5VFH
 
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5VFJ
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5VQI
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4WTB
 | | BthTX-I, a svPLA2s-like toxin, complexed with zinc ions | | Descriptor: | Basic phospholipase A2 homolog bothropstoxin-1, CHLORIDE ION, SULFATE ION, ... | | Authors: | Borges, R.J, Fontes, M.R.M. | | Deposit date: | 2014-10-29 | | Release date: | 2015-11-11 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.16 Å) | | Cite: | Functional and structural studies of a Phospholipase A2-like protein complexed to zinc ions: Insights on its myotoxicity and inhibition mechanism.
Biochim. Biophys. Acta, 1861, 2017
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5VFN
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1M05
 | | HLA B8 in complex with an Epstein Barr Virus determinant | | Descriptor: | Beta-2-microglobulin, CADMIUM ION, EBNA-3 nuclear protein, ... | | Authors: | Kjer-Nielsen, L, Clements, C.S, Brooks, A.G, Purcell, A.W, Fontes, M.R, McCluskey, J, Rossjohn, J. | | Deposit date: | 2002-06-11 | | Release date: | 2003-09-02 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The structure of HLA-B8 complexed to an immunodominant viral determinant: peptide-induced conformational changes and
a mode of MHC class I dimerization.
J.IMMUNOL., 169, 2003
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7RJI
 | | BthTX-II variant b, from Bothrops jararacussu venom, complexed with stearic acid | | Descriptor: | BthTX-IIb, SODIUM ION, STEARIC ACID, ... | | Authors: | Borges, R.J, Fontes, M.R.M. | | Deposit date: | 2021-07-21 | | Release date: | 2022-01-05 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.71 Å) | | Cite: | BthTX-II from Bothrops jararacussu venom has variants with different oligomeric assemblies: An example of snake venom phospholipases A 2 versatility.
Int.J.Biol.Macromol., 191, 2021
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7RJZ
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7ROX
 | | BthTX-I complexed with inhibitor MMV | | Descriptor: | 12-methoxy-Nb-methylvoachalotine, Basic phospholipase A2 homolog bothropstoxin-I | | Authors: | Borges, R.J, De Marino, I, Uson, I, Fontes, M.R.M. | | Deposit date: | 2021-08-02 | | Release date: | 2022-11-09 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural and functional studies of a snake venom phospholipase A 2 -like protein complexed to an inhibitor from Tabernaemontana catharinensis.
Biochimie, 206, 2023
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1PA0
 | | CRYSTAL STRUCTURE OF BNSP-7, A LYS49-PHOSPHOLIPASE A2 | | Descriptor: | Myotoxic phospholipase A2-like | | Authors: | Magro, A.J, Soares, A.M, Giglio, J.R, Fontes, M.R. | | Deposit date: | 2003-05-13 | | Release date: | 2004-07-27 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structures of BnSP-7 and BnSP-6, two Lys49-phospholipases A(2): quaternary structure and inhibition mechanism insights.
Biochem.Biophys.Res.Commun., 311, 2003
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3QNL
 | | Crystal structure of PrTX-I complexed to Rosmarinic Acid | | Descriptor: | (2R)-3-(3,4-dihydroxyphenyl)-2-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}propanoic acid, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, ISOPROPYL ALCOHOL, ... | | Authors: | dos Santos, J.I, Fontes, M.R.M. | | Deposit date: | 2011-02-08 | | Release date: | 2012-02-29 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Structural and Functional Studies of a Bothropic Myotoxin Complexed to Rosmarinic Acid: New Insights into Lys49-PLA(2) Inhibition.
Plos One, 6, 2011
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3RZX
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1DEA
 | | STRUCTURE AND CATALYTIC MECHANISM OF GLUCOSAMINE 6-PHOSPHATE DEAMINASE FROM ESCHERICHIA COLI AT 2.1 ANGSTROMS RESOLUTION | | Descriptor: | GLUCOSAMINE 6-PHOSPHATE DEAMINASE, PHOSPHATE ION | | Authors: | Oliva, G, Fontes, M.R.M, Garratt, R.C, Altamirano, M.M, Calcagno, M.L, Horjales, E. | | Deposit date: | 1995-09-13 | | Release date: | 1996-01-29 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structure and catalytic mechanism of glucosamine 6-phosphate deaminase from Escherichia coli at 2.1 A resolution.
