1E14
 
 | | PHOTOSYNTHETIC REACTION CENTER MUTANT WITH PHE M197 REPLACED WITH ARG (CHAIN M, FM197R) AND GLY M203 REPLACED WITH ASP (CHAIN M, GM203D) | | 分子名称: | BACTERIOCHLOROPHYLL A, BACTERIOPHEOPHYTIN A, CARDIOLIPIN, ... | | 著者 | Fyfe, P.K, Ridge, J.P, McAuley, K.E, Cogdell, R.J, Isaacs, N.W, Jones, M.R. | | 登録日 | 2000-04-18 | | 公開日 | 2000-06-02 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural Consequences of the Replacement of Glycine M203 with Aspartic Acid in the Reaction Center from Rhodobacter Sphaeroides.
Biochemistry, 39, 2000
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2JJ0
 | | PHOTOSYNTHETIC REACTION CENTER MUTANT WITH ALA M248 REPLACED WITH TRP (CHAIN M, AM248W) | | 分子名称: | BACTERIOCHLOROPHYLL A, BACTERIOPHEOPHYTIN A, CARDIOLIPIN, ... | | 著者 | Fyfe, P.K, Potter, J.A, Cheng, J, Williams, C.M, Watson, A.J, Jones, M.R. | | 登録日 | 2007-07-03 | | 公開日 | 2007-09-04 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural Responses to Cavity-Creating Mutations in an Integral Membrane Protein.
Biochemistry, 46, 2007
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1UMX
 | | PHOTOSYNTHETIC REACTION CENTER MUTANT WITH ARG M267 REPLACED WITH LEU (CHAIN M, R267L) | | 分子名称: | BACTERIOCHLOROPHYLL A, BACTERIOPHEOPHYTIN B, FE (III) ION, ... | | 著者 | Fyfe, P.K, Isaacs, N.W, Cogdell, R.J, Jones, M.R. | | 登録日 | 2003-09-02 | | 公開日 | 2004-06-29 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Disruption of a specific molecular interaction with a bound lipid affects the thermal stability of the purple bacterial reaction centre.
Biochim.Biophys.Acta, 1608, 2004
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2JIY
 | | PHOTOSYNTHETIC REACTION CENTER MUTANT WITH ALA M149 REPLACED WITH TRP (CHAIN M, AM149W) | | 分子名称: | BACTERIOCHLOROPHYLL A, BACTERIOPHEOPHYTIN A, CARDIOLIPIN, ... | | 著者 | Fyfe, P.K, Potter, J.A, Cheng, J, Williams, C.M, Watson, A.J, Jones, M.R. | | 登録日 | 2007-07-03 | | 公開日 | 2007-09-04 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural Responses to Cavity-Creating Mutations in an Integral Membrane Protein.
Biochemistry, 46, 2007
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5LSE
 | | PHOTOSYNTHETIC REACTION CENTER MUTANT WITH Glu L212 replaced with Ala (CHAIN L, EL212W), Asp L213 replaced with ALA (Chain L, DL213A) AND LEU M215 REPLACED WITH ALA (CHAIN M, LM215A) | | 分子名称: | BACTERIOCHLOROPHYLL A, BACTERIOPHEOPHYTIN A, CARDIOLIPIN, ... | | 著者 | Fyfe, P.K, Jones, M.R. | | 登録日 | 2016-08-25 | | 公開日 | 2016-11-09 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | On the mechanism of ubiquinone mediated photocurrent generation by a reaction center based photocathode.
Biochim.Biophys.Acta, 1857, 2016
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5LRI
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7ZMZ
 | | Engineered Interleukin 2 bound to CD25 receptor | | 分子名称: | Interleukin-2, Interleukin-2 receptor subunit alpha | | 著者 | Fyfe, P.K, Moraga, I, Gaggero, S, Mitra, S. | | 登録日 | 2022-04-20 | | 公開日 | 2022-12-14 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein.
Sci Immunol, 7, 2022
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2WTA
 | | Acinetobacter baumanii nicotinamidase pyrazinamidease | | 分子名称: | CHLORIDE ION, GLYCEROL, NICOTINAMIDASE, ... | | 著者 | Fyfe, P.K, Rao, V.A, Zemla, A, Cameron, S, Hunter, W.N. | | 登録日 | 2009-09-15 | | 公開日 | 2009-11-10 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Specificity and Mechanism of Acinetobacter Baumanii Nicotinamidase: Implications for Activation of the Front-Line Tuberculosis Drug Pyrazinamide.
Angew.Chem.Int.Ed.Engl., 48, 2009
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2WT9
 | | Acinetobacter baumanii nicotinamidase pyrazinamidease | | 分子名称: | GLYCEROL, NICOTINAMIDASE, NICOTINIC ACID, ... | | 著者 | Fyfe, P.K, Rao, V.A, Zemla, A, Cameron, S, Hunter, W.N. | | 登録日 | 2009-09-15 | | 公開日 | 2009-11-10 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Specificity and Mechanism of Acinetobacter Baumanii Nicotinamidase: Implications for Activation of the Front-Line Tuberculosis Drug Pyrazinamide.
