4PTE
 
 | | Structure of a carvoxamide compound (15) (N-[4-(ISOQUINOLIN-7-YL)PYRIDIN-2-YL]CYCLOPROPANECARBOXAMIDE) to GSK3b | | 分子名称: | Glycogen synthase kinase-3 beta, N-[4-(isoquinolin-7-yl)pyridin-2-yl]cyclopropanecarboxamide | | 著者 | Lewis, H.A, Sivaprakasam, P, Kish, K, Pokross, M, Dubowchik, G.M. | | 登録日 | 2014-03-10 | | 公開日 | 2015-04-08 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.033 Å) | | 主引用文献 | Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core.
Bioorg.Med.Chem.Lett., 25, 2015
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4PTG
 | | Structure of a carboxamine compound (26) (2-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}-4-METHOXYPYRIMIDINE-5-CARBOXAMIDE) to GSK3b | | 分子名称: | 2-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}-4-methoxypyrimidine-5-carboxamide, Glycogen synthase kinase-3 beta | | 著者 | Lewis, H.A, Sivaprakasam, P, Kish, K, Pokross, M, Dubowchik, G.M. | | 登録日 | 2014-03-10 | | 公開日 | 2015-04-08 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.361 Å) | | 主引用文献 | Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core.
Bioorg.Med.Chem.Lett., 25, 2015
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2QD1
 | | 2.2 Angstrom Structure of the human ferrochelatase variant E343K with substrate bound | | 分子名称: | CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, Ferrochelatase, ... | | 著者 | Medlock, A.E, Dailey, T.A, Ross, T.A, Dailey, H.A, Lanzilotta, W.N. | | 登録日 | 2007-06-20 | | 公開日 | 2007-10-30 | | 最終更新日 | 2021-10-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | A pi-Helix Switch Selective for Porphyrin Deprotonation and Product Release in Human Ferrochelatase.
J.Mol.Biol., 373, 2007
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2QD2
 | | F110A variant of human ferrochelatase with protoheme bound | | 分子名称: | BICARBONATE ION, CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, ... | | 著者 | Medlock, A.E, Dailey, T.A, Ross, T.A, Dailey, H.A, Lanzilota, W.N. | | 登録日 | 2007-06-20 | | 公開日 | 2007-10-30 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | A pi-Helix Switch Selective for Porphyrin Deprotonation and Product Release in Human Ferrochelatase.
J.Mol.Biol., 373, 2007
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2R29
 | | Neutralization of dengue virus by a serotype cross-reactive antibody elucidated by cryoelectron microscopy and x-ray crystallography | | 分子名称: | Envelope protein E, Heavy chain of Fab 1A1D-2, Light chain of Fab 1A1D-2 | | 著者 | Lok, S.M, Kostyuchenko, V.K, Nybakken, G.E, Holdaway, H.A, Battisti, A.J, Sukupolvi-petty, S, Sedlak, D, Fremont, D.H, Chipman, P.R, Roehrig, J.T, Diamond, M.S, Kuhn, R.J, Rossmann, M.G. | | 登録日 | 2007-08-24 | | 公開日 | 2007-12-25 | | 最終更新日 | 2018-01-24 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins.
Nat.Struct.Mol.Biol., 15, 2008
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5BUV
 | | X-ray structure of WbcA from Yersinia enterocolitica | | 分子名称: | 1,2-ETHANEDIOL, 6-AMINOPYRIMIDIN-2(1H)-ONE, PHOSPHATE ION, ... | | 著者 | Holden, H.M, Salinger, A.J, Brown, H.A, Thoden, J.B. | | 登録日 | 2015-06-04 | | 公開日 | 2015-08-05 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Biochemical studies on WbcA, a sugar epimerase from Yersinia enterocolitica.
Protein Sci., 24, 2015
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2QD4
 | | Wild type human ferrochelatase crystallized with MnCl2 | | 分子名称: | CHLORIDE ION, CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, ... | | 著者 | Medlock, A.E, Dailey, T.A, Ross, T.A, Dailey, H.A, Lanzilotta, W.N. | | 登録日 | 2007-06-20 | | 公開日 | 2007-10-30 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A pi-Helix Switch Selective for Porphyrin Deprotonation and Product Release in Human Ferrochelatase.
J.Mol.Biol., 373, 2007
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2QD5
 | | Structure of wild type human ferrochelatase in complex with a lead-porphyrin compound | | 分子名称: | ACETIC ACID, CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, ... | | 著者 | Meldock, A.E, Dailey, T.A, Ross, T.A, Dailey, H.A, Lanzilotta, W.N. | | 登録日 | 2007-06-20 | | 公開日 | 2007-10-30 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | A pi-Helix Switch Selective for Porphyrin Deprotonation and Product Release in Human Ferrochelatase.
