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PDB: 161 件

3EA5
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Kap95p Binding Induces the Switch Loops of RanGDP to adopt the GTP-bound Conformation: Implications for Nuclear Import Complex Assembly Dynamics
分子名称: GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, Importin subunit beta-1, ...
著者Forwood, J.K, Lonhienne, J.K, Guncar, G, Stewart, M, Marfori, M, Kobe, B.
登録日2008-08-24
公開日2008-10-21
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Kap95p binding induces the switch loops of RanGDP to adopt the GTP-bound conformation: implications for nuclear import complex assembly dynamics.
J.Mol.Biol., 383, 2008
2V1O
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BU of 2v1o by Molmil
Crystal structure of N-terminal domain of acyl-CoA thioesterase 7
分子名称: COENZYME A, CYTOSOLIC ACYL COENZYME A THIOESTER HYDROLASE
著者Forwood, J.K, Thakur, A.S, Guncar, G, Marfori, M, Mouradov, D, Meng, W.N, Robinson, J, Huber, T, Kellie, S, Martin, J.L, Hume, D.A, Kobe, B.
登録日2007-05-28
公開日2007-06-26
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Structural Basis for Recruitment of Tandem Hotdog Domains in Acyl-Coa Thioesterase 7 and its Role in Inflammation.
Proc.Natl.Acad.Sci.USA, 104, 2007
3ND2
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BU of 3nd2 by Molmil
Structure of Yeast Importin-beta (Kap95p)
分子名称: Importin subunit beta-1
著者Forwood, J.K, Kobe, B.
登録日2010-06-06
公開日2010-07-07
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Quantitative Structural Analysis of Importin-beta Flexibility: Paradigm for Solenoid Protein Structures
Structure, 18, 2010
7JVO
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Importin alpha bound to the C-terminus of ACE2
分子名称: ARG-LYS-LYS-LYS-ASN-LYS-ALA, Importin subunit alpha-1
著者Forwood, J.K, Cross, E.M, Tsimbalyuk, S.
登録日2020-08-22
公開日2020-10-14
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Targeting novel LSD1-dependent ACE2 demethylation domains inhibits SARS-CoV-2 replication.
Cell Discov, 7, 2021
6UDS
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BU of 6uds by Molmil
Crystal structure of a putative 3-oxoacyl-ACP reductase (FabG) from Acinetobacter baumannii
分子名称: 3-oxoacyl-(Acyl-carrier-protein) reductase
著者Forwood, J.K, Cross, E.M.
登録日2019-09-19
公開日2019-10-09
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Insights into Acinetobacter baumannii fatty acid synthesis 3-oxoacyl-ACP reductases.
Sci Rep, 11, 2021
6RPK
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non-expanded bat circovirus with DNA VLP
分子名称: Capsid protein
著者Forwood, J.K, Luque, D, Mata, C.P, Das, S, Raidal, S.
登録日2019-05-14
公開日2020-11-25
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (2.84 Å)
主引用文献non-expanded bat circovirus with DNA VLP
To Be Published
6RPO
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bat circovirus without DNA VLP
分子名称: bat circovirus capsid protein
著者Forwood, J.K, Luque, D, Mata, C.P, Das, S, Raidal, S.
登録日2019-05-14
公開日2020-11-25
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (2.39 Å)
主引用文献bat circovirus without DNA VLP
To Be Published
6RPL
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Expanded bat circovirus with DNA VLP
分子名称: Capsid protein
著者Forwood, J.K, Luque, D, Mata, C.P, Das, S, Raidal, S.
登録日2019-05-14
公開日2020-11-25
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (3.85 Å)
主引用文献expanded bat circovirus with DNA VLP
To Be Published
3SPS
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BU of 3sps by Molmil
Crystal Structure of Apo-Hexameric Acyl-CoA Thioesterase
分子名称: Acyl-CoA hydrolase
著者Forwood, J.K, Marfori, M, Kobe, B.
