3PS6
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3PRZ
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3IKG
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![BU of 3ikg by Molmil](/molmil-images/mine/3ikg) | Structure-Based Design of Novel PIN1 Inhibitors (I) | Descriptor: | (2R)-2-[(1-benzothiophen-2-ylcarbonyl)amino]-3-(3-methylphenyl)propyl phosphate, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Authors: | Parge, H, Ferre, R.A, Greasley, S, Matthews, D. | Deposit date: | 2009-08-05 | Release date: | 2009-09-22 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Structure-based design of novel human Pin1 inhibitors (I). Bioorg.Med.Chem.Lett., 19, 2009
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3GAR
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![BU of 3gar by Molmil](/molmil-images/mine/3gar) | A PH-DEPENDENT STABLIZATION OF AN ACTIVE SITE LOOP OBSERVED FROM LOW AND HIGH PH CRYSTAL STRUCTURES OF MUTANT MONOMERIC GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE | Descriptor: | GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE, PHOSPHATE ION | Authors: | Su, Y, Yamashita, M.M, Greasley, S.E, Mullen, C.A, Shim, J.H, Jennings, P.A, Benkovic, S.J, Wilson, I.A. | Deposit date: | 1998-05-13 | Release date: | 1998-08-12 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A pH-dependent stabilization of an active site loop observed from low and high pH crystal structures of mutant monomeric glycinamide ribonucleotide transformylase at 1.8 to 1.9 A. J.Mol.Biol., 281, 1998
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3IKD
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![BU of 3ikd by Molmil](/molmil-images/mine/3ikd) | Structure-Based Design of Novel PIN1 Inhibitors (I) | Descriptor: | (2R)-2-[(1-benzothiophen-2-ylcarbonyl)amino]-3-phenylpropyl phosphate, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Authors: | Matthews, D, Greasley, S, Ferre, R, Parge, H. | Deposit date: | 2009-08-05 | Release date: | 2009-09-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-based design of novel human Pin1 inhibitors (I). Bioorg.Med.Chem.Lett., 19, 2009
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3IK8
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1P4R
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![BU of 1p4r by Molmil](/molmil-images/mine/1p4r) | Crystal Structure of Human ATIC in complex with folate-based inhibitor BW1540U88UD | Descriptor: | AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, Bifunctional purine biosynthesis protein PURH, N-[(S)-(4-{[(2-AMINO-4-HYDROXYQUINAZOLIN-6-YL)(DIHYDROXY)-LAMBDA~4~-SULFANYL]AMINO}PHENYL)(HYDROXY)METHYL]-L-GLUTAMIC ACID, ... | Authors: | Cheong, C.-G, Greasley, S.E, Horton, P.A, Beardsley, G.P, Wilson, I.A. | Deposit date: | 2003-04-23 | Release date: | 2004-03-30 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates J.Biol.Chem., 279, 2004
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1PL0
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![BU of 1pl0 by Molmil](/molmil-images/mine/1pl0) | Crystal structure of human ATIC in complex with folate-based inhibitor, BW2315U89UC | Descriptor: | AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, Bifunctional purine biosynthesis protein PURH, N-(4-{[(2-AMINO-4-OXO-3,4-DIHYDROQUINAZOLIN-6-YL)AMINO]SULFONYL}BENZOYL)GLUTAMIC ACID, ... | Authors: | Cheong, C.G, Greasley, S.E, Horton, P.A, Beardsley, G.P, Wilson, I.A. | Deposit date: | 2003-06-06 | Release date: | 2004-04-27 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal Structures of Human Bifunctional Enzyme Aminoimidazole-4-carboxamide Ribonucleotide Transformylase/IMP Cyclohydrolase in Complex with Potent Sulfonyl-containing Antifolates. J.Biol.Chem., 279, 2004
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1OZ0
