4IMG
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4IMD
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4IMC
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4IMF
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4IME
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2NN3
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![BU of 2nn3 by Molmil](/molmil-images/mine/2nn3) | structure of pro-sf-caspase-1 | Descriptor: | Caspase-1 | Authors: | Fisher, A.J, Ni, L. | Deposit date: | 2006-10-23 | Release date: | 2007-10-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Pro-sfcapsase-1, structural insights into activation mechanism of caspases To be Published
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6CKL
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![BU of 6ckl by Molmil](/molmil-images/mine/6ckl) | N. meningitidis CMP-sialic acid synthetase in the presence of CMP and Neu5Ac2en | Descriptor: | 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, CHLORIDE ION, CITRATE ANION, ... | Authors: | Matthews, M.M, Fisher, A.J, Chen, X. | Deposit date: | 2018-02-28 | Release date: | 2019-03-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.684 Å) | Cite: | Catalytic Cycle ofNeisseria meningitidisCMP-Sialic Acid Synthetase Illustrated by High-Resolution Protein Crystallography. Biochemistry, 2019
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4DBC
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![BU of 4dbc by Molmil](/molmil-images/mine/4dbc) | Substrate Activation in Aspartate Aminotransferase | Descriptor: | (E)-N-{2-hydroxy-3-methyl-6-[(phosphonooxy)methyl]benzylidene}-L-aspartic acid, 1,2-ETHANEDIOL, Aspartate aminotransferase, ... | Authors: | Toney, M.D, Fisher, A.J, Griswold, W.R. | Deposit date: | 2012-01-14 | Release date: | 2012-12-05 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Ground-state electronic destabilization via hyperconjugation in aspartate aminotransferase. J.Am.Chem.Soc., 134, 2012
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2IIQ
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5XEP
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![BU of 5xep by Molmil](/molmil-images/mine/5xep) | Crystal structure of BRP39, a chitinase-like protein, at 2.6 Angstorm resolution | Descriptor: | 1,2-ETHANEDIOL, Chitinase-3-like protein 1 | Authors: | Mohanty, A.K, Fisher, A.J, Choudhary, S, Kaushik, J.K. | Deposit date: | 2017-04-05 | Release date: | 2018-04-11 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal Structure of BRP39, a signalling glycoprotein expressed during mammary gland apoptosis. To be published
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8E0F
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![BU of 8e0f by Molmil](/molmil-images/mine/8e0f) | Human Adenosine Deaminase Acting on dsRNA (ADAR2-RD) bound to dsRNA containing a G-G pair adjacent to the target site | Descriptor: | Double-stranded RNA-specific editase 1, INOSITOL HEXAKISPHOSPHATE, RNA (5-R(*GP*CP*UP*CP*GP*CP*GP*AP*UP*GP*CP*GP*(8AZ)P*GP*AP*GP*GP*GP*CP* UP*CP*UP*GP*AP*UP*AP*GP*CP*UP*AP*CP*G)-3), ... | Authors: | Wilcox, X.E, Fisher, A.J, Beal, P.A. | Deposit date: | 2022-08-09 | Release date: | 2022-10-26 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | ADAR activation by inducing a syn conformation at guanosine adjacent to an editing site. Nucleic Acids Res., 50, 2022
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5HP2
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![BU of 5hp2 by Molmil](/molmil-images/mine/5hp2) | Human Adenosine Deaminase Acting on dsRNA (ADAR2) bound to dsRNA sequence derived from S. cerevisiae BDF2 gene with AU basepair at reaction site | Descriptor: | Double-stranded RNA-specific editase 1, INOSITOL HEXAKISPHOSPHATE, RNA (5'-R(*GP*AP*CP*UP*GP*AP*AP*CP*GP*AP*CP*UP*AP*AP*UP*GP*UP*GP*GP*GP*GP*AP*A)-3'), ... | Authors: | Matthews, M.M, Fisher, A.J, Beal, P.A. | Deposit date: | 2016-01-20 | Release date: | 2016-04-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.983 Å) | Cite: | Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity. Nat.Struct.Mol.Biol., 23, 2016
