6VFF

Dimer of Human Adenosine Deaminase Acting on dsRNA (ADAR2) mutant E488Q bound to dsRNA sequence derived from human GLI1 gene

Summary for 6VFF

• Entry DOI: 10.2210/pdb6vff/pdb
• Descriptor: Double-stranded RNA-specific editase 1, RNA (5-R(*GP*CP*UP*CP*GP*CP*GP*AP*UP*GP*CP*UP*(8AZ)P*GP*AP*GP*GP*GP*CP* UP*CP*UP*GP*AP*UP*AP*GP*CP*UP*AP*CP*G)-3), RNA(5-R(*CP*GP*UP*AP*GP*CP*UP*AP*UP*CP*AP*GP*AP*GP*CP*CP*CP*CP*CP*CP*AP*GP*CP*AP*UP*CP*GP*CP*GP*AP*GP*C)-3), ... (6 entities in total)
• Functional Keywords: protein-rna complex, hydrolase, hydrolase-rna complex, hydrolase/rna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 129959.62

Authors

Thuy-boun, A.S.,Fisher, A.J.,Beal, P.A. (deposition date: 2020-01-03, release date: 2020-07-01, Last modification date: 2023-10-11)

• Primary citation: Thuy-Boun, A.S.,Thomas, J.M.,Grajo, H.L.,Palumbo, C.M.,Park, S.,Nguyen, L.T.,Fisher, A.J.,Beal, P.A.; Asymmetric dimerization of adenosine deaminase acting on RNA facilitates substrate recognition.; Nucleic Acids Res., 48:7958-7972, 2020; PubMed: 32597966; DOI: 10.1093/nar/gkaa532

Experimental method

X-RAY DIFFRACTION (2.8 Å)