Angew.Chem.Int.Ed.Engl., 48, 2009
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2WYO
 | | Trypanosoma brucei glutathione synthetase | | 分子名称: | GLUTATHIONE, GLUTATHIONE SYNTHETASE, SULFATE ION | | 著者 | Fyfe, P.K, Alphey, M.S, Hunter, W.N. | | 登録日 | 2009-11-17 | | 公開日 | 2010-01-19 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | | 主引用文献 | Structure of Trypanosoma Brucei Glutathione Synthetase; Domain and Loop Alterations in the Catalytic Cycle of a Highly Conserved Enzyme.
Mol.Biochem.Parasitol., 170, 2010
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2VOB
 | | TRYPANOTHIONE SYNTHETASE | | 分子名称: | CHLORIDE ION, TRYPANOTHIONE SYNTHETASE | | 著者 | Fyfe, P.K, Oza, S.L, Fairlamb, A.H, Hunter, W.N. | | 登録日 | 2008-02-13 | | 公開日 | 2008-05-06 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Leishmania Trypanothione Synthetase-Amidase Structure Reveals a Basis for Regulation of Conflicting Synthetic and Hydrolytic Activities.
J.Biol.Chem., 283, 2008
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2VPS
 | | Structure Of The Bifunctional Leishmania Major Trypanothione Synthetase-Amidase | | 分子名称: | BROMIDE ION, CHLORIDE ION, TRYPANOTHIONE SYNTHETASE | | 著者 | Fyfe, P.K, Oza, S.L, Fairlamb, A.H, Hunter, W.N. | | 登録日 | 2008-03-04 | | 公開日 | 2008-05-06 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Leishmania Trypanothione Synthetase-Amidase Structure Reveals a Basis for Regulation of Conflicting Synthetic and Hydrolytic Activities.
J.Biol.Chem., 283, 2008
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2VPM
 | | Trypanothione synthetase | | 分子名称: | BROMIDE ION, CHLORIDE ION, TRYPANOTHIONE SYNTHETASE | | 著者 | Fyfe, P.K, Oza, S.L, Fairlamb, A.H, Hunter, W.N. | | 登録日 | 2008-03-03 | | 公開日 | 2008-05-06 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Leishmania Trypanothione Synthetase-Amidase Structure Reveals a Basis for Regulation of Conflicting Synthetic and Hydrolytic Activities.
J.Biol.Chem., 283, 2008
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2X75
 | | Staphylococcus aureus adenylosuccinate lyase | | 分子名称: | ADENOSINE MONOPHOSPHATE, ADENYLOSUCCINATE LYASE, CHLORIDE ION, ... | | 著者 | Fyfe, P.K, Dawson, A, Hutchison, M.T, Cameron, S, Hunter, W.N. | | 登録日 | 2010-02-23 | | 公開日 | 2010-03-09 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure of Staphylococcus Aureus Adenylosuccinate Lyase (Purb) and Assessment of its Potential as a Target for Structure-Based Inhibitor Discovery.
Acta Crystallogr.,Sect.D, 66, 2010
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4AGS
 | | Leishmania TDR1 - a unique trimeric glutathione transferase | | 分子名称: | 1,2-ETHANEDIOL, GLUTATHIONE, THIOL-DEPENDENT REDUCTASE 1 | | 著者 | Fyfe, P.K, Westrop, G.D, Silva, A.M, Coombs, G.H, Hunter, W.N. | | 登録日 | 2012-01-31 | | 公開日 | 2012-07-04 | | 最終更新日 | 2012-08-01 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Leishmania Tdr1 Structure, a Unique Trimeric Glutathione Transferase Capable of Deglutathionylation and Antimonial Prodrug Activation.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4AIR
 | | Leishmania major cysteine synthase | | 分子名称: | CHLORIDE ION, Cysteine synthase, FGA-FGA-FGA-FGA, ... | | 著者 | Fyfe, P.K, Westrop, G.D, Coombs, G.H, Hunter, W.N. | | 登録日 | 2012-02-13 | | 公開日 | 2012-02-29 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structure of Leishmania Major Cysteine Synthase.
Acta Crystallogr.,Sect.F, 68, 2012
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1E6D
 | | PHOTOSYNTHETIC REACTION CENTER MUTANT WITH TRP M115 REPLACED WITH PHE (CHAIN M, WM115F) PHE M197 REPLACED WITH ARG (CHAIN M, FM197R) | | 分子名称: | BACTERIOCHLOROPHYLL A, BACTERIOPHEOPHYTIN A, FE (III) ION, ... | | 著者 | Ridge, J.P, Fyfe, P.K, McAuley, K.E, Van Brederode, M.E, Robert, B, Van Grondelle, R, Isaacs, N.W, Cogdell, R.J, Jones, M.R. | | 登録日 | 2000-08-11 | | 公開日 | 2000-10-30 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | An Examination of How Structural Changes Can Affect the Rate of Electron Transfer in a Mutated Bacterial Photoreaction Centre
Biochem.J., 351, 2000
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5OPZ
 | | Crystal structure of Serratia marcescens L-Ala D-Glu endopeptidase ChiX | | 分子名称: | CHLORIDE ION, ChiX, ZINC ION | | 著者 | Owen, R.A, Fyfe, P.K, Lodge, A, Biboy, J, Vollmer, W, Hunter, W.N, Sargent, F. | | 登録日 | 2017-08-10 | | 公開日 | 2018-01-17 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.34 Å) | | 主引用文献 | Structure and activity of ChiX: a peptidoglycan hydrolase required for chitinase secretion by Serratia marcescens.
