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PDB: 299 件
2Q72
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Crystal Structure Analysis of LeuT complexed with L-leucine, sodium, and imipramine
分子名称: 3-(5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE, LEUCINE, SODIUM ION, ...
著者Singh, S.K, Yamashita, A, Gouaux, E.
登録日2007-06-05
公開日2007-08-21
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.
Nature, 448, 2007
2QB4
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Crystal Structure Analysis of LeuT complexed with L-leucine, sodium and desipramine
分子名称: 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE, LEUCINE, SODIUM ION, ...
著者Singh, S.K, Yamashita, A, Gouaux, E.
登録日2007-06-15
公開日2007-08-21
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.
Nature, 448, 2007
2QEI
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Crystal structure analysis of LeuT complexed with L-alanine, sodium, and clomipramine
分子名称: 3-(3-CHLORO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE, ALANINE, SODIUM ION, ...
著者Singh, S.K, Yamashita, A, Gouaux, E.
登録日2007-06-25
公開日2007-08-21
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.
Nature, 448, 2007
3I5D
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BU of 3i5d by Molmil
Crystal structure of the ATP-gated P2X4 ion channel in the closed, apo state at 3.5 Angstroms (R3)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, P2X purinoceptor
著者Kawate, T, Michel, J.C, Gouaux, E.
登録日2009-07-05
公開日2009-08-04
最終更新日2021-10-13
実験手法X-RAY DIFFRACTION (3.46 Å)
主引用文献Crystal structure of the ATP-gated P2X(4) ion channel in the closed state.
Nature, 460, 2009
3IJ4
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Cesium sites in the crystal structure of a functional acid sensing ion channel in the desensitized state
分子名称: Amiloride-sensitive cation channel 2, neuronal, CESIUM ION, ...
著者Gonzales, E.B, Gouaux, E.
登録日2009-08-03
公開日2009-11-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Pore architecture and ion sites in acid-sensing ion channels and P2X receptors.
Nature, 460, 2009
3KG2
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AMPA subtype ionotropic glutamate receptor in complex with competitive antagonist ZK 200775
分子名称: Glutamate receptor 2, beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Sobolevsky, A.I, Rosconi, M.P, Gouaux, E.
登録日2009-10-28
公開日2009-12-08
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor.
Nature, 462, 2009
3KGC
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Isolated ligand binding domain dimer of GluA2 ionotropic glutamate receptor in complex with glutamate, LY 404187 and ZK 200775
分子名称: GLUTAMIC ACID, Glutamate receptor 2, N-[(2S)-2-(4'-cyanobiphenyl-4-yl)propyl]propane-2-sulfonamide, ...
著者Sobolevsky, A.I, Rosconi, M.P, Gouaux, E.
登録日2009-10-28
公開日2009-12-15
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor
Nature, 462, 2009
3JAE
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Structure of alpha-1 glycine receptor by single particle electron cryo-microscopy, glycine-bound state
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycine receptor subunit alphaZ1
著者Du, J, Lu, W, Wu, S.P, Cheng, Y.F, Gouaux, E.
登録日2015-06-08
公開日2015-09-09
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Glycine receptor mechanism elucidated by electron cryo-microscopy.
Nature, 526, 2015
3JAF
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Structure of alpha-1 glycine receptor by single particle electron cryo-microscopy, glycine/ivermectin-bound state
分子名称: (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycine receptor subunit alphaZ1
著者Du, J, Lu, W, Wu, S.P, Cheng, Y.F, Gouaux, E.
登録日2015-06-08
公開日2015-09-09
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.801 Å)
主引用文献Glycine receptor mechanism elucidated by electron cryo-microscopy.
Nature, 526, 2015
3JAD
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Structure of alpha-1 glycine receptor by single particle electron cryo-microscopy, strychnine-bound state
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycine receptor subunit alphaZ1, STRYCHNINE
著者Du, J, Lu, W, Wu, S.P, Cheng, Y.F, Gouaux, E.
登録日2015-06-08
公開日2015-09-09
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Glycine receptor mechanism elucidated by electron cryo-microscopy.
Nature, 526, 2015
1MS7
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BU of 1ms7 by Molmil
X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-Des-Me-AMPA at 1.97 A resolution, Crystallization in the presence of zinc acetate
分子名称: (S)-2-AMINO-3-(3-HYDROXY-ISOXAZOL-4-YL)PROPIONIC ACID, Glutamate receptor subunit 2, ZINC ION
著者Kasper, C, Lunn, M.-L, Liljefors, T, Gouaux, E, Egebjerg, J, Kastrup, J.S.
