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PDB: 34 results

5WB7
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Crystal structure of the epidermal growth factor receptor extracellular region in complex with epiregulin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, ...
Authors:Freed, D.M, Bessman, N.J, Ferguson, K.M, Lemmon, M.A.
Deposit date:2017-06-28
Release date:2017-10-18
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.941 Å)
Cite:EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics.
Cell, 171, 2017
5UTK
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Crystal structure of the membrane proximal three fibronectin type III (FNIII) domains of Tie2 (Tie2[FNIIIa-c])
Descriptor: Angiopoietin-1 receptor
Authors:Moore, J.O, Lemmon, M.A, Ferguson, K.M.
Deposit date:2017-02-15
Release date:2017-04-12
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Dimerization of Tie2 mediated by its membrane-proximal FNIII domains.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5WB8
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Crystal structure of the epidermal growth factor receptor extracellular region in complex with epigen
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, Epigen, ...
Authors:Bessman, N.J, Freed, D.M, Moore, J.O, Ferguson, K.M, Lemmon, M.A.
Deposit date:2017-06-28
Release date:2017-10-18
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3 Å)
Cite:EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics.
Cell, 171, 2017
1YY8
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Crystal structure of the Fab fragment from the monoclonal antibody cetuximab/Erbitux/IMC-C225
Descriptor: Cetuximab Fab Heavy chain, Cetuximab Fab Light chain
Authors:Li, S, Schmitz, K.R, Jeffrey, P.D, Wiltzius, J.J.W, Kussie, P, Ferguson, K.M.
Deposit date:2005-02-24
Release date:2005-04-26
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for inhibition of the epidermal growth factor receptor by cetuximab
Cancer Cell, 7, 2005
1YY9
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BU of 1yy9 by Molmil
Structure of the extracellular domain of the epidermal growth factor receptor in complex with the Fab fragment of cetuximab/Erbitux/IMC-C225
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cetuximab Fab Heavy chain, ...
Authors:Li, S, Schmitz, K.R, Jeffrey, P.D, Wiltzius, J.J.W, Kussie, P, Ferguson, K.M.
Deposit date:2005-02-24
Release date:2005-04-26
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.605 Å)
Cite:Structural basis for inhibition of the epidermal growth factor receptor by cetuximab
Cancer Cell, 7, 2005
2AHX
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Crystal structure of ErbB4/HER4 extracellular domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Receptor tyrosine-protein kinase erbB-4, SULFATE ION, ...
Authors:Bouyain, S, Longo, P.A, Li, S, Ferguson, K.M, Leahy, D.J.
Deposit date:2005-07-28
Release date:2005-09-27
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.396 Å)
Cite:The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand
Proc.Natl.Acad.Sci.USA, 102, 2005
8UKX
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Crystal structure the extracellular region of the epidermal growth factor receptor variant III (EGFRvIII) at pH 7.0
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Stayrook, S.E, Ferguson, K.M.
Deposit date:2023-10-15
Release date:2024-06-12
Method:X-RAY DIFFRACTION (3.301 Å)
Cite:Structural insights into the role and targeting of EGFRvIII
Structure, 2024
8UKV
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Crystal structure of nanobody/VHH domain of 34E5 in complex with the extracellular region of the epidermal growth factor variant III (EGFRvIII)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, ...
Authors:Stayrook, S.E, Ferguson, K.M, Bagchi, A.
Deposit date:2023-10-15
Release date:2024-06-19
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:Structural insights into the role and targeting of EGFRvIII
Structure, 2024
8UKW
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Crystal structure the extracellular region of the epidermal growth factor receptor variant III (EGFRvIII) at pH 5.0
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, ...
Authors:Stayrook, S.E, Ferguson, K.M.
Deposit date:2023-10-15
Release date:2024-06-12
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Structural insights into the role and targeting of EGFRvIII
Structure, 2024
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