Biochem. J., 475, 2018
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5OQ1
 | | Crystal structure of Serratia marcescens ChiX (used as MR model for superior PDB 5OPZ) | | 分子名称: | CHLORIDE ION, ChiX, ZINC ION | | 著者 | Owen, R.A, Fyfe, P.K, Lodge, A, Biboy, J, Vollmer, W, Hunter, W.N, Sargent, F. | | 登録日 | 2017-08-10 | | 公開日 | 2018-01-17 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.34 Å) | | 主引用文献 | Structure and activity of ChiX: a peptidoglycan hydrolase required for chitinase secretion by Serratia marcescens.
Biochem. J., 475, 2018
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1QOV
 | | PHOTOSYNTHETIC REACTION CENTER MUTANT WITH ALA M260 REPLACED WITH TRP (CHAIN M, A260W) | | 分子名称: | BACTERIOCHLOROPHYLL A, BACTERIOPHEOPHYTIN A, CARDIOLIPIN, ... | | 著者 | McAuley, K.E, Fyfe, P.K, Ridge, J.P, Isaacs, N.W, Cogdell, R.J, Jones, M.R. | | 登録日 | 1999-11-17 | | 公開日 | 1999-12-13 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural Details of an Interaction between Cardiolipin and an Integral Membrane Protein
Proc.Natl.Acad.Sci.USA, 96, 1999
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2BOZ
 | | Photosynthetic Reaction Center Mutant With Gly M203 Replaced With Leu | | 分子名称: | BACTERIOCHLOROPHYLL A, BACTERIOPHEOPHYTIN A, DECANE, ... | | 著者 | Potter, J.P, Fyfe, P.K, Jones, M.R. | | 登録日 | 2005-04-15 | | 公開日 | 2005-05-20 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Strong Effects of an Individual Water Molecule on the Rate of Light-Driven Charge Separation in the Rhodobacter Sphaeroides Reaction Center.
J.Biol.Chem., 280, 2005
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5AJ8
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1MPS
 | | PHOTOSYNTHETIC REACTION CENTER MUTANT WITH PHE M 197 REPLACED WITH ARG AND TYR M 177 REPLACED WITH PHE (CHAIN M, Y177F, F197R) | | 分子名称: | BACTERIOCHLOROPHYLL A, BACTERIOPHEOPHYTIN A, FE (II) ION, ... | | 著者 | Mcauley-Hecht, K.E, Fyfe, P.K, Ridge, J.P, Prince, S, Hunter, C.N, Isaacs, N.W, Cogdell, R.J, Jones, M.R. | | 登録日 | 1998-03-09 | | 公開日 | 1998-10-14 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Structural studies of wild-type and mutant reaction centers from an antenna-deficient strain of Rhodobacter sphaeroides: monitoring the optical properties of the complex from bacterial cell to crystal.
Biochemistry, 37, 1998
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2C7V
 | | Structure of Trypanosoma brucei pteridine reductase (PTR1) in ternary complex with cofactor and the antifolate methotrexate | | 分子名称: | ACETATE ION, METHOTREXATE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Dawson, A, Gibellini, F, Sienkiewicz, N, Fyfe, P.K, McLuskey, K, Fairlamb, A.H, Hunter, W.N. | | 登録日 | 2005-11-29 | | 公開日 | 2006-09-19 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure and Reactivity of Trypanosoma Brucei Pteridine Reductase: Inhibition by the Archetypal Antifolate Methotrexate
Mol.Microbiol., 61, 2006
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2JLA
 | | Crystal structure of E.coli MenD, 2-succinyl-5-enolpyruvyl-6-hydroxy- 3-cyclohexadiene-1-carboxylate synthase - SeMet protein | | 分子名称: | 2-SUCCINYL-5-ENOLPYRUVYL-6-HYDROXY-3-CYCLOHEXENE -1-CARBOXYLATE SYNTHASE, CHLORIDE ION, MANGANESE (II) ION, ... | | 著者 | Dawson, A, Fyfe, P.K, Hunter, W.N. | | 登録日 | 2008-09-05 | | 公開日 | 2008-10-21 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | | 主引用文献 | Specificity and Reactivity in Menaquinone Biosynthesis: The Structure of Escherichia Coli Mend (2-Succinyl-5-Enolpyruvyl-6-Hydroxy-3-Cyclohexadiene-1-Carboxylate Synthase).
J.Mol.Biol., 384, 2008
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