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PDB: 71 件
1QFU
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BU of 1qfu by Molmil
INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH A NEUTRALIZING ANTIBODY
分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTEIN (HEMAGGLUTININ (HA1 CHAIN)), ...
著者Fleury, D, Gigant, B, Bizebard, T, Daniels, R.S, Skehel, J.J, Knossow, M.
登録日1999-04-14
公開日1999-04-16
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献A complex of influenza hemagglutinin with a neutralizing antibody that binds outside the virus receptor binding site.
Nat.Struct.Biol., 6, 1999
8CGZ
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BU of 8cgz by Molmil
tubulin-AB8939 complex
分子名称: 1-[4-[2-[[5-(ethoxymethyl)-2-methyl-phenyl]amino]-1,3-oxazol-5-yl]phenyl]imidazolidin-2-one, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Varela, P.F, Gigant, B.
登録日2023-02-06
公開日2024-08-14
実験手法X-RAY DIFFRACTION (2.527 Å)
主引用文献Development of AB8939, a Novel Colchicine-like Microtubule Synthetic Destabilizer with the Ability to Overcome Multidrug Resistance
TO BE PUBLISHED
6TH4
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BU of 6th4 by Molmil
Tubulin-inhibitor complex
分子名称: 1,2,3,9-tetramethoxy-6-methylidene-5~{H}-cyclohepta[a]naphthalen-8-one, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Varela, P.F, Gigant, B.
登録日2019-11-18
公開日2021-12-01
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.121 Å)
主引用文献B-nor-methylene Colchicinoid PT-100 Selectively Induces Apoptosis in Multidrug-Resistant Human Cancer Cells via an Intrinsic Pathway in a Caspase-Independent Manner
Acs Omega, 7, 2022
4Y05
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BU of 4y05 by Molmil
KIF2C short Loop2 construct
分子名称: ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF2C, MAGNESIUM ION, ...
著者Wang, W, Knossow, M, Gigant, B.
登録日2015-02-05
公開日2015-06-17
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献New Insights into the Coupling between Microtubule Depolymerization and ATP Hydrolysis by Kinesin-13 Protein Kif2C.
J.Biol.Chem., 290, 2015
7Q1E
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BU of 7q1e by Molmil
CPAP:TUBULIN:IIH5 ALPHAREP COMPLEX
分子名称: Centromere protein J, GLYCEROL, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Campanacci, V, Gigant, b.
登録日2021-10-19
公開日2022-04-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural convergence for tubulin binding of CPAP and vinca domain microtubule inhibitors.
Proc.Natl.Acad.Sci.USA, 119, 2022
7Q1F
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BU of 7q1f by Molmil
CPAP:TUBULIN:IE5 ALPHAREP COMPLEX
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CITRATE ANION, Centromere protein J, ...
著者Campanacci, V, Gigant, b.
登録日2021-10-19
公開日2022-04-20
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.347 Å)
主引用文献Structural convergence for tubulin binding of CPAP and vinca domain microtubule inhibitors.
Proc.Natl.Acad.Sci.USA, 119, 2022
4DRX
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BU of 4drx by Molmil
GTP-Tubulin in complex with a DARPIN
分子名称: Designed ankyrin repeat protein (DARPIN) D1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Pecqueur, L, Gigant, B, Knossow, M.
登録日2012-02-17
公開日2012-07-11
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献A designed ankyrin repeat protein selected to bind to tubulin caps the microtubule plus end.
Proc.Natl.Acad.Sci.USA, 109, 2012
1KEN
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BU of 1ken by Molmil
INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH AN ANTIBODY THAT PREVENTS THE HEMAGGLUTININ LOW PH FUSOGENIC TRANSITION
分子名称: alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, hemagglutinin HA1, hemagglutinin HA2, ...
著者Barbey-Martin, C, Gigant, B, Bizebard, T, Calder, L.J, Wharto, S.A, Skehel, J.J, Knossow, M.
登録日2001-11-16
公開日2002-04-24
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献An Antibody that Prevents the Hemagglutinin Low pH Fusogenic Transition
VIROLOGY, 294, 2002
4LNU
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BU of 4lnu by Molmil
Nucleotide-free kinesin motor domain in complex with tubulin and a DARPin
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Designed ankyrin repeat protein (DARPIN) D1, GLYCEROL, ...