登録日2011-07-03
公開日2011-08-17
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Ligand-Induced Conformational Changes within a Hexameric Acyl-CoA Thioesterase
To be Published
8ECH
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BU of 8ech by Molmil
Tick-borne encephalitis virus capsid protein NLS bound to host importin alpha 2
分子名称: Capsid protein C, Importin subunit alpha-1
著者Roby, J.A, Forwood, J.K.
登録日2022-09-02
公開日2022-09-14
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structure and biological functions of tick-borne encephalitis virus capsid protein
To Be Published
7N8J
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BU of 7n8j by Molmil
Human importin alpha 1 in complex with Bimax2 peptide
分子名称: BIMAX2, Importin subunit alpha-1
著者Donnelly, C.M, Cross, E.M, Tsimbalyuk, S, Forwood, J.K.
登録日2021-06-15
公開日2021-06-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Human importin alpha 1:Bimax2 peptide complex
To Be Published
8F2Q
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BU of 8f2q by Molmil
Human Parvovirus B19 Nonstructural NS1 Protein NLS bound to Importin Alpha 2
分子名称: Importin subunit alpha-1, Initiator protein NS1
著者Cross, E.M, Forwood, J.K.
登録日2022-11-08
公開日2023-05-03
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Importin alpha / beta-dependent nuclear transport of human parvovirus B19 nonstructural protein 1 is essential for viral replication.
Antiviral Res., 213, 2023
2OPC
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BU of 2opc by Molmil
Structure of Melampsora lini avirulence protein, AvrL567-A
分子名称: AvrL567-A, COBALT (II) ION, IMIDAZOLE
著者Guncar, G, Wang, C.I, Forwood, J.K, Teh, T, Catanzariti, A.M, Ellis, J.G, Dodds, P.N, Kobe, B.
登録日2007-01-29
公開日2007-03-06
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.43 Å)
主引用文献The use of Co2+ for crystallization and structure determination, using a conventional monochromatic X-ray source, of flax rust avirulence protein.
Acta Crystallogr.,Sect.F, 63, 2007
7JJM
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BU of 7jjm by Molmil
Crystal structure of Importin alpha 2 in complex with LSD1 NLS
分子名称: CHLORIDE ION, Importin subunit alpha-1, Lysine-specific histone demethylase 1A
著者Tu, W.J, McGuaig, R, Tan, H.Y.A, Hardy, C, Seddiki, N, Ali, S, Dahlstrom, J.E, Bean, E.G, Dunn, J, Forwood, J.K, Tsimbalyuk, S, Smith, K.M, Yip, D, Malik, L, Prasana, T, Milburn, P, Rao, S.
登録日2020-07-27
公開日2020-08-05
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch.
Front Immunol, 11, 2020
8SG7
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BU of 8sg7 by Molmil
Adeno-Associated Virus Bat origin capsid protein basic regions in complex with importin-alpha 2
分子名称: Importin subunit alpha-1, VP1 capsid
著者Hoad, M, Forwood, J.K.
登録日2023-04-11
公開日2023-07-19
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis for nuclear import of bat adeno-associated virus capsid protein.
J.Gen.Virol., 105, 2024
5KLT
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BU of 5klt by Molmil
Prototypical P4[M]cNLS
分子名称: Importin subunit alpha-1, Prototypical P4[M]cNLS
著者Smith, K.M, Forwood, J.K.
登録日2016-06-25
公開日2016-07-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Contribution of the residue at position 4 within classical nuclear localization signals to modulating interaction with importins and nuclear targeting.
Biochim Biophys Acta Mol Cell Res, 1865, 2018
5KLR
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BU of 5klr by Molmil
Prototypical P4[R]cNLS
分子名称: Importin subunit alpha-1, Prototypical P4[R]cNLS
著者Smith, K.M, Forwood, J.K.
登録日2016-06-25
公開日2016-07-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Contribution of the residue at position 4 within classical nuclear localization signals to modulating interaction with importins and nuclear targeting.
Biochim Biophys Acta Mol Cell Res, 1865, 2018
6W0L
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BU of 6w0l by Molmil
Henipavirus W protein interacts with 14-3-3 to modulate host gene expression
分子名称: 14-3-3 protein sigma, CALCIUM ION, Phosphorylated W peptide
著者Edwards, M, Hoad, M, Tsimbalyuk, S, Menicucci, A, Messaoudi, I, Forwood, J, Basler, C.
