, A. | 登録日 | 2015-04-17 | 公開日 | 2015-08-19 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases. ChemMedChem, 10, 2015
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1UZ6
| anti-Lewis X Fab fragment uncomplexed | 分子名称: | IGG FAB (IGG3, KAPPA) HEAVY CHAIN 291-2G3-A, KAPPA) LIGHT CHAIN 291-2G3-A, ... | 著者 | Van Roon, A.M.M, Pannu, N.S, De Vrind, J.P.M, Hokke, C.H, Deelder, A.M, Van Der marel, G.A, Van Boom, J.H, Abrahams, J.P. | 登録日 | 2004-03-05 | 公開日 | 2004-06-29 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structure of an Anti-Lewis X Fab Fragment in Complex with its Lewis X Antigen Structure, 12, 2004
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5A0B
| Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor | 分子名称: | (4R)-4-(4-cyanophenyl)-6-methyl-2-oxidanylidene-3-[2-oxidanylidene-2-(4-propan-2-ylpiperazin-1-yl)ethyl]-1-[3-(trifluoromethyl)phenyl]-4H-pyrimidine-5-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... | 著者 | vonNussbaum, F, Li, V.M.-J, Allerheiligen, S, Anlauf, S, Baerfacker, L, Bechem, M, Delbeck, M, Fitzgerald, M.F, Gerisch, M, Gielen-Haertwig, H, Haning, H, Karthaus, D, Lang, D, Lustig, K, Meibom, D, Mittendorf, J, Rosentreter, U, Schaefer, M, Schaefer, S, Schamberger, J, Telan, L.A, Tersteegen, A. | 登録日 | 2015-04-17 | 公開日 | 2015-08-19 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases. ChemMedChem, 10, 2015
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8V1T
| Herpes simplex virus 1 polymerase holoenzyme bound to DNA and acyclovir triphosphate in closed conformation | 分子名称: | ACYCLOVIR TRIPHOSPHATE, DNA polymerase, DNA polymerase processivity factor, ... | 著者 | Pan, J, Abraham, J, Coen, D.M, Shankar, S, Yang, P, Hogle, J. | 登録日 | 2023-11-21 | 公開日 | 2024-09-04 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Viral DNA polymerase structures reveal mechanisms of antiviral drug resistance. Cell, 187, 2024
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8V1R
| Herpes simplex virus 1 polymerase holoenzyme bound to DNA and DTTP in closed conformation | 分子名称: | DNA polymerase, DNA polymerase processivity factor, MAGNESIUM ION, ... | 著者 | Pan, J, Abraham, J, Coen, D.M, Shankar, S, Yang, P, Hogle, J. | 登録日 | 2023-11-21 | 公開日 | 2024-09-04 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Viral DNA polymerase structures reveal mechanisms of antiviral drug resistance. Cell, 187, 2024
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6U2G
| BRAF-MEK complex with AMP-PCP bound to BRAF | 分子名称: | Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | 著者 | Liau, N.P.D, Wendorff, T, Hymowitz, S, Sudhamsu, J. | 登録日 | 2019-08-19 | 公開日 | 2019-08-28 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.886 Å) | 主引用文献 | Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization. Nat.Struct.Mol.Biol., 27, 2020
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8V1S
| Herpes simplex virus 1 polymerase holoenzyme bound to mismatched DNA in editing conformation | 分子名称: | DNA polymerase, DNA polymerase processivity factor, MAGNESIUM ION, ... | 著者 | Pan, J, Abraham, J, Coen, D.M, Shankar, S, Yang, P, Hogle, J. | 登録日 | 2023-11-21 | 公開日 | 2024-09-04 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | 主引用文献 | Viral DNA polymerase structures reveal mechanisms of antiviral drug resistance. Cell, 187, 2024
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8V1Q
| Herpes simplex virus 1 polymerase holoenzyme bound to DNA in both open/closed conformations | 分子名称: | DNA polymerase, DNA polymerase processivity factor, MAGNESIUM ION, ... | 著者 | Pan, J, Abraham, J, Coen, D.M, Shankar, S, Yang, P, Hogle, J. | 登録日 | 2023-11-21 | 公開日 | 2024-09-04 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Viral DNA polymerase structures reveal mechanisms of antiviral drug resistance. Cell, 187, 2024
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1R49
| Human topoisomerase I (Topo70) double mutant K532R/Y723F | 分子名称: | 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(P*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', DNA topoisomerase I | 著者 | Interthal, H, Quigley, P.M, Hol, W.G, Champoux, J.J. | 登録日 | 2003-10-03 | 公開日 | 2003-12-16 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3.13 Å) | 主引用文献 | The role of lysine 532 in the catalytic mechanism of human topoisomerase I. J.Biol.Chem., 279, 2004
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5O4X
| Protein structure determination by electron diffraction using a single three-dimensional nanocrystal | 分子名称: | Lysozyme C | 著者 | Clabbers, M.T.B, van Genderen, E, Wan, W, Wiegers, E.L, Gruene, T, Abrahams, J.P. | 登録日 | 2017-05-31 | 公開日 | 2017-08-23 | 最終更新日 | 2024-01-17 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (2.11 Å) | 主引用文献 | Protein structure determination by electron diffraction using a single three-dimensional nanocrystal. Acta Crystallogr D Struct Biol, 73, 2017
