5OPY
 
 | | Crystal structure of anti-alphaVbeta3 integrin Fab LM609 | | Descriptor: | Heavy chain of LM609 Fab (antigen-binding fragment), Light chain of LM609 Fab (antigen-binding fragment) | | Authors: | Backovic, M, Veesler, D, Borst, A.J, James, Z.M, Zagotta, W, Ginsberg, M, Rey, F.A, DiMaio, F. | | Deposit date: | 2017-08-10 | | Release date: | 2017-10-25 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.26 Å) | | Cite: | The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha V beta 3 Integrin via Steric Hindrance.
Structure, 25, 2017
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6AVU
 | | Human alpha-V beta-3 Integrin (open conformation) in complex with the therapeutic antibody LM609 | | Descriptor: | Fab LM609 heavy chain, Fab LM609 light chain, Integrin alpha-V, ... | | Authors: | Borst, A.J, James, Z.N, Zagotta, W.N, Ginsberg, M, Rey, F.A, DiMaio, F, Backovic, M, Veesler, D. | | Deposit date: | 2017-09-04 | | Release date: | 2017-11-01 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (35 Å) | | Cite: | The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha V beta 3 Integrin via Steric Hindrance.
Structure, 25, 2017
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1Y19
 | | Structural basis for phosphatidylinositol phosphate kinase type I-gamma binding to talin at focal adhesions | | Descriptor: | Phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma, Talin 1 | | Authors: | de Pereda, J.M, Wegener, K, Santelli, E, Bate, N, Ginsberg, M.H, Critchley, D.R, Campbell, I.D, Liddington, R.C. | | Deposit date: | 2004-11-17 | | Release date: | 2005-01-04 | | Last modified: | 2016-11-30 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural bases for phosphatidylinositol phosphate kinase type I-gamma binding to talin at focal adhesions
J.Biol.Chem., 280, 2005
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3G9W
 | | Crystal Structure of Talin2 F2-F3 in Complex with the Integrin Beta1D Cytoplasmic Tail | | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Integrin beta-1D, ... | | Authors: | Anthis, N.J, Wegener, K.L, Ye, F, Kim, C, Lowe, E.D, Vakonakis, I, Bate, N, Critchley, D.R, Ginsberg, M.H, Campbell, I.D. | | Deposit date: | 2009-02-15 | | Release date: | 2009-10-20 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.165 Å) | | Cite: | The structure of an integrin/talin complex reveals the basis of inside-out signal transduction
Embo J., 28, 2009
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4X6R
 | | An Isoform-specific Myristylation Switch Targets RIIb PKA Holoenzymes to Membranes | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | | Authors: | Zhang, P, Ye, F, Bastidas, A.C, Kornev, A.P, Ginsberg, M.H, Wu, J, Taylor, S.S. | | Deposit date: | 2014-12-09 | | Release date: | 2015-07-22 | | Last modified: | 2020-06-24 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes.
Structure, 23, 2015
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3U7D
 | | Crystal structure of the KRIT1/CCM1 FERM domain in complex with the heart of glass (HEG1) cytoplasmic tail | | Descriptor: | Krev interaction trapped protein 1, Protein HEG homolog 1 | | Authors: | Gingras, A.R, Liu, J.J, Ginsberg, M.H, Assembly, Dynamics and Evolution of Cell-Cell and Cell-Matrix Adhesions (CELLMAT) | | Deposit date: | 2011-10-13 | | Release date: | 2012-09-12 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.49 Å) | | Cite: | Structural basis of the junctional anchorage of the cerebral cavernous malformations complex.
J.Cell Biol., 199, 2012
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4X6Q
 | | An Isoform-specific Myristylation Switch Targets RIIb PKA Holoenzymes to Membranes | | Descriptor: | cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase type II-beta regulatory subunit | | Authors: | Zhang, P, Ye, F, Bastidas, A.C, Kornev, A.P, Ginsberg, M.H, Taylor, S.S. | | Deposit date: | 2014-12-08 | | Release date: | 2015-07-22 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.52 Å) | | Cite: | An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes.
Structure, 23, 2015
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6AVQ
 | | The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha-V beta-3 Integrin via Steric Hindrance | | Descriptor: | Integrin alpha-V, Integrin beta-3, LM609 Fab heavy chain, ... | | Authors: | Borst, A.J, James, Z.N, Zagotta, W.N, Ginsberg, M, Rey, F.A, DiMaio, F, Backovic, M, Veesler, D. | | Deposit date: | 2017-09-04 | | Release date: | 2017-11-01 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (35 Å) | | Cite: | The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha V beta 3 Integrin via Steric Hindrance.