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![BU of 1oz0 by Molmil](/molmil-images/mine/1oz0) | CRYSTAL STRUCTURE OF THE HOMODIMERIC BIFUNCTIONAL TRANSFORMYLASE AND CYCLOHYDROLASE ENZYME AVIAN ATIC IN COMPLEX WITH A MULTISUBSTRATE ADDUCT INHIBITOR BETA-DADF. | Descriptor: | 2-[4-((2-AMINO-4-OXO-3,4-DIHYDRO-PYRIDO[3,2-D]PYRIMIDIN-6-YLMETHYL)-{3-[5-CARBAMOYL-3-(3,4- DIHYDROXY-5-PHOSPHONOOXYMETHYL-TETRAHYDRO-FURAN-2-YL)-3H-IMIDAZOL-4-YL]-ACRYLOYL}-AMINO)-BENZOYLAMINO]- PENTANEDIOIC ACID, Bifunctional purine biosynthesis protein PURH, PHOSPHATE ION, ... | Authors: | Wolan, D.W, Greasley, S.E, Wall, M.J, Benkovic, S.J, Wilson, I.A. | Deposit date: | 2003-04-07 | Release date: | 2003-09-30 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of Avian AICAR Transformylase with a Multisubstrate Adduct Inhibitor beta-DADF Identifies the Folate Binding Site. Biochemistry, 42, 2003
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1MEO
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![BU of 1meo by Molmil](/molmil-images/mine/1meo) | human glycinamide ribonucleotide Transformylase at pH 4.2 | Descriptor: | PHOSPHATE ION, Phosphoribosylglycinamide formyltransferase, SULFATE ION | Authors: | Zhang, Y, Desharnais, J, Greasley, S.E, Beardsley, G.P, Boger, D.L, Wilson, I.A. | Deposit date: | 2002-08-08 | Release date: | 2002-12-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Crystal structures of human GAR Tfase of low and high pH and with substrate beta-GAR Biochemistry, 41, 2002
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1MEN
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![BU of 1men by Molmil](/molmil-images/mine/1men) | complex structure of human GAR Tfase and substrate beta-GAR | Descriptor: | GLYCINAMIDE RIBONUCLEOTIDE, Phosphoribosylglycinamide formyltransferase | Authors: | Zhang, Y, Desharnais, J, Greasley, S.E, Beardsley, G.P, Boger, D.L, Wilson, I.A. | Deposit date: | 2002-08-08 | Release date: | 2002-12-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | Crystal structures of human GAR Tfase of low and high pH and with substrate beta-GAR Biochemistry, 41, 2002
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1MEJ
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![BU of 1mej by Molmil](/molmil-images/mine/1mej) | Human Glycinamide Ribonucleotide Transformylase domain at pH 8.5 | Descriptor: | GLYCEROL, PHOSPHATE ION, Phosphoribosylglycinamide formyltransferase | Authors: | Zhang, Y, Desharnais, J, Greasley, S.E, Beardsley, G.P, Boger, D.L, Wilson, I.A. | Deposit date: | 2002-08-08 | Release date: | 2002-12-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structures of human GAR Tfase of low and high pH and with substrate beta-GAR Biochemistry, 41, 2002
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1PKX
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![BU of 1pkx by Molmil](/molmil-images/mine/1pkx) | Crystal Structure of human ATIC in complex with XMP | Descriptor: | Bifunctional purine biosynthesis protein PURH, POTASSIUM ION, XANTHOSINE-5'-MONOPHOSPHATE | Authors: | Wolan, D.W, Cheong, C.G, Greasley, S.E, Wilson, I.A. | Deposit date: | 2003-06-06 | Release date: | 2004-02-17 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Insights into the Human and Avian IMP Cyclohydrolase Mechanism via Crystal Structures with the Bound XMP Inhibitor. Biochemistry, 43, 2004
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1D5T
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![BU of 1d5t by Molmil](/molmil-images/mine/1d5t) | GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR, ALPHA-ISOFORM | Descriptor: | GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR, SULFATE ION | Authors: | Peng, L, Zeng, K, Heine, A, Moyer, B, Greasley, S.E, Kuhn, P, Balch, W.E, Wilson, I.A. | Deposit date: | 1999-10-11 | Release date: | 2000-10-25 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.04 Å) | Cite: | A new functional domain of guanine nucleotide dissociation inhibitor (alpha-GDI) involved in Rab recycling. Traffic, 1, 2000
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