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7KFW
| Structural basis for a germline-biased antibody response to SARS-CoV-2 (RBD:C1A-B3 Fab) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, heavy chain of antibody C1A-B3 Fab, ... | 著者 | Pan, J, Abraham, J, Clark, L, Clark, S. | 登録日 | 2020-10-15 | 公開日 | 2020-12-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.792 Å) | 主引用文献 | Molecular basis for a germline-biased neutralizing antibody response to SARS-CoV-2. Biorxiv, 2020
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5AEO
| Virulence-associated protein VapG from the intracellular pathogen Rhodococcus equi | 分子名称: | POTASSIUM ION, R. EQUI VAPG PROTEIN | 著者 | Okoko, T, Blagova, E.V, Whittingham, J.L, Dover, L.G, Wilkinson, A.J. | 登録日 | 2015-01-07 | 公開日 | 2015-03-25 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural Characterisation of the Virulence-Associated Protein Vapg from the Horse Pathogen Rhodococcus Equi. Vet.Microbiol., 179, 2015
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5A0A
| Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5-[(6R)-5-ethanoyl-4-methyl-2-oxidanylidene-3-[3-(trifluoromethyl)phenyl]-1,6-dihydropyrimidin-6-yl]pyridine-2-carbonitrile, ... | 著者 | vonNussbaum, F, Li, V.M.-J, Allerheiligen, S, Anlauf, S, Baerfacker, L, Bechem, M, Delbeck, M, Fitzgerald, M.F, Gerisch, M, Gielen-Haertwig, H, Haning, H, Karthaus, D, Lang, D, Lustig, K, Meibom, D, Mittendorf, J, Rosentreter, U, Schaefer, M, Schaefer, S, Schamberger, J, Telan, L.A, Tersteegen, A. | 登録日 | 2015-04-17 | 公開日 | 2015-08-19 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases. ChemMedChem, 10, 2015
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2YOG
| Plasmodium falciparum thymidylate kinase in complex with a (thio)urea- alpha-deoxythymidine inhibitor | 分子名称: | 1-[4-chloranyl-3-(trifluoromethyl)phenyl]-3-[[(2R,3S)-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3-oxidanyl-oxol an-2-yl]methyl]thiourea, THYMIDYLATE KINASE | 著者 | Huaqing, C, Carrero-Lerida, J, Silva, A.P.G, Whittingham, J.L, Brannigan, J.A, Ruiz-Perez, L.M, Read, K.D, Wilson, K.S, Gonzalez-Pacanowska, D, Gilbert, I.H. | 登録日 | 2012-10-24 | 公開日 | 2013-07-24 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Synthesis and Evaluation of Alpha-Thymidine Analogues as Novel Antimalarials. J.Med.Chem., 55, 2012
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1UZ8
| anti-Lewis X Fab fragment in complex with Lewis X | 分子名称: | IGG FAB (IGG3, KAPPA) HEAVY CHAIN 291-2G3-A, KAPPA) LIGHT CHAIN 291-2G3-A, ... | 著者 | Van Roon, A.M.M, Pannu, N.S, De Vrind, J.P.M, Hokke, C.H, Deelder, A.M, Van Der marel, G.A, Van Boom, J.H, Abrahams, J.P. | 登録日 | 2004-03-05 | 公開日 | 2004-06-29 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure of an Anti-Lewis X Fab Fragment in Complex with its Lewis X Antigen Structure, 12, 2004
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1L8W
| Crystal Structure of Lyme Disease Variable Surface Antigen VlsE of Borrelia burgdorferi | 分子名称: | VlsE1 | 著者 | Eicken, C, Sharma, V, Klabunde, T, Lawrenz, M.B, Hardham, J.M, Norris, S.J, Sacchettini, J.C. | 登録日 | 2002-03-21 | 公開日 | 2002-06-19 | 最終更新日 | 2018-03-07 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of Lyme disease variable surface antigen VlsE of Borrelia burgdorferi. J.Biol.Chem., 277, 2002
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1NLD
| FAB FRAGMENT OF A NEUTRALIZING ANTIBODY DIRECTED AGAINST AN EPITOPE OF GP41 FROM HIV-1 | 分子名称: | FAB1583 | 著者 | Davies, C, Beauchamp, J.C, Emery, D, Rawas, A, Muirhead, H. | 登録日 | 1996-07-02 | 公開日 | 1996-12-23 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structure of the Fab fragment from a neutralizing monoclonal antibody directed against an epitope of gp41 from HIV-1. Acta Crystallogr.,Sect.D, 53, 1997
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1AJZ
| STRUCTURE OF DIHYDROPTEROATE PYROPHOSPHORYLASE | 分子名称: | DIHYDROPTEROATE SYNTHASE, SULFATE ION | 著者 | Achari, A, Somers, D.O, Champness, J.N, Bryant, P.K, Rosemond, J, Stammers, D.K. | 登録日 | 1997-05-13 | 公開日 | 1998-05-13 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase. Nat.Struct.Biol., 4, 1997
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1ETA
| THE X-RAY CRYSTAL STRUCTURE REFINEMENTS OF NORMAL HUMAN TRANSTHYRETIN AND THE AMYLOIDOGENIC VAL 30-->MET VARIANT TO 1.7 ANGSTROMS RESOLUTION | 分子名称: | 3,5,3',5'-TETRAIODO-L-THYRONINE, TRANSTHYRETIN | 著者 | Braden, B.C, Steinrauf, L.K, Hamilton, J.A. | 登録日 | 1993-05-12 | 公開日 | 1995-01-26 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The x-ray crystal structure refinements of normal human transthyretin and the amyloidogenic Val-30-->Met variant to 1.7-A resolution. J.Biol.Chem., 268, 1993
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