Structure, 25, 2017
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6AVR
 | | Human alpha-V beta-3 Integrin (intermediate conformation) in complex with the therapeutic antibody LM609 | | Descriptor: | Fab LM609 heavy chain, Fab LM609 light chain, Integrin alpha-V, ... | | Authors: | Borst, A.J, James, Z.N, Zagotta, W.N, Ginsberg, M, Rey, F.A, DiMaio, F, Backovic, M, Veesler, D. | | Deposit date: | 2017-09-04 | | Release date: | 2017-11-01 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (35 Å) | | Cite: | The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha V beta 3 Integrin via Steric Hindrance.
Structure, 25, 2017
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2K9J
 | | Integrin alphaIIb-beta3 transmembrane complex | | Descriptor: | Integrin alpha-IIb light chain, Integrin beta-3 | | Authors: | Lau, T, Kim, C, Ginsberg, M.H, Ulmer, T.S. | | Deposit date: | 2008-10-15 | | Release date: | 2009-03-24 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling
Embo J., 28, 2009
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2NA8
 | | Transmembrane Structure of the Cytokine Receptor Common Subunit beta | | Descriptor: | Cytokine receptor common subunit beta | | Authors: | Schmidt, T, Ye, F, Situ, A.J, An, W, Ginsberg, M.H, Ulmer, T.S. | | Deposit date: | 2015-12-21 | | Release date: | 2016-07-06 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | A Conserved Ectodomain-Transmembrane Domain Linker Motif Tunes the Allosteric Regulation of Cell Surface Receptors.
J.Biol.Chem., 291, 2016
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2NA9
 | | Transmembrane Structure of the P441A Mutant of the Cytokine Receptor Common Subunit beta | | Descriptor: | Cytokine receptor common subunit beta | | Authors: | Schmidt, T, Ye, F, Situ, A.J, An, W, Ginsberg, M.H, Ulmer, T.S. | | Deposit date: | 2015-12-21 | | Release date: | 2016-07-06 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | A Conserved Ectodomain-Transmembrane Domain Linker Motif Tunes the Allosteric Regulation of Cell Surface Receptors.
J.Biol.Chem., 291, 2016
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1N3K
 | | Solution structure of phosphoprotein enriched in astrocytes 15 kDa (PEA-15) | | Descriptor: | Astrocytic phosphoprotein PEA-15 | | Authors: | Hill, J.M, Vaidyanathan, H, Ramos, J.W, Ginsberg, M.H, Werner, M.H. | | Deposit date: | 2002-10-28 | | Release date: | 2003-01-14 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Recognition of ERK MAP Kinase by PEA-15 Reveals a Common Docking Site Within the Death Domain and Death Effector Domain
Embo J., 21, 2002
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1MK7
 | | CRYSTAL STRUCTURE OF AN INTEGRIN BETA3-TALIN CHIMERA | | Descriptor: | Integrin Beta3, TALIN | | Authors: | Garcia-Alvarez, B, De Pereda, J.M, Calderwood, D.A, Ulmer, T.S, Critchley, D, Campbell, I.D, Ginsberg, M.H, Liddington, R.C. | | Deposit date: | 2002-08-28 | | Release date: | 2003-01-28 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural Determinants of Integrin Recognition by Talin
Mol.Cell, 11, 2003
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1MIX
 | | Crystal structure of a FERM domain of Talin | | Descriptor: | Talin | | Authors: | Garcia-Alvarez, B, de Pereda, J.M, Calderwood, D.A, Ulmer, T.S, Critchley, D, Campbell, I.D, Ginsberg, M.H, Liddington, R.C. | | Deposit date: | 2002-08-23 | | Release date: | 2003-01-28 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structural determinants of integrin recognition by talin
Mol.Cell, 11, 2003
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1MIZ
 | | Crystal structure of an integrin beta3-talin chimera | | Descriptor: | TALIN, integrin beta3 | | Authors: | Garcia-Alvarez, B, de Pereda, J.M, Calderwood, D.A, Ulmer, T.S, Critchley, D, Campbell, I.D, Ginsberg, M.H, Liddington, R.C. | | Deposit date: | 2002-08-23 | | Release date: | 2003-01-28 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural determinants of integrin recognition by talin
Mol.Cell, 11, 2003
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1MK9
 | | CRYSTAL STRUCTURE OF AN INTEGRIN BETA3-TALIN CHIMERA | | Descriptor: | Integrin Beta3, TALIN | | Authors: | Garcia-Alvarez, B, De Pereda, J.M, Calderwood, D.A, Ulmer, T.S, Critchley, D, Campbell, I.D, Ginsberg, M.H, Liddington, R.C. | | Deposit date: | 2002-08-28 | | Release date: | 2003-01-28 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural Determinants of Integrin Recognition by Talin
Mol.Cell, 11, 2003
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2RMZ
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2RN0
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