J.Mol.Biol., 373, 2007
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7NBJ
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7NBM
 | | Co-crystal structure of Human Nicotinamide N-methyltransferase (NNMT) with the bisubstrate-like inhibitor (33) | | 分子名称: | (E)-3-((5,6-dihydro-2H,4H-thiazolo[5,4,3-ij]quinolin-2-ylidene)amino)-2-hydroxy-1-(4-(isoquinolin-5-yl)piperazin-1-yl)-2-methylpropan-1-one, Nicotinamide N-methyltransferase | | 著者 | Schreuder, H.A, Liesum, A. | | 登録日 | 2021-01-27 | | 公開日 | 2021-03-17 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.691 Å) | | 主引用文献 | Novel Inhibitors of Nicotinamide- N -Methyltransferase for the Treatment of Metabolic Disorders.
Molecules, 26, 2021
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7NBQ
 | | Co-crystal structure of Human Nicotinamide N-methyltransferase (NNMT) with the tricyclic inhibitor (4) | | 分子名称: | 2-methyl-1,2,6,7-tetrahydro-3H,5H-pyrido[3,2,1-ij]quinazolin-3-imine, Nicotinamide N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | | 著者 | Schreuder, H.A, Liesum, A. | | 登録日 | 2021-01-27 | | 公開日 | 2021-03-17 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.479 Å) | | 主引用文献 | Novel Inhibitors of Nicotinamide- N -Methyltransferase for the Treatment of Metabolic Disorders.
Molecules, 26, 2021
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5CR6
 | | Structure of pneumolysin at 1.98 A resolution | | 分子名称: | Pneumolysin | | 著者 | Marshall, J.E, Faraj, B.H.A, Gingras, A.R, Lonnen, R, Sheikh, M.A, El-Mezgueldi, M, Moody, P.C.E, Andrew, P.W, Wallis, R. | | 登録日 | 2015-07-22 | | 公開日 | 2015-09-16 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | The Crystal Structure of Pneumolysin at 2.0 angstrom Resolution Reveals the Molecular Packing of the Pre-pore Complex.
Sci Rep, 5, 2015
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4FUQ
 | | Crystal structure of apo MatB from Rhodopseudomonas palustris | | 分子名称: | GLYCEROL, Malonyl CoA synthetase, SULFATE ION | | 著者 | Rank, K.C, Crosby, H.A, Escalante-Semerena, J.C, Rayment, I. | | 登録日 | 2012-06-28 | | 公開日 | 2012-07-25 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.702 Å) | | 主引用文献 | Structure-Guided Expansion of the Substrate Range of Methylmalonyl Coenzyme A Synthetase (MatB) of Rhodopseudomonas palustris.
Appl.Environ.Microbiol., 78, 2012
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4FUT
 | | Crystal structure of ATP bound MatB from Rhodopseudomonas palustris | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | | 著者 | Rank, K.C, Crosby, H.A, Escalante-Semerena, J.C, Rayment, I. | | 登録日 | 2012-06-28 | | 公開日 | 2012-07-25 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure-Guided Expansion of the Substrate Range of Methylmalonyl Coenzyme A Synthetase (MatB) of Rhodopseudomonas palustris.
Appl.Environ.Microbiol., 78, 2012
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7NTH
 | | Structure of TAK1 in complex with compound 54 | | 分子名称: | 2-[[5-[[2-[bis(fluoranyl)methoxy]phenyl]methyl-[(2~{R})-1-(methylamino)-1-oxidanylidene-propan-2-yl]carbamoyl]-1~{H}-imidazol-2-yl]carbonyl]isoindole-5-carboxamide, DIMETHYL SULFOXIDE, GLYCEROL, ... | | 著者 | Veerman, J.J.N, Bruseker, Y.B, Damen, E, Heijne, E.H, van Bruggen, W, Hekking, K.F.W, Winkel, R, Hupp, C.D, Keefe, A.D, Liu, J, Thomson, H.A, Zhang, Y, Cuozzo, J.W, McRiner, A.J, Mulvihill, M.J, van Rijnsbergen, P, Zech, B, Renzetti, L.M, Babiss, L, Mueller, G. | | 登録日 | 2021-03-09 | | 公開日 | 2021-04-07 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | Discovery of 2,4-1 H -Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors.
