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PDB: 176 件
7U1U
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Crystal structure of arabidopsis thaliana acetohydroxyacid synthase W574L mutant
分子名称: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Acetolactate synthase, chloroplastic, ...
著者Guddat, L.W, Cheng, Y.
登録日2022-02-22
公開日2022-06-01
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.22 Å)
主引用文献Structural basis of resistance to herbicides that target acetohydroxyacid synthase.
Nat Commun, 13, 2022
7TZZ
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Crystal structure of arabidopsis thaliana acetohydroxyacid synthase P197T mutant in complex with bispyribac-sodium
分子名称: 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid, 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ...
著者Guddat, L.W, Cheng, Y.
登録日2022-02-16
公開日2022-06-01
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Structural basis of resistance to herbicides that target acetohydroxyacid synthase.
Nat Commun, 13, 2022
3V9M
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Phospholipase ACII4 from Australian King Brown Snake
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ...
著者Guddat, L.W, Millers, E.K.
登録日2011-12-27
公開日2013-02-13
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.563 Å)
主引用文献Mechanistic studies on the anticoagulant activity of a phospholipase A2 from the venom of the Australian King Brown Snake (Pseudechis australis)
To be Published
8TR1
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Crystal structure of trypanosome brucei hypoxanthine guanine phosphopribosyltransferase in complex with [2S,4R]-4-Guanin-9-yl-2-(2- phosphonoethoxymethyl)-1-N-(3-phosphonopropionyl)pyrrolidine
分子名称: (3-{(2S,4R)-4-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2-phosphonoethoxy)methyl]pyrrolidin-1-yl}-3-oxopropyl)phosphonic acid, Hypoxanthine-guanine phosphoribosyltransferase
著者Guddat, L.W.
登録日2023-08-09
公開日2024-05-08
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.46 Å)
主引用文献Development of Prolinol Containing Inhibitors of Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase: Rational Structure-Based Drug Design.
J.Med.Chem., 67, 2024
8TPY
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Structure of human hypoxanthine guanine phosphoribzosyltransferase in complex with [2S,4R] 4-Guanin-9-yl-2-hydroxymethyl-1-N-(3-phosphonopropionyl)pyrrolidine
分子名称: Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION, {3-[(2S,4R)-4-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-(hydroxymethyl)pyrrolidin-1-yl]-3-oxopropyl}phosphonic acid
著者Guddat, L.W.
登録日2023-08-06
公開日2024-05-08
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Development of Prolinol Containing Inhibitors of Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase: Rational Structure-Based Drug Design.
J.Med.Chem., 67, 2024
4IJQ
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Human hypoxanthine-guanine phosphoribosyltransferase in complex with [(2-((Guanine-9H-yl)methyl)propane-1,3-diyl)bis(oxy)]bis(methylene))diphosphonic acid
分子名称: Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION, SULFATE ION, ...
著者Guddat, L.W, Keough, D.T, Hockova, D.
登録日2012-12-22
公開日2013-03-27
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.004 Å)
主引用文献Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity
J.Med.Chem., 56, 2013
7RDU
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Crystal structure of Campylobacter jejuni keto said reductoisomerase in complex with magnesium and oxidixized and reduced NADPH
分子名称: Ketol-acid reductoisomerase (NADP(+)), MAGNESIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
著者Guddat, L.W, You, L.
登録日2021-07-11
公開日2022-07-13
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.502 Å)
主引用文献Multi-faceted approach for the engineering of enzyme variants with improved properties for industrial applications
To Be Published
1ETZ
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THE THREE-DIMENSIONAL STRUCTURE OF AN ANTI-SWEETENER FAB, NC10.14, SHOWS THE EXTENT OF STRUCTURAL DIVERSITY IN ANTIGEN RECOGNITION BY IMMUNOGLOBULINS
分子名称: FAB NC10.14 - HEAVY CHAIN, FAB NC10.14 - LIGHT CHAIN, N-(P-CYANOPHENYL)-N'-DIPHENYLMETHYL-GUANIDINE-ACETIC ACID
著者Guddat, L.W, Shan, L, Broomell, C, Ramsland, P.A, Fan, Z, Anchin, J.M, Linthicum, D.S, Edmundson, A.B.
登録日2000-04-13
公開日2000-10-18
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The three-dimensional structure of a complex of a murine Fab (NC10. 14) with a potent sweetener (NC174): an illustration of structural diversity in antigen recognition by immunoglobulins.