著者Cao, L, Gigant, B, Knossow, M.
登録日2013-07-12
公開日2014-12-03
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献The structure of apo-kinesin bound to tubulin links the nucleotide cycle to movement
Nat Commun, 5, 2014
1KNO
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BU of 1kno by Molmil
CRYSTAL STRUCTURE OF THE COMPLEX OF A CATALYTIC ANTIBODY FAB WITH A TRANSITION STATE ANALOG: STRUCTURAL SIMILARITIES IN ESTERASE-LIKE ABZYMES
分子名称: IGG2A FAB FRAGMENT CNJ206, METHYL-PHOSPHONIC ACID MONO-(4-NITRO-PHENYL) ESTER, ZINC ION
著者Charbonnier, J.-B, Gigant, B, Knossow, M.
登録日1995-09-11
公開日1996-01-29
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Crystal structure of the complex of a catalytic antibody Fab fragment with a transition state analog: structural similarities in esterase-like catalytic antibodies.
Proc.Natl.Acad.Sci.USA, 92, 1995
1SA1
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BU of 1sa1 by Molmil
Tubulin-podophyllotoxin: stathmin-like domain complex
分子名称: 9-HYDROXY-5-(3,4,5-TRIMETHOXYPHENYL)-5,8,8A,9-TETRAHYDROFURO[3',4':6,7]NAPHTHO[2,3-D][1,3]DIOXOL-6(5AH)-ONE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Ravelli, R.B, Gigant, B, Curmi, P.A, Jourdain, I, Lachkar, S, Sobel, A, Knossow, M.
登録日2004-02-06
公開日2004-03-23
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (4.2 Å)
主引用文献Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain.
Nature, 428, 2004
1SA0
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BU of 1sa0 by Molmil
TUBULIN-COLCHICINE: STATHMIN-LIKE DOMAIN COMPLEX
分子名称: 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Ravelli, R.B, Gigant, B, Curmi, P.A, Jourdain, I, Lachkar, S, Sobel, A, Knossow, M.
登録日2004-02-06
公開日2004-03-23
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3.58 Å)
主引用文献Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain.
Nature, 428, 2004
5LT0
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BU of 5lt0 by Molmil
nucleotide-free kinesin-1 motor domain, P212121 crystal form
分子名称: ACETATE ION, Kinesin-like protein, STRONTIUM ION, ...
著者Cao, L, Gigant, B.
登録日2016-09-06
公開日2017-03-01
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The structural switch of nucleotide-free kinesin.
Sci Rep, 7, 2017
5LT2
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BU of 5lt2 by Molmil
nucleotide-free kinesin-1 motor domain, P1 crystal form
分子名称: Kinesin-like protein, SULFATE ION
著者Cao, L, Gigant, B.
登録日2016-09-06
公開日2017-03-01
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The structural switch of nucleotide-free kinesin.
Sci Rep, 7, 2017
3E22
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BU of 3e22 by Molmil
Tubulin-colchicine-soblidotin: Stathmin-like domain complex
分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Cormier, A, Marchand, M, Ravelli, R.B, Knossow, M, Gigant, B.
登録日2008-08-05
公開日2008-10-21
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Structural insight into the inhibition of tubulin by vinca domain peptide ligands
Embo Rep., 9, 2008
3DU7
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BU of 3du7 by Molmil
Tubulin-colchicine-phomopsin A: Stathmin-like domain complex
分子名称: 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Cormier, A, Marchand, M, Ravelli, R.B, Knossow, M, Gigant, B.
登録日2008-07-17
公開日2008-10-21
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (4.1 Å)
主引用文献Structural insight into the inhibition of tubulin by vinca domain peptide ligands
Embo Rep., 9, 2008
3UT5
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BU of 3ut5 by Molmil
Tubulin-Colchicine-Ustiloxin: Stathmin-like domain complex
分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Ranaivoson, F.M, Gigant, B, Knossow, M.
登録日2011-11-25
公開日2012-08-01
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.73 Å)
主引用文献Structural plasticity of tubulin assembly probed by vinca-domain ligands.
