8V1S
Herpes simplex virus 1 polymerase holoenzyme bound to mismatched DNA in editing conformation
Summary for 8V1S
| Entry DOI | 10.2210/pdb8v1s/pdb |
| EMDB information | 28663 28664 42887 42888 42889 42890 42891 |
| Descriptor | DNA polymerase, DNA polymerase processivity factor, PRIMER DNA (33-MER), ... (5 entities in total) |
| Functional Keywords | herpes simplex virus, replication, dna polymerase holoenzyme, editing conformation, transferase-dna complex, transferase/dna |
| Biological source | Human alphaherpesvirus 1 strain KOS More |
| Total number of polymer chains | 4 |
| Total formula weight | 195436.25 |
| Authors | Pan, J.,Abraham, J.,Coen, D.M.,Shankar, S.,Yang, P.,Hogle, J. (deposition date: 2023-11-21, release date: 2024-09-04) |
| Primary citation | Shankar, S.,Pan, J.,Yang, P.,Bian, Y.,Oroszlan, G.,Yu, Z.,Mukherjee, P.,Filman, D.J.,Hogle, J.,Shekhar, M.,Coen, D.M.,Abraham, J. Viral DNA polymerase structures reveal mechanisms for drug selectivity Cell(Cambridge,Mass.), 2024 Cited by DOI: 10.1016/j.cell.2024.07.048PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.26 Å) |
Structure validation
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