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PDB: 9 results

6EOU
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BU of 6eou by Molmil
O-GlcNAc transferase TPR domain with the intellectual disability associated mutation L254F
Descriptor: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
Authors:Gundogdu, M, van Aalten, D.M.F.
Deposit date:2017-10-10
Release date:2018-05-09
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The O-GlcNAc Transferase Intellectual Disability Mutation L254F Distorts the TPR Helix.
Cell Chem Biol, 25, 2018
6Q4M
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BU of 6q4m by Molmil
Crystal structure of the O-GlcNAc transferase Asn648Tyr mutation
Descriptor: (2S,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate, PHOSPHATE ION, UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
Authors:Gundogdu, M, van Aalten, D.M.F.
Deposit date:2018-12-06
Release date:2019-12-25
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the O-GlcNAc transferase Asn648Tyr mutation
To Be Published
6IBO
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BU of 6ibo by Molmil
Catalytic deficiency of O-GlcNAc transferase leads to X-linked intellectual disability
Descriptor: (2S,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate, ALA-VAL-SER-ARG-ALA, PHOSPHATE ION, ...
Authors:Gundogdu, M, van Aalten, D.M.F.
Deposit date:2018-11-30
Release date:2019-07-24
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Catalytic deficiency of O-GlcNAc transferase leads to X-linked intellectual disability.
Proc.Natl.Acad.Sci.USA, 116, 2019
4CDR
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BU of 4cdr by Molmil
Human O-GlcNAc transferase in complex with a bisubstrate inhibitor, Goblin1
Descriptor: GOBLIN1, SULFATE ION, UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT, ...
Authors:Schimpl, M, Gundogdu, M, van Aalten, D.M.F.
Deposit date:2013-11-05
Release date:2013-12-04
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Bisubstrate Udp-Peptide Conjugates as Human O-Glcnac Transferase Inhibitors.
Biochem.J., 457, 2014
5DJS
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BU of 5djs by Molmil
Thermobaculum terrenum O-GlcNAc transferase mutant - K341M
Descriptor: Tetratricopeptide TPR_2 repeat protein, URIDINE-5'-DIPHOSPHATE
Authors:Ostrowski, A, Gundogdu, M, Ferenbach, A.T, Lebedev, A, van Aalten, D.M.F.
Deposit date:2015-09-02
Release date:2015-10-28
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Evidence for a Functional O-Linked N-Acetylglucosamine (O-GlcNAc) System in the Thermophilic Bacterium Thermobaculum terrenum.
J.Biol.Chem., 290, 2015
5DIY
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BU of 5diy by Molmil
Thermobaculum terrenum O-GlcNAc hydrolase mutant - D120N
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Hyaluronidase, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Authors:Ostrowski, A, Gundogdu, M, Ferenbach, A.T, Lebedev, A, van Aalten, D.M.F.
Deposit date:2015-09-01
Release date:2015-10-28
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Evidence for a Functional O-Linked N-Acetylglucosamine (O-GlcNAc) System in the Thermophilic Bacterium Thermobaculum terrenum.
J.Biol.Chem., 290, 2015
9C5E
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BU of 9c5e by Molmil
Covalent Complex Between Parkin Catalytic (Rcat) Domain and Ubiquitin
Descriptor: E3 ubiquitin-protein ligase parkin, Polyubiquitin-B, ZINC ION
Authors:Connelly, E.M, Rintala-Dempsey, A.C, Gundogdu, M, Freeman, E.A, Koszela, J, Aguirre, J.D, Zhu, G, Kamarainen, O, Tadayon, R, Walden, H, Shaw, G.S.
Deposit date:2024-06-06
Release date:2024-08-14
Last modified:2024-10-09
Method:SOLUTION NMR
Cite:Capturing the catalytic intermediates of parkin ubiquitination.
Proc.Natl.Acad.Sci.USA, 121, 2024
9FCJ
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BU of 9fcj by Molmil
USP1 bound to ML323 and ubiquitin conjugated to FANCD2 (ordered subset, focused refinement)
Descriptor: 5-methyl-2-(2-propan-2-ylphenyl)-~{N}-[[4-(1,2,3-triazol-1-yl)phenyl]methyl]pyrimidin-4-amine, Polyubiquitin-C, Ubiquitin carboxyl-terminal hydrolase 1, ...
Authors:Rennie, M.L, Gundogdu, M, Walden, H.
Deposit date:2024-05-15
Release date:2024-09-04
Last modified:2024-09-25
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural and Biochemical Insights into the Mechanism of Action of the Clinical USP1 Inhibitor, KSQ-4279.
J.Med.Chem., 67, 2024
9FCI
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BU of 9fci by Molmil
USP1 bound to KSQ-4279 and ubiquitin conjugated to FANCD2 (focused refinement)
Descriptor: 6-(4-cyclopropyl-6-methoxy-pyrimidin-5-yl)-1-[[4-[1-propan-2-yl-4-(trifluoromethyl)imidazol-2-yl]phenyl]methyl]pyrazolo[3,4-d]pyrimidine, Polyubiquitin-C, Ubiquitin carboxyl-terminal hydrolase 1, ...
Authors:Rennie, M.L, Gundogdu, M, Walden, H.
Deposit date:2024-05-15
Release date:2024-09-04
Last modified:2024-09-25
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural and Biochemical Insights into the Mechanism of Action of the Clinical USP1 Inhibitor, KSQ-4279.
J.Med.Chem., 67, 2024

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