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5HP3
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![BU of 5hp3 by Molmil](/molmil-images/mine/5hp3) | Human Adenosine Deaminase Acting on dsRNA (ADAR2) bound to dsRNA sequence derived from S. cerevisiae BDF2 gene with AC mismatch at reaction site | Descriptor: | Double-stranded RNA-specific editase 1, INOSITOL HEXAKISPHOSPHATE, RNA (5'-R(*GP*AP*CP*UP*GP*AP*AP*CP*GP*AP*CP*CP*AP*AP*UP*GP*UP*GP*GP*GP*GP*AP*A)-3'), ... | Authors: | Matthews, M.M, Fisher, A.J, Beal, P.A. | Deposit date: | 2016-01-20 | Release date: | 2016-04-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.091 Å) | Cite: | Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity. Nat.Struct.Mol.Biol., 23, 2016
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6PER
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![BU of 6per by Molmil](/molmil-images/mine/6per) | Crystal Structure of Ligand-Free iSeroSnFR | Descriptor: | 1,2-ETHANEDIOL, iSeroSnFR, a soluble, ... | Authors: | Hartanto, S, Tian, L, Fisher, A.J. | Deposit date: | 2019-06-20 | Release date: | 2020-06-24 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning. Cell, 183, 2020
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7KFN
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![BU of 7kfn by Molmil](/molmil-images/mine/7kfn) | Structure of Human Adenosine Deaminase Acting on dsRNA (ADAR2) bound to dsRNA containing a 2'-deoxy Benner's Base Z opposite the edited base | Descriptor: | Double-stranded RNA-specific editase 1, Gli1 1W5 23mer RNA, Gli1 8AZ 23mer RNA, ... | Authors: | Wilcox, X.E, Fisher, A.J, Beal, P.A. | Deposit date: | 2020-10-14 | Release date: | 2021-06-16 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Rational Design of RNA Editing Guide Strands: Cytidine Analogs at the Orphan Position. J.Am.Chem.Soc., 143, 2021
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1I3S
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![BU of 1i3s by Molmil](/molmil-images/mine/1i3s) | THE 2.7 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF A MUTATED BACULOVIRUS P35 AFTER CASPASE CLEAVAGE | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, EARLY 35 KDA PROTEIN | Authors: | dela Cruz, W.P, Lemongello, D, Friesen, P.D, Fisher, A.J. | Deposit date: | 2001-02-15 | Release date: | 2001-10-24 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of baculovirus P35 reveals a novel conformational change in the reactive site loop after caspase cleavage. J.Biol.Chem., 276, 2001
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3ZHH
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![BU of 3zhh by Molmil](/molmil-images/mine/3zhh) | X-ray structure of the full-length beta-lactamase from M.tuberculosis | Descriptor: | BETA-LACTAMASE, SULFATE ION | Authors: | Feiler, C, Fisher, A.C, Marrichi, M.J, Wright, L, Schmidpeter, P.A.M, Blankenfeldt, W, Pavelka, M, DeLisa, M.P. | Deposit date: | 2012-12-21 | Release date: | 2013-09-25 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Directed Evolution of Mycobacterium Tuberculosis Beta-Lactamase Reveals Gatekeeper Residue that Regulates Antibiotic Resistance and Catalytic Efficiency. Plos One, 8, 2013
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1I3P
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3CS1
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![BU of 3cs1 by Molmil](/molmil-images/mine/3cs1) | Flagellar Calcium-binding Protein (FCaBP) from T. cruzi | Descriptor: | Flagellar calcium-binding protein | Authors: | Ames, J.B, Ladner, J.E, Wingard, J.N, Robinson, H, Fisher, A. | Deposit date: | 2008-04-08 | Release date: | 2008-06-24 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Insights into Membrane Targeting by the Flagellar Calcium-binding Protein (FCaBP), a Myristoylated and Palmitoylated Calcium Sensor in Trypanosoma cruzi. J.Biol.Chem., 283, 2008
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6XHG