J.Mol.Biol., 302, 2000
1UTE
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PIG PURPLE ACID PHOSPHATASE COMPLEXED WITH PHOSPHATE
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ISOPROPYL ALCOHOL, MU-OXO-DIIRON, ...
著者Guddat, L.W, Mcalpine, A, Hume, D, Hamilton, S, De Jersey, J, Martin, J.L.
登録日1999-01-18
公開日1999-10-01
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Crystal structure of mammalian purple acid phosphatase.
Structure Fold.Des., 7, 1999
8TPV
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Structure of human hypoxanthine guanine phosphoribzosyltransferase in complex with [2S,4R]-4-Guanin-9-yl-2-(2-phosphonoethoxymethyl)-1-N-(3-phosphonopropionyl)pyrrolidine
分子名称: (3-{(2S,4R)-4-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2-phosphonoethoxy)methyl]pyrrolidin-1-yl}-3-oxopropyl)phosphonic acid, Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION
著者Guddat, L.W.
登録日2023-08-05
公開日2024-05-08
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Development of Prolinol Containing Inhibitors of Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase: Rational Structure-Based Drug Design.
J.Med.Chem., 67, 2024
1ACV
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DSBA MUTANT H32S
分子名称: DSBA
著者Guddat, L.W, Martin, J.L.
登録日1997-02-10
公開日1997-10-15
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural analysis of three His32 mutants of DsbA: support for an electrostatic role of His32 in DsbA stability.
Protein Sci., 6, 1997
1AC1
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DSBA MUTANT H32L
分子名称: DSBA
著者Guddat, L.W, Martin, J.L.
登録日1997-02-10
公開日1997-10-15
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural analysis of three His32 mutants of DsbA: support for an electrostatic role of His32 in DsbA stability.
Protein Sci., 6, 1997
1CGS
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BU of 1cgs by Molmil
LOCAL AND TRANSMITTED CONFORMATIONAL CHANGES ON COMPLEXATION OF AN ANTI-SWEETENER FAB
分子名称: IGG2B-KAPPA NC6.8 FAB (HEAVY CHAIN), IGG2B-KAPPA NC6.8 FAB (LIGHT CHAIN)
著者Guddat, L.W, Shan, L, Edmundson, A.B.
登録日1993-10-06
公開日1994-05-31
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Local and transmitted conformational changes on complexation of an anti-sweetener Fab.
J.Mol.Biol., 236, 1994
1G9T
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CRYSTAL STRUCTURE OF E.COLI HPRT-GMP COMPLEX
分子名称: ANY 5'-MONOPHOSPHATE NUCLEOTIDE, GUANOSINE-5'-MONOPHOSPHATE, HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE
著者Guddat, L.W, Vos, S, Martin, J.L, keough, D.T, de Jersey, J.
登録日2000-11-28
公開日2002-08-28
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structures of free, IMP-, and GMP-bound Escherichia coli hypoxanthine phosphoribosyltransferase.
Protein Sci., 11, 2002
1G9S
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CRYSTAL STRUCTURE OF A COMPLEX BETWEEN E.COLI HPRT AND IMP
分子名称: ANY 5'-MONOPHOSPHATE NUCLEOTIDE, HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE, INOSINIC ACID
著者Guddat, L.W, Vos, S, Martin, J.L, Keough, D.T, de Jersey, J.
登録日2000-11-27
公開日2002-08-28
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structures of free, IMP-, and GMP-bound Escherichia coli hypoxanthine phosphoribosyltransferase.
Protein Sci., 11, 2002
1GRV
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Hypoxanthine Phosphoribosyltransferase from E. coli
分子名称: HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE, MAGNESIUM ION
著者Guddat, L.W, Vos, S, Martin, J.L, Keough, D.T, De Jersey, J.
登録日2001-12-17
公開日2002-12-13
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal Structures of Free, Imp-, and Gmp- Bound Escherichia Coli Hypoxanthine Phosphoribosyltransferase
Protein Sci., 11, 2002
3E9Y
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Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron
分子名称: 2-[(2E)-3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-2-(1-HYDROXYETHYLIDENE)-4-METHYL-2,3-DIHYDRO-1,3-THIAZOL-5-YL]ETHYL TRIHYDROGEN DIPHOSPHATE, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Acetolactate synthase, ...
著者Guddat, L.W, Duggleby, R.G, Wang, J.-G, Li, Z.-M.
