7NBM
Co-crystal structure of Human Nicotinamide N-methyltransferase (NNMT) with the bisubstrate-like inhibitor (33)
Summary for 7NBM
| Entry DOI | 10.2210/pdb7nbm/pdb |
| Related | 7BKG 7BLE 7NJB |
| Descriptor | Nicotinamide N-methyltransferase, (E)-3-((5,6-dihydro-2H,4H-thiazolo[5,4,3-ij]quinolin-2-ylidene)amino)-2-hydroxy-1-(4-(isoquinolin-5-yl)piperazin-1-yl)-2-methylpropan-1-one (3 entities in total) |
| Functional Keywords | methyl transferase, drug discovery, inhibitor complex, nicotinamide, metabolic disorders, transferase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 4 |
| Total formula weight | 127814.60 |
| Authors | Schreuder, H.A.,Liesum, A. (deposition date: 2021-01-27, release date: 2021-03-17, Last modification date: 2024-01-31) |
| Primary citation | Kannt, A.,Rajagopal, S.,Hallur, M.S.,Swamy, I.,Kristam, R.,Dhakshinamoorthy, S.,Czech, J.,Zech, G.,Schreuder, H.,Ruf, S. Novel Inhibitors of Nicotinamide- N -Methyltransferase for the Treatment of Metabolic Disorders. Molecules, 26:-, 2021 Cited by PubMed: 33668468DOI: 10.3390/molecules26040991 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.691 Å) |
Structure validation
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