Acta Crystallogr.,Sect.D, 68, 2012
7A40
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BU of 7a40 by Molmil
Nucleotide-free OSM-3 kinesin motor domain
分子名称: GLYCEROL, Osmotic avoidance abnormal protein 3, SULFATE ION
著者Varela, F.P, Menetrey, J, Gigant, B.
登録日2020-08-19
公開日2021-02-03
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.297 Å)
主引用文献Structural snapshots of the kinesin-2 OSM-3 along its nucleotide cycle: implications for the ATP hydrolysis mechanism.
Febs Open Bio, 11, 2021
7A5E
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BU of 7a5e by Molmil
OSM-3 kinesin motor domain complexed with Mg.AMPPNP
分子名称: GLYCEROL, MAGNESIUM ION, Osmotic avoidance abnormal protein 3, ...
著者Varela, F.P, Menetrey, J, Gigant, B.
登録日2020-08-21
公開日2021-02-03
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.904 Å)
主引用文献Structural snapshots of the kinesin-2 OSM-3 along its nucleotide cycle: implications for the ATP hydrolysis mechanism.
Febs Open Bio, 11, 2021
7A3Z
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BU of 7a3z by Molmil
OSM-3 kinesin motor domain complexed with Mg.ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Osmotic avoidance abnormal protein 3
著者Varela, F.P, Menetrey, J, Gigant, B.
登録日2020-08-19
公開日2021-02-03
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.095 Å)
主引用文献Structural snapshots of the kinesin-2 OSM-3 along its nucleotide cycle: implications for the ATP hydrolysis mechanism.
Febs Open Bio, 11, 2021
4P40
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BU of 4p40 by Molmil
Chlamydia pneumoniae CopN
分子名称: CHLORIDE ION, CopN, DIMETHYLAMINE, ...
著者Nawrotek, A, Guimaraes, B.G, Knossow, M, Gigant, B.
登録日2014-03-10
公開日2014-07-30
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Biochemical and Structural Insights into Microtubule Perturbation by CopN from Chlamydia pneumoniae.
J.Biol.Chem., 289, 2014
4P3Z
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BU of 4p3z by Molmil
Chlamydia pneumoniae CopN (D29 construct)
分子名称: CopN, GLYCEROL, SULFATE ION
著者Nawrotek, A, Guimaraes, B.G, Knossow, M, Gigant, B.
登録日2014-03-10
公開日2014-07-30
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Biochemical and Structural Insights into Microtubule Perturbation by CopN from Chlamydia pneumoniae.
J.Biol.Chem., 289, 2014
5EYL
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BU of 5eyl by Molmil
TUBULIN-BINDING DARPIN
分子名称: DESIGNED ANKYRIN REPEAT PROTEIN (DARPIN), GLYCEROL, PHOSPHATE ION
著者Ahmad, S, Kossow, M, Gigant, B.
登録日2015-11-25
公開日2016-07-20
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Destabilizing an interacting motif strengthens the association of a designed ankyrin repeat protein with tubulin.
Sci Rep, 6, 2016
5EYP
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BU of 5eyp by Molmil
TUBULIN-DARPIN COMPLEX
分子名称: DESIGNED ANKYRIN REPEAT PROTEIN (DARPIN), GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ...
著者Ahmad, S, Knossow, M, Gigant, B.
登録日2015-11-25
公開日2016-07-20
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Destabilizing an interacting motif strengthens the association of a designed ankyrin repeat protein with tubulin.
Sci Rep, 6, 2016
1SQK
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CRYSTAL STRUCTURE OF CIBOULOT IN COMPLEX WITH SKELETAL ACTIN
分子名称: ACTIN, ALPHA SKELETAL MUSCLE, ADENOSINE-5'-DIPHOSPHATE, ...
著者Hertzog, M, Van Heijenoort, C, Didry, D, Gaudier, M, Gigant, B, Coutant, J, Didelot, G, Preat, T, Knossow, M, Guittet, E, Carlier, M.F.
登録日2004-03-19
公開日2004-06-15
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The beta-Thymosin/WH2 Domain; Structural Basis for the Switch from Inhibition to Promotion of Actin Assembly
Cell(Cambridge,Mass.), 117, 2004

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