登録日2020-03-01
公開日2020-04-22
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Henipavirus W Proteins Interact with 14-3-3 To Modulate Host Gene Expression.
J.Virol., 94, 2020
2QVT
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BU of 2qvt by Molmil
Structure of Melampsora lini avirulence protein, AvrL567-D
分子名称: AvrL567-D
著者Guncar, G, Wang, C.I, Forwood, J.K, Teh, T, Catanzariti, A.M, Lawrence, G, Schirra, H.J, Anderson, P.A, Ellis, J.G, Dodds, P.N, Kobe, B.
登録日2007-08-08
公開日2007-10-30
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Crystal structures of flax rust avirulence proteins AvrL567-A and -D reveal details of the structural basis for flax disease resistance specificity.
Plant Cell, 19, 2007
7JJL
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BU of 7jjl by Molmil
Crystal structure of Importin Alpha 3 in complex with human LSD1 NLS
分子名称: Importin subunit alpha-3, Lysine-specific histone demethylase 1A
著者Tu, W.J, McCuaig, R, Tan, H.Y.A, Hardy, K, Seddiki, N, Ali, S, Dahlstrom, J.E, Bean, E.G, Dunn, J, Forwood, J.K, Tsimbalyuk, S, Smith, K, Yip, D, Malik, L, Prasana, T, Milburn, P, Rao, S.
登録日2020-07-27
公開日2020-08-05
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch.
Front Immunol, 11, 2020
7JK7
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BU of 7jk7 by Molmil
Crystal structure of Importin alpha 2 in complex with LSD1 NLS S111E mutant
分子名称: GLYCEROL, Importin subunit alpha-1, Lysine-specific histone demethylase 1A
著者Tu, W.J, McCuaig, R, Tan, A.H.Y, Hardy, K, Seddiki, N, Ali, S, Dahlstron, J.E, Bean, E.G, Dunn, J, Forwood, J.K, Tsimbalyuk, S, Smith, K.M, Yip, D, Malik, L, Prasana, T, Milburn, P, Rao, S.
登録日2020-07-27
公開日2020-08-05
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch.
Front Immunol, 11, 2020
6PZN
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BU of 6pzn by Molmil
Putative SDR from Acinetobacter baumannii Crystal Form 2
分子名称: 3-ketoacyl-ACP reductase
著者Cross, E.M, Aragao, D, Forwood, J.K.
登録日2019-08-01
公開日2019-08-14
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural characterization of a short-chain dehydrogenase/reductase from multi-drug resistant Acinetobacter baumannii.
Biochem.Biophys.Res.Commun., 518, 2019
6PZM
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BU of 6pzm by Molmil
Putative SDR from Acinetobacter baumannii Crystal Form 1
分子名称: 3-ketoacyl-ACP reductase
著者Cross, E.M, Aragao, D, Forwood, J.K.
登録日2019-08-01
公開日2019-08-14
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural characterization of a short-chain dehydrogenase/reductase from multi-drug resistant Acinetobacter baumannii.
Biochem.Biophys.Res.Commun., 518, 2019
2Q2B
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BU of 2q2b by Molmil
Crystal structure of the C-terminal domain of mouse acyl-CoA thioesterase 7
分子名称: Cytosolic acyl coenzyme A thioester hydrolase
著者Guncar, G, Forwood, J.K, Kobe, B.
登録日2007-05-27
公開日2007-07-17
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis for recruitment of tandem hotdog domains in acyl-CoA thioesterase 7 and its role in inflammation.
Proc.Natl.Acad.Sci.Usa, 104, 2007
8TUR
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BU of 8tur by Molmil
Merkel Cell Polyomavirus LTA bipartite NLS bound to importin alpha 2
分子名称: Importin subunit alpha-1, Truncated large T antigen
著者Cross, E.M, Forwood, J.K, Alvisi, G.
登録日2023-08-17
公開日2024-02-07
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals.
Protein Sci., 33, 2024

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件を2024-05-22に公開中

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