8V1S

Herpes simplex virus 1 polymerase holoenzyme bound to mismatched DNA in editing conformation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	DNA polymerase	polymer	1199	133614.3	1	UniProt (H9E937) In PDB	Human alphaherpesvirus 1 strain KOS
2	B	DNA polymerase processivity factor	polymer	340	36346.2	1	UniProt (H9E949) In PDB	Human alphaherpesvirus 1 strain KOS	Polymerase accessory protein
3	P	PRIMER DNA (33-MER)	polymer	33	10227.6	1		synthetic construct
4	T	TEMPLATE DNA (50-MER)	polymer	50	15223.8	1		synthetic construct
5	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)

Sequence modifications

A: 43 - 1235 (UniProt: H9E937)

PDB	External Database	Details
His 37	-	expression tag
His 38	-	expression tag
His 39	-	expression tag
His 40	-	expression tag
His 41	-	expression tag
His 42	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	195411.9
Non-Polymers*	Number of molecules	1
	Total formula weight	24.3
All*	Total formula weight	195436.3

*Water molecules are not included.