登録日2008-08-24
公開日2009-03-31
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal structures of two novel sulfonylurea herbicides in complex with Arabidopsis thaliana acetohydroxyacid synthase.
Febs J., 276, 2009
3EA4
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Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron-ester
分子名称: 2-[(2E)-3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-2-(1-HYDROXYETHYLIDENE)-4-METHYL-2,3-DIHYDRO-1,3-THIAZOL-5-YL]ETHYL TRIHYDROGEN DIPHOSPHATE, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Acetolactate synthase, ...
著者Guddat, L.W, Wang, J.-G, Li, Z.-M.
登録日2008-08-24
公開日2009-03-31
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structures of two novel sulfonylurea herbicides in complex with Arabidopsis thaliana acetohydroxyacid synthase.
Febs J., 276, 2009
3FR7
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ketol-acid reductoisomerase (KARI) in complex with Mg2+
分子名称: MAGNESIUM ION, Putative ketol-acid reductoisomerase (Os05g0573700 protein)
著者Guddat, L.W, Leung, E.W.W.
登録日2009-01-08
公開日2009-04-14
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Conformational changes in a plant ketol-acid reductoisomerase upon Mg(2+) and NADPH binding as revealed by two crystal structures
J.Mol.Biol., 389, 2009
3GEP
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Human hypoxanthine guanine phosphoribosyltranserfase in complex with (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)guanine
分子名称: Hypoxanthine-guanine phosphoribosyltransferase, {[(1S)-2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-1-(hydroxymethyl)ethoxy]methyl}phosphonic acid
著者Guddat, L.W, Keough, D.T, Jersey, J.
登録日2009-02-25
公開日2009-08-18
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics.
J.Med.Chem., 52, 2009
3GGJ
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Human hypoxanthine-guanine phosphoribosyltransferase in complex with 9-(2-phosphonoethoxyethyl)guanine
分子名称: Hypoxanthine-guanine phosphoribosyltransferase, {2-[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethoxy]ethyl}phosphonic acid
著者Guddat, L.W, Keough, D.T, Jersey, J.
登録日2009-02-28
公開日2009-08-18
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics.
J.Med.Chem., 52, 2009
6BD9
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Saccharomyces cerevisiae acetohydroxyacid synthase
分子名称: Acetolactate synthase catalytic subunit, mitochondrial, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Guddat, L.W, Lonhienne, T.
登録日2017-10-22
公開日2017-11-08
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.982 Å)
主引用文献High resolution crystal structures of the acetohydroxyacid synthase-pyruvate complex provide new insights into its catalytic mechanism
Chemistryselect, 2017
6BD3
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Saccharomyces cerevisiae acetohydroxyacid synthase
分子名称: 2-ACETYL-THIAMINE DIPHOSPHATE, ACETATE ION, Acetolactate synthase catalytic subunit, ...
著者Guddat, L.W, Lonhienne, T.
登録日2017-10-21
公開日2017-11-08
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献High resolution crystal structures of the acetohydroxyacid synthase-pyruvate complex provide new insights into its catalytic mechanism
Chemistryselect, 2017
6BO7
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Crystal structure of Plasmodium vivax hypoxanthine guanine phosphoribosyltransferase in complex with [3R,4R]-4-guanin-9-yl-3-((S)-2-hydroxy-2-phosphonoethyl)oxy-1-N-(phosphonopropionyl)pyrrolidine
分子名称: Hypoxanthine phosphoribosyltransferase, MAGNESIUM ION, [3-[(3~{R},4~{R})-3-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-[(2~{S})-2-oxidanyl-2-phosphono-ethoxy]pyrrolidin-1-y l]-3-oxidanylidene-propyl]phosphonic acid
著者Guddat, L.W, Keough, D.T, Rejman, D.
登録日2017-11-18
公開日2017-12-13
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.856 Å)
主引用文献Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics.
ACS Chem. Biol., 13, 2018
1MCO
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THREE-DIMENSIONAL STRUCTURE OF A HUMAN IMMUNOGLOBULIN WITH A HINGE DELETION
分子名称: IGG1 MCG INTACT ANTIBODY (HEAVY CHAIN), IGG1 MCG INTACT ANTIBODY (LIGHT CHAIN), N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-L-gulopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
著者Guddat, L.W, Edmundson, A.B.
登録日1993-02-25
公開日1994-01-31
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Three-dimensional structure of a human immunoglobulin with a hinge deletion.
Proc.Natl.Acad.Sci.Usa, 90, 1993

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