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PDB: 20 件
6CBJ
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Crystal Structure of DH270.3 Fab in complex with Man9
分子名称: DH270.3 Fab heavy chain, DH270.3 Fab light chain, PHOSPHATE ION, ...
著者Fera, D, Harrison, S.C.
登録日2018-02-03
公開日2018-02-21
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope.
Nat Commun, 9, 2018
6CBP
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Crystal structure of the single chain variable fragment of the DH270.6 bnAb in complex with the Man9-V3 glycopeptide
分子名称: DH270.6 single chain variable fragment, Man9-V3 glycopeptide, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose, ...
著者Fera, D, Harrison, S.C.
登録日2018-02-03
公開日2018-02-21
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.17 Å)
主引用文献HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope.
Nat Commun, 9, 2018
5F6I
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Crystal Structure of Tier 2 Neutralizing Antibody DH428 from a Rhesus Macaque
分子名称: DH428 Antibody Heavy Chain, DH428 Antibody Light Chain
著者Fera, D, Harrison, S.C.
登録日2015-12-06
公開日2016-01-13
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site.
Cell Rep, 14, 2016
5F6H
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Crystal Structure of Tier 2 Neutralizing Antibody DH427 from a Rhesus Macaque
分子名称: DH427 Antibody Heavy Chain, DH427 Antibody Light Chain
著者Fera, D, Harrison, S.C.
登録日2015-12-06
公開日2016-01-13
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.66 Å)
主引用文献Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site.
Cell Rep, 14, 2016
5F6J
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Crystal Structure of Tier 2 Neutralizing Antibody DH427 from a Rhesus Macaque in Complex with HIV-1 gp120 Core
分子名称: DH427 Antibody Heavy Chain, DH427 Antibody Light Chain, ENVELOPE GLYCOPROTEIN GP120 of HIV-1 clade C
著