Structure, 3, 1995
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6PWH
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4KF3
 | | Crystal Structure of Myotoxin II (MjTX-II), a myotoxic Lys49-phospholipase A2 from Bothrops moojeni. | | Descriptor: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Basic phospholipase A2 homolog 2, ISOPROPYL ALCOHOL | | Authors: | Salvador, G.H.M, dos Santos, J.I, Fontes, M.R.M. | | Deposit date: | 2013-04-26 | | Release date: | 2013-07-17 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.92 Å) | | Cite: | Structural and functional studies with mytoxin II from Bothrops moojeni reveal remarkable similarities and differences compared to other catalytically inactive phospholipases A2-like.
Toxicon, 72C, 2013
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1Z76
 | | Crystal structure of an acidic phospholipase A2 (BthA-I) from Bothrops jararacussu venom complexed with p-bromophenacyl bromide | | Descriptor: | p-Bromophenacyl bromide, phospholipase A2 | | Authors: | Magro, A.J, Takeda, A.A, Soares, A.M, Fontes, M.R. | | Deposit date: | 2005-03-24 | | Release date: | 2006-03-21 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structure of BthA-I complexed with p-bromophenacyl bromide: possible correlations with lack of pharmacological activity.
Acta Crystallogr.,Sect.D, 61, 2005
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7LYE
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7M60
 | | Structure of Mouse Importin alpha MLH1-S467A NLS Peptide Complex | | Descriptor: | DNA mismatch repair protein Mlh1 NLS peptide, Importin subunit alpha-1 | | Authors: | De Oliveira, H.C, Da Silva, T.D, Fukuda, C.A, Fontes, M.R.M. | | Deposit date: | 2021-03-25 | | Release date: | 2021-07-07 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural and calorimetric studies reveal specific determinants for the binding of a high-affinity NLS to mammalian importin-alpha.
Biochem.J., 478, 2021
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3JR8
 | | Crystal Structure of BthTX-II (Asp49-PLA2 from Bothrops jararacussu snake venom) with calcium ions | | Descriptor: | CALCIUM ION, Phospholipase A2 bothropstoxin-2 | | Authors: | Borges, R.J, dos Santos, J.I, Fontes, M.R.M. | | Deposit date: | 2009-09-08 | | Release date: | 2010-09-08 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural, functional, and bioinformatics studies reveal a new snake venom homologue phospholipase A2 class.
Proteins, 79, 2011
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5TFV
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4K09
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4K06
 | | Crystal structure of MTX-II from Bothrops brazili venom complexed with polyethylene glycol | | Descriptor: | 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, MTX-II, ... | | Authors: | Fernandes, C.A.H, Comparetti, E.J, Borges, R.J, Fontes, M.R.M. | | Deposit date: | 2013-04-03 | | Release date: | 2013-11-13 | | Last modified: | 2013-11-27 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | Structural bases for a complete myotoxic mechanism: Crystal structures of two non-catalytic phospholipases A2-like from Bothrops brazili venom.
Biochim.Biophys.Acta, 1834, 2013
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1XXS
 | | Structural insights for fatty acid binding in a Lys49 phospholipase A2: crystal structure of myotoxin II from Bothrops moojeni complexed with stearic acid | | Descriptor: | Phospholipase A2 homolog 2, STEARIC ACID, SULFATE ION | | Authors: | Watanabe, L, Soares, A.M, Ward, R.J, Fontes, M.R, Arni, R.K. | | Deposit date: | 2004-11-08 | | Release date: | 2005-03-29 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural insights for fatty acid binding in a Lys49-phospholipase A(2): crystal structure of myotoxin II from Bothrops moojeni complexed with stearic acid
Biochimie, 87, 2005
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3RZ9
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2OK9
 | | PrTX-I-BPB | | Descriptor: | ISOPROPYL ALCOHOL, Phospholipase A2 homolog 1, p-Bromophenacyl bromide | | Authors: | Marchi-Salvador, D.P, Fernandes, C.A.H, Soares, A.M, Fontes, M.R. | | Deposit date: | 2007-01-16 | | Release date: | 2008-09-23 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.34 Å) | | Cite: | Crystal structure of a phospholipase A(2) homolog complexed with p-bromophenacyl bromide reveals important structural changes associated with the inhibition of myotoxic activity.
Biochim.Biophys.Acta, 1794, 2009
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