登録日2002-09-19
公開日2003-07-08
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献GluR2 ligand-binding core complexes: importance of the isoxazolol moiety and 5-substituent for the binding mode of AMPA-type agonists
FEBS Lett., 531, 2002
4U1W
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Full length GluA2-kainate-(R,R)-2b complex crystal form A
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 2, ...
著者Chen, L, Gouaux, E.
登録日2014-07-16
公開日2014-08-20
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States.
Cell, 158, 2014
4U2P
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BU of 4u2p by Molmil
Full-length AMPA subtype ionotropic glutamate receptor GluA2 in the apo state
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2
著者Duerr, K.L, Gouaux, E.
登録日2014-07-17
公開日2014-08-20
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (3.2386 Å)
主引用文献Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States.
Cell, 158, 2014
4U1X
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Full length GluA2-kainate-(R,R)-2b complex crystal form B
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, ...
著者Chen, L, Gouaux, E.
登録日2014-07-16
公開日2014-08-20
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (3.301 Å)
主引用文献Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States.
Cell, 158, 2014
4U2Q
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BU of 4u2q by Molmil
Full-length AMPA subtype ionotropic glutamate receptor GluA2 in complex with partial agonist kainate
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 2
著者Duerr, K.L, Chen, L, Gouaux, E.
登録日2014-07-17
公開日2014-08-20
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (3.5247 Å)
主引用文献Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States.
Cell, 158, 2014
4U2R
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Crystal structure of the GLUR2 ligand binding core (S1S2J, flip variant) in the apo state
分子名称: Glutamate receptor 2, SULFATE ION
著者Duerr, K.L, Chen, L, Gouaux, E.
登録日2014-07-17
公開日2014-08-20
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.4114 Å)
主引用文献Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States.
Cell, 158, 2014
4U1Z
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GluA2flip sLBD complexed with kainate and (R,R)-2b crystal form D
分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 2,Glutamate receptor 2, N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide
著者Chen, L, Gouaux, E.
登録日2014-07-16
公開日2014-08-20
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.9401 Å)
主引用文献Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States.
Cell, 158, 2014
4U21
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GluA2flip sLBD complexed with FW and (R,R)-2b crystal form E
分子名称: 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, Glutamate receptor 2,Glutamate receptor 2, N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide
著者Chen, L, Gouaux, E.
登録日2014-07-16
公開日2014-08-20
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.3908 Å)
主引用文献Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States.
Cell, 158, 2014
4U22
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GluA2flip sLBD complexed with FW and (R,R)-2b crystal form D
分子名称: 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, Glutamate receptor 2, N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide
著者Chen, L, Gouaux, E.
登録日2014-07-16
公開日2014-08-20
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.4409 Å)
主引用文献Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States.
Cell, 158, 2014
4U5D
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Crystal structure of GluA2, con-ikot-ikot snail toxin, partial agonist KA and postitive modulator (R,R)-2b complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Con-ikot-ikot, ...
著者Chen, L, Gouaux, E.
登録日2014-07-25
公開日2014-08-13
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (3.5757 Å)
主引用文献X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism.
Science, 345, 2014
4U23
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GluA2flip sLBD complexed with FW and (R,R)-2b crystal form F
分子名称: 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, Glutamate receptor 2,Glutamate receptor 2, N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide
著者Chen, L, Gouaux, E.
登録日2014-07-16
公開日2014-08-20
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.6734 Å)
主引用文献Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States.
Cell, 158, 2014
4U5G
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Crystal structure of con-ikot-ikot toxin
分子名称: Con-ikot-ikot, ZINC ION
著者Chen, L, Gouaux, E.
登録日2014-07-25
公開日2014-08-13
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.1997 Å)
主引用文献X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism.
Science, 345, 2014
4U5H
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crystal structure of con-ikot-ikot toxin
分子名称: Con-ikot-ikot
著者Chen, L, Gouaux, E.
登録日2014-07-25
公開日2014-08-13
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism.
Science, 345, 2014
4U1Y
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Full length GluA2-FW-(R,R)-2b complex
分子名称: 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2, ...
著者Chen, L, Gouaux, E.
登録日2014-07-16
公開日2014-08-20
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (3.8999 Å)
主引用文献Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States.
Cell, 158, 2014
4U1O
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GluA2flip sLBD complexed with kainate and (R,R)-2b crystal form C
分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 2, N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide
著者Chen, L, Gouaux, E.
登録日2014-07-15
公開日2014-08-20
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.8501 Å)
主引用文献Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States.
Cell, 158, 2014

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