Acs Med.Chem.Lett., 12, 2021
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7NTI
 | | Structure of TAK1 in complex with compound 22 | | 分子名称: | DIMETHYL SULFOXIDE, GLYCEROL, Mitogen-activated protein kinase 7,TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, ... | | 著者 | Veerman, J.J.N, Bruseker, Y.B, Damen, E, Heijne, E.H, van Bruggen, W, Hekking, K.F.W, Winkel, R, Hupp, C.D, Keefe, A.D, Liu, J, Thomson, H.A, Zhang, Y, Cuozzo, J.W, McRiner, A.J, Mulvihill, M.J, van Rijnsbergen, P, Zech, B, Renzetti, L.M, Babiss, L, Mueller, G. | | 登録日 | 2021-03-09 | | 公開日 | 2021-04-07 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | Discovery of 2,4-1 H -Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors.
Acs Med.Chem.Lett., 12, 2021
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4GXR
 | | Structure of ATP bound RpMatB-BxBclM chimera B3 | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CARBONATE ION, GLYCEROL, ... | | 著者 | Rank, K.C, Crosby, H.A, Escalante-Semerena, J.C, Rayment, I. | | 登録日 | 2012-09-04 | | 公開日 | 2012-10-24 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural Insights into the Substrate Specificity of the Rhodopseudomonas palustris Protein Acetyltransferase RpPat: IDENTIFICATION OF A LOOP CRITICAL FOR RECOGNITION BY RpPat.
J.Biol.Chem., 287, 2012
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7JNO
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5CR8
 | | Structure of the membrane-binding domain of pneumolysin | | 分子名称: | Pneumolysin | | 著者 | Marshall, J.E, Faraj, B.H.A, Gingras, A.R, Lonnen, R, Sheikh, M.A, El-Mezgueldi, M, Moody, P.C.E, Andrew, P.W, Wallis, R. | | 登録日 | 2015-07-22 | | 公開日 | 2015-09-16 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | The Crystal Structure of Pneumolysin at 2.0 angstrom Resolution Reveals the Molecular Packing of the Pre-pore Complex.
Sci Rep, 5, 2015
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4GXQ
 | | Crystal Structure of ATP bound RpMatB-BxBclM chimera B1 | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CARBONATE ION, MAGNESIUM ION, ... | | 著者 | Rank, K.C, Crosby, H.A, Escalante-Semerena, J.C, Rayment, I. | | 登録日 | 2012-09-04 | | 公開日 | 2012-10-24 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural Insights into the Substrate Specificity of the Rhodopseudomonas palustris Protein Acetyltransferase RpPat: IDENTIFICATION OF A LOOP CRITICAL FOR RECOGNITION BY RpPat.
J.Biol.Chem., 287, 2012
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5DU3
 | | Active form of human C1-inhibitor | | 分子名称: | Plasma protease C1 inhibitor | | 著者 | Pannu, N.S, Dijk, M, Holkers, J, Voskamp, P, Giannetti, B.M, Waterreus, W.J, van Veen, H.A. | | 登録日 | 2015-09-18 | | 公開日 | 2016-08-31 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | How Dextran Sulfate Affects C1-inhibitor Activity: A Model for Polysaccharide Potentiation.
Structure, 24, 2016
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4F4D
 | | F337R variant of human ferrochelatase | | 分子名称: | CHLORIDE ION, CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, ... | | 著者 | Lanzilotta, W.N, Medlock, A.E, Dailey, T.E, Dailey, H.A. | | 登録日 | 2012-05-10 | | 公開日 | 2012-09-12 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | F337R Variant of Human Ferrochelatase
TO BE PUBLISHED
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7LSA
 | | Ruminococcus bromii Amy12 with maltoheptaose | | 分子名称: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | 著者 | Koropatkin, N.M, Cockburn, D.W, Brown, H.A, Kibler, R.D. | | 登録日 | 2021-02-18 | | 公開日 | 2021-07-14 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Structure and substrate recognition by the Ruminococcus bromii amylosome pullulanases.
J.Struct.Biol., 213, 2021
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7LST
 | | Ruminococcus bromii Amy12-D392A with 63-a-D-glucosyl-maltotriosyl-maltotriose | | 分子名称: | ACETATE ION, CALCIUM ION, GLYCEROL, ... | | 著者 | Koropatkin, N.M, Cockburn, D.W, Brown, H.A, Kibler, R.D. | | 登録日 | 2021-02-18 | | 公開日 | 2021-07-14 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Structure and substrate recognition by the Ruminococcus bromii amylosome pullulanases.
J.Struct.Biol., 213, 2021
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7LSU
 | | Ruminococcus bromii Amy12-D392A with 63-a-D-glucosyl-maltotriose | | 分子名称: | ACETATE ION, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Koropatkin, N.M, Cockburn, D.W, Brown, H.A, Kibler, R.D. | | 登録日 | 2021-02-18 | | 公開日 | 2021-07-14 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structure and substrate recognition by the Ruminococcus bromii amylosome pullulanases.
J.Struct.Biol., 213, 2021
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