5OPY

Crystal structure of anti-alphaVbeta3 integrin Fab LM609

Summary for 5OPY

• Entry DOI: 10.2210/pdb5opy/pdb
• Descriptor: Heavy chain of LM609 Fab (antigen-binding fragment), Light chain of LM609 Fab (antigen-binding fragment) (3 entities in total)
• Functional Keywords: antigen-binding fragment, fab, lm609, immune system
• Biological source: Mus musculus (House Mouse); More
• Total number of polymer chains: 2
• Total formula weight: 50852.08

Authors

Backovic, M.,Veesler, D.,Borst, A.J.,James, Z.M.,Zagotta, W.,Ginsberg, M.,Rey, F.A.,DiMaio, F. (deposition date: 2017-08-10, release date: 2017-10-25, Last modification date: 2024-01-17)

• Primary citation: Borst, A.J.,James, Z.M.,Zagotta, W.N.,Ginsberg, M.,Rey, F.A.,DiMaio, F.,Backovic, M.,Veesler, D.; The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha V beta 3 Integrin via Steric Hindrance.; Structure, 25:1732-1739.e5, 2017; PubMed: 29033288; DOI: 10.1016/j.str.2017.09.007

Experimental method

X-RAY DIFFRACTION (2.26 Å)