6VFF
Dimer of Human Adenosine Deaminase Acting on dsRNA (ADAR2) mutant E488Q bound to dsRNA sequence derived from human GLI1 gene
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Double-stranded RNA-specific editase 1 | polymer | 488 | 53989.7 | 2 | UniProt (P78563) Pfam (PF00035) Pfam (PF02137) | Homo sapiens (Human) | RNA-editing deaminase 1,RNA-editing enzyme 1,dsRNA adenosine deaminase |
| 2 | C (C) | RNA (5-R(*GP*CP*UP*CP*GP*CP*GP*AP*UP*GP*CP*UP*(8AZ)P*GP*AP*GP*GP*GP*CP* UP*CP*UP*GP*AP*UP*AP*GP*CP*UP*AP*CP*G)-3) | polymer | 32 | 10316.1 | 1 | Homo sapiens | ||
| 3 | D (D) | RNA(5-R(*CP*GP*UP*AP*GP*CP*UP*AP*UP*CP*AP*GP*AP*GP*CP*CP*CP*CP*CP*CP*AP*GP*CP*AP*UP*CP*GP*CP*GP*AP*GP*C)-3) | polymer | 32 | 10213.2 | 1 | Homo sapiens | ||
| 4 | E, G (A, B) | INOSITOL HEXAKISPHOSPHATE | non-polymer | 660.0 | 2 | Chemie (IHP) | |||
| 5 | F, H (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 36 | Chemie (HOH) |
Sequence modifications
A, B: 215 - 701 (UniProt: P78563)
| PDB | External Database | Details |
|---|---|---|
| Gly 214 | - | expression tag |
| Gln 488 | Glu 516 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 128508.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1450.9 | |
| All* | Total formula weight | 129959.6 |