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![BU of 6xhg by Molmil](/molmil-images/mine/6xhg) | Far-red absorbing dark state of JSC1_58120g3 with bound biliverdin IXa (BV) | Descriptor: | 1,2-ETHANEDIOL, 3-[2-[(~{Z})-[5-[(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-pyrrol-2-ylidene]methyl]-5-[(~{Z})-(3-ethyl-4-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-1~{H}-pyrrol-3-yl]propanoic acid, JSC1_58120g3 | Authors: | Moreno, M.V, Rockwell, N.C, Fisher, A.J, Lagarias, J.C. | Deposit date: | 2020-06-18 | Release date: | 2020-10-28 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A far-red cyanobacteriochrome lineage specific for verdins. Proc.Natl.Acad.Sci.USA, 117, 2020
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4R36
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![BU of 4r36 by Molmil](/molmil-images/mine/4r36) | Crystal structure analysis of LpxA, a UDP-N-acetylglucosamine acyltransferase from Bacteroides fragilis 9343 | Descriptor: | 2-(2-METHOXYETHOXY)ETHANOL, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, ACETATE ION, ... | Authors: | Ngo, A, Fong, K, Cox, D, Fisher, A, Chen, X. | Deposit date: | 2014-08-14 | Release date: | 2015-05-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structures of Bacteroides fragilis uridine 5'-diphosphate-N-acetylglucosamine (UDP-GlcNAc) acyltransferase (BfLpxA). Acta Crystallogr.,Sect.D, 71, 2015
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6XHH
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![BU of 6xhh by Molmil](/molmil-images/mine/6xhh) | Far-red absorbing dark state of JSC1_58120g3 with bound 18-1, 18-2 dihydrobiliverdin IXa (DHBV), the native chromophore precursor | Descriptor: | 1,2-ETHANEDIOL, JSC1_58120g3, mesobiliverdin IX(alpha) | Authors: | Moreno, M.V, Rockwell, N.C, Fisher, A.J, Lagarias, J.C. | Deposit date: | 2020-06-18 | Release date: | 2020-10-28 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | A far-red cyanobacteriochrome lineage specific for verdins. Proc.Natl.Acad.Sci.USA, 117, 2020
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6VFF
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![BU of 6vff by Molmil](/molmil-images/mine/6vff) | Dimer of Human Adenosine Deaminase Acting on dsRNA (ADAR2) mutant E488Q bound to dsRNA sequence derived from human GLI1 gene | Descriptor: | Double-stranded RNA-specific editase 1, INOSITOL HEXAKISPHOSPHATE, RNA (5-R(*GP*CP*UP*CP*GP*CP*GP*AP*UP*GP*CP*UP*(8AZ)P*GP*AP*GP*GP*GP*CP* UP*CP*UP*GP*AP*UP*AP*GP*CP*UP*AP*CP*G)-3), ... | Authors: | Thuy-boun, A.S, Fisher, A.J, Beal, P.A. | Deposit date: | 2020-01-03 | Release date: | 2020-07-01 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Asymmetric dimerization of adenosine deaminase acting on RNA facilitates substrate recognition. Nucleic Acids Res., 48, 2020
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1AFT
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![BU of 1aft by Molmil](/molmil-images/mine/1aft) | SMALL SUBUNIT C-TERMINAL INHIBITORY PEPTIDE OF MOUSE RIBONUCLEOTIDE REDUCTASE AS BOUND TO THE LARGE SUBUNIT, NMR, 26 STRUCTURES | Descriptor: | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE | Authors: | Laub, P.B, Fisher, A.L, Furst, G.T, Barwis, B.A, Hamann, C.S, Cooperman, B.S. | Deposit date: | 1997-03-13 | Release date: | 1997-05-15 | Last modified: | 2017-11-29 | Method: | SOLUTION NMR | Cite: | NMR structure of an inhibitory R2 C-terminal peptide bound to mouse ribonucleotide reductase R1 subunit. Nat.Struct.Biol., 2, 1995
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1SZU
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![BU of 1szu by Molmil](/molmil-images/mine/1szu) | The structure of gamma-aminobutyrate aminotransferase mutant: V241A | Descriptor: | 1,2-ETHANEDIOL, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, 4-aminobutyrate aminotransferase, ... | Authors: | Liu, W, Peterson, P.E, Langston, J.A, Jin, X, Zhou, X, Fisher, A.J, Toney, M.D. | Deposit date: | 2004-04-06 | Release date: | 2005-03-01 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Kinetic and Crystallographic Analysis of Active Site Mutants of Escherichia coligamma-Aminobutyrate Aminotransferase. Biochemistry, 44, 2005
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