7YIY
 
 | | Cryo-EM structure of SPT-ORMDL3 complex | | Descriptor: | N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]tetracosanamide, ORM1-like protein 3, PYRIDOXAL-5'-PHOSPHATE, ... | | Authors: | Xie, T, Liu, P, Gong, X. | | Deposit date: | 2022-07-18 | | Release date: | 2023-07-05 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Ceramide sensing by human SPT-ORMDL complex for establishing sphingolipid homeostasis.
Nat Commun, 14, 2023
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6DMB
 | | Cryo-EM structure of human Ptch1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Yan, N, Gong, X, Qian, H.W. | | Deposit date: | 2018-06-04 | | Release date: | 2018-07-11 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural basis for the recognition of Sonic Hedgehog by human Patched1.
Science, 361, 2018
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7YJM
 | | Cryo-EM structure of the monomeric atSPT-ORM1 complex | | Descriptor: | Long chain base biosynthesis protein 2a, N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]tetracosanamide, ORMDL family protein, ... | | Authors: | Xie, T, Liu, P, Gong, X. | | Deposit date: | 2022-07-20 | | Release date: | 2023-04-05 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Mechanism of sphingolipid homeostasis revealed by structural analysis of Arabidopsis SPT-ORM1 complex.
Sci Adv, 9, 2023
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7YJO
 | | Cryo-EM structure of the monomeric atSPT-ORM1 (LCB2a-deltaN5) complex | | Descriptor: | Long chain base biosynthesis protein 2a, N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]tetracosanamide, ORMDL family protein, ... | | Authors: | Xie, T, Liu, P, Gong, X. | | Deposit date: | 2022-07-20 | | Release date: | 2023-04-05 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Mechanism of sphingolipid homeostasis revealed by structural analysis of Arabidopsis SPT-ORM1 complex.
Sci Adv, 9, 2023
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7YJN
 | | Cryo-EM structure of the monomeric atSPT-ORM1 (ORM1-N17A) complex | | Descriptor: | Long chain base biosynthesis protein 1, Long chain base biosynthesis protein 2a, ORMDL family protein, ... | | Authors: | Xie, T, Liu, P, Gong, X. | | Deposit date: | 2022-07-20 | | Release date: | 2023-04-05 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Mechanism of sphingolipid homeostasis revealed by structural analysis of Arabidopsis SPT-ORM1 complex.
Sci Adv, 9, 2023
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6DMY
 | | Cryo-EM structure of human Ptch1 and ShhN complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Yan, N, Gong, X, Qian, H.W. | | Deposit date: | 2018-06-05 | | Release date: | 2018-07-11 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural basis for the recognition of Sonic Hedgehog by human Patched1.
Science, 361, 2018
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6DMO
 | | Cryo-EM structure of human Ptch1 with three mutations L282Q/T500F/P504L | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein patched homolog 1 | | Authors: | Yan, N, Gong, X, Qian, H.W. | | Deposit date: | 2018-06-05 | | Release date: | 2018-07-11 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Structural basis for the recognition of Sonic Hedgehog by human Patched1.
Science, 361, 2018
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8IAJ
 | | Cryo-EM structure of the yeast SPT-ORM2 (ORM2-S3A) complex | | Descriptor: | N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]tetracosanamide, PYRIDOXAL-5'-PHOSPHATE, Protein ORM2, ... | | Authors: | Xie, T, Gong, X. | | Deposit date: | 2023-02-08 | | Release date: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Collaborative regulation of yeast SPT-Orm2 complex by phosphorylation and ceramide.
Cell Rep, 43, 2024
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8IAK
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8IAM
 | | Cryo-EM structure of the yeast SPT-ORM2 (ORM2-S3D) complex | | Descriptor: | Chimera of Long chain base biosynthesis protein 1 and Serine palmitoyltransferase 1, N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]tetracosanamide, PYRIDOXAL-5'-PHOSPHATE, ... | | Authors: | Xie, T, Gong, X. | | Deposit date: | 2023-02-08 | | Release date: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Collaborative regulation of yeast SPT-Orm2 complex by phosphorylation and ceramide.
Cell Rep, 43, 2024
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2MKV
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7W02
 | | Cryo-EM structure of ATP-bound ABCA3 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Xie, T, Zhang, Z.K, Yue, J, Gong, X. | | Deposit date: | 2021-11-17 | | Release date: | 2022-04-20 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cryo-EM structures of the human surfactant lipid transporter ABCA3.
Sci Adv, 8, 2022
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7W01
 | | Cryo-EM structure of nucleotide-free ABCA3 | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Xie, T, Zhang, Z.K, Yue, J, Gong, X. | | Deposit date: | 2021-11-17 | | Release date: | 2022-04-27 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cryo-EM structures of the human surfactant lipid transporter ABCA3.
Sci Adv, 8, 2022
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2LQV
 | | YebF | | Descriptor: | Protein yebF | | Authors: | Prehna, G, Zhang, G, Gong, X, Duszyk, M, Okon, M, Mcintosh, L.P, Weiner, J.H, Strynadka, N.C.J. | | Deposit date: | 2012-03-16 | | Release date: | 2012-06-13 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | A Protein Export Pathway Involving Escherichia coli Porins.
Structure, 20, 2012
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2KJF
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5GYY
 | | Plant receptor complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, S-locus protein 11, S-receptor kinase SRK9 | | Authors: | Ma, R, Han, Z, Hu, Z, Lin, G, Gong, X, Zhang, H, June, N, Chai, J. | | Deposit date: | 2016-09-24 | | Release date: | 2017-09-27 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.351 Å) | | Cite: | Plant receptor complex at 2.35 Angstroms resolution
To Be Published
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4O79
 | | Crystal Structure of Ascorbate-bound Cytochrome b561, crystal soaked in 1 M L-ascorbate for 10 minutes | | Descriptor: | ASCORBIC ACID, PROTOPORPHYRIN IX CONTAINING FE, Probable transmembrane ascorbate ferrireductase 2, ... | | Authors: | Lu, P, Ma, D, Yan, C, Gong, X, Du, M, Shi, Y. | | Deposit date: | 2013-12-24 | | Release date: | 2014-02-05 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.003 Å) | | Cite: | Structure and mechanism of a eukaryotic transmembrane ascorbate-dependent oxidoreductase
Proc.Natl.Acad.Sci.USA, 111, 2014
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5DIK
 | | Crystal structure of apo-lpg0406, a carboxymuconolactone decarboxylase family protein from Legionella pneumophila | | Descriptor: | Alkyl hydroperoxide reductase AhpD | | Authors: | Chen, X, Gong, X, Zhang, N, Ge, H. | | Deposit date: | 2015-09-01 | | Release date: | 2015-10-14 | | Last modified: | 2016-01-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure of lpg0406, a carboxymuconolactone decarboxylase family protein possibly involved in antioxidative response from Legionella pneumophila
Protein Sci., 24, 2015
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5DIP
 | | Crystal structure of lpg0406 in reduced form from Legionella pneumophila | | Descriptor: | Alkyl hydroperoxide reductase AhpD, GLYCEROL, SODIUM ION | | Authors: | Chen, X, Gong, X, Zhang, N, Ge, H. | | Deposit date: | 2015-09-01 | | Release date: | 2015-10-14 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.097 Å) | | Cite: | Structure of lpg0406, a carboxymuconolactone decarboxylase family protein possibly involved in antioxidative response from Legionella pneumophila
Protein Sci., 24, 2015
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4O6Y
 | | Crystal Structure of Cytochrome b561 | | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, Probable transmembrane ascorbate ferrireductase 2, SULFATE ION | | Authors: | Lu, P, Ma, D, Yan, C, Gong, X, Du, M, Shi, Y. | | Deposit date: | 2013-12-24 | | Release date: | 2014-02-05 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structure and mechanism of a eukaryotic transmembrane ascorbate-dependent oxidoreductase
Proc.Natl.Acad.Sci.USA, 111, 2014
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4O7G
 | | Crystal Structure of Ascorbate-bound Cytochrome b561, crystal soaked in 1 M L-ascorbate for 40 minutes | | Descriptor: | ASCORBIC ACID, PROTOPORPHYRIN IX CONTAINING FE, Probable transmembrane ascorbate ferrireductase 2, ... | | Authors: | Lu, P, Ma, D, Yan, C, Gong, X, Du, M, Shi, Y. | | Deposit date: | 2013-12-24 | | Release date: | 2014-02-05 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.211 Å) | | Cite: | Structure and mechanism of a eukaryotic transmembrane ascorbate-dependent oxidoreductase
Proc.Natl.Acad.Sci.USA, 111, 2014
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5ESW
 | | Crystal structure of Apo hypoxanthine-guanine phosphoribosyltransferase from Legionella pneumophila | | Descriptor: | PHOSPHATE ION, Purine/pyrimidine phosphoribosyltransferase | | Authors: | Zhang, N, Gong, X, Lu, M, Chen, X, Qin, X, Ge, H. | | Deposit date: | 2015-11-17 | | Release date: | 2016-03-30 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structures of Apo and GMP bound hypoxanthine-guanine phosphoribosyltransferase from Legionella pneumophila and the implications in gouty arthritis
J.Struct.Biol., 194, 2016
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5ESX
 | | Crystal structure of hypoxanthine-guanine phosphoribosyltransferase complexed with GMP from Legionella pneumophila | | Descriptor: | GUANOSINE-5'-MONOPHOSPHATE, Purine/pyrimidine phosphoribosyltransferase | | Authors: | Zhang, N, Gong, X, Lu, M, Chen, X, Qin, X, Ge, H. | | Deposit date: | 2015-11-17 | | Release date: | 2016-03-30 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.71 Å) | | Cite: | Crystal structures of Apo and GMP bound hypoxanthine-guanine phosphoribosyltransferase from Legionella pneumophila and the implications in gouty arthritis
J.Struct.Biol., 194, 2016
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5XTA
 | | Crystal structure of lpg1832, a VirK family protein from Legionella pneumophila | | Descriptor: | GLYCEROL, SULFATE ION, VirK protein | | Authors: | Yin, S, Gong, X, Zhang, N, Ge, H. | | Deposit date: | 2017-06-18 | | Release date: | 2017-08-16 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of lpg1832, a VirK family protein from Legionella pneumophila, reveals a novel fold for bacterial VirK proteins
FEBS Lett., 591, 2017
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5H6X
 | | The crystal structure of RpoS fragment including a partial region 1.2 and region 2 from intracellular pathogen Legionella pneumophila | | Descriptor: | GLYCEROL, RNA polymerase sigma factor RpoS, SODIUM ION | | Authors: | Zhang, N, Chen, X, Gong, X, Ge, H. | | Deposit date: | 2016-11-15 | | Release date: | 2017-11-22 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | High-Resolution Crystal Structure of RpoS Fragment including a Partial Region 1.2 and Region 2 from the Intracellular Pathogen Legionella pneumophila
Crystals, 8, 2018
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