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PDB: 12 件
7QG0
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BU of 7qg0 by Molmil
Inhibitor-induced hSARM1 duplex
分子名称: NAD(+) hydrolase SARM1
著者Zalk, R, Kahzma, T, Guez-Haddad, J.
登録日2021-12-07
公開日2022-12-21
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (4.02 Å)
主引用文献A duplex structure of SARM1 octamers stabilized by a new inhibitor.
Cell.Mol.Life Sci., 80, 2022
5I6J
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BU of 5i6j by Molmil
Crystal Structure of SRGAP2 F-BARx
分子名称: SLIT-ROBO Rho GTPase-activating protein 2
著者Sporny, M, Guez-Haddad, J, Isupov, M.N, Opatowsky, Y.
登録日2016-02-16
公開日2017-03-08
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural History of Human SRGAP2 Proteins.
Mol. Biol. Evol., 34, 2017
5I7D
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Crystal Structure of srGAP2 F-BARx WT Form-2
分子名称: SLIT-ROBO Rho GTPase-activating protein 2
著者Sporny, M, Guez-Haddad, J, Isupov, M.N, Opatowsky, Y.
登録日2016-02-17
公開日2017-08-30
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (3.95 Å)
主引用文献Structural Basis for srGAP2 Membrane Interactions, and Antagonism by the Human Specific Paralog srGAP2C
To Be Published
5I6R
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Crystal Structure of srGAP2 F-BARx WT Form-1
分子名称: ACETATE ION, D-MALATE, SLIT-ROBO Rho GTPase-activating protein 2, ...
著者Sporny, M, Guez-Haddad, J, Isupov, M.N, Opatowsky, Y.
登録日2016-02-16
公開日2017-08-30
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural Basis for srGAP2 Membrane Interactions, and Antagonism by the Human Specific Paralog srGAP2C
To Be Published
7ANW
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hSARM1 NAD+ complex
分子名称: NAD(+) hydrolase SARM1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Sporny, M, Guez-Haddad, J, Khazma, T, Yaron, A, Mim, C, Isupov, M.N, Zalk, R, Dessau, M, Hons, M, Opatowsky, Y.
登録日2020-10-13
公開日2020-11-11
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (2.68 Å)
主引用文献Structural basis for SARM1 inhibition and activation under energetic stress.
Elife, 9, 2020
6ZG1
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SARM1 SAM1-2 domains
分子名称: 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, DI(HYDROXYETHYL)ETHER, ...
著者Sporny, M, Guez-Haddad, J, Khazma, T, Yaron, A, Dessau, M, Mim, C, Isupov, M.N, Zalk, R, Hons, M, Opatowsky, Y.
登録日2020-06-18
公開日2020-11-11
最終更新日2020-12-09
実験手法ELECTRON MICROSCOPY (3.77 Å)
主引用文献Structural basis for SARM1 inhibition and activation under energetic stress.
Elife, 9, 2020
6ZFX
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hSARM1 GraFix-ed
分子名称: (~{E})-4-methylnon-4-enedial, NAD(+) hydrolase SARM1
著者Sporny, M, Guez-Haddad, J, Khazma, T, Yaron, A, Dessau, M, Mim, C, Isupov, M.N, Zalk, R, Hons, M, Opatowsky, Y.
登録日2020-06-18
公開日2020-11-18
最終更新日2022-11-09
実験手法ELECTRON MICROSCOPY (2.88 Å)
主引用文献Structural basis for SARM1 inhibition and activation under energetic stress.
Elife, 9, 2020
6ZG0
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BU of 6zg0 by Molmil
SARM1 SAM1-2 domains
分子名称: 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, DI(HYDROXYETHYL)ETHER, ...
著者Sporny, M, Guez-Haddad, J, Khazma, T, Yaron, A, Dessau, M, Mim, C, Isupov, M.N, Zalk, R, Hons, M, Opatowsky, Y.
登録日2020-06-18
公開日2020-11-11
最終更新日2020-12-09
実験手法ELECTRON MICROSCOPY (7.7 Å)
主引用文献Structural basis for SARM1 inhibition and activation under energetic stress.
Elife, 9, 2020
2F4U
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Asite RNA + designer antibiotic
分子名称: (2R)-4-AMINO-N-((1R,2S,3R,4R,5S)-5-AMINO-4-[(2-AMINO-2-DEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-2-{2-[(3-AMINOPROPYL)AMINO]ETHOXY}-3-HYDROXYCYCLOHEXYL)-2-HYDROXYBUTANAMIDE, 5'-R(*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3'
著者Murray, J.B, Meroueh, S.O, Russell, R.J, Lentzen, G, Haddad, J, Mobashery, S.
登録日2005-11-24
公開日2006-05-02
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Interactions of designer antibiotics and the bacterial ribosomal aminoacyl-tRNA site
Chem.Biol., 13, 2006
2F4V
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30S ribosome + designer antibiotic
分子名称: (2R)-4-AMINO-N-{(1R,2S,3R,4R,5S)-5-AMINO-2-{2-[(2-AMINOETHYL)AMINO]ETHOXY}-4-[(2,6-DIAMINO-2,6-DIDEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-3-HYDROXYCYCLOHEXYL}-2-HYDROXYBUTANAMIDE, (2S,4S,4AR,5AS,6S,11R,11AS,12R,12AR)-7-CHLORO-4-(DIMETHYLAMINO)-6,10,11,12-TETRAHYDROXY-1,3-DIOXO-1,2,3,4,4A,5,5A,6,11,11A,12,12A-DODECAHYDROTETRACENE-2-CARBOXAMIDE, 16S ribosomal RNA, ...
著者Murray, J.B, Meroueh, S.O, Russell, R.J, Lentzen, G, Haddad, J, Mobashery, S.
登録日2005-11-24
公開日2006-07-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Interactions of designer antibiotics and the bacterial ribosome aminoacyl-tRNA site
Chem.Biol., 13, 2006
2F4S
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A-site RNA in complex with neamine
分子名称: (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside, 5'-R(P*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3'
著者Murray, J.B, Meroueh, S.O, Russell, R.J, Lentzen, G, Haddad, J, Mobashery, S.
登録日2005-11-24
公開日2006-05-02
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Interactions of designer antibiotics and the bacterial ribosomal aminoacyl-tRNA site
Chem.Biol., 13, 2006
2F4T
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BU of 2f4t by Molmil
Asite RNA + designer antibiotic
分子名称: (2R)-4-AMINO-N-{(1R,2S,3R,4R,5S)-5-AMINO-2-{2-[(2-AMINOETHYL)AMINO]ETHOXY}-4-[(2,6-DIAMINO-2,6-DIDEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-3-HYDROXYCYCLOHEXYL}-2-HYDROXYBUTANAMIDE, 5'-R(*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3', 5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3'
著者Murray, J.B, Meroueh, S.O, Russell, R.J, Lentzen, G, Haddad, J, Mobashery, S.
登録日2005-11-24
公開日2006-05-02
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Interactions of designer antibiotics and the bacterial ribosomal aminoacyl-tRNA site
Chem.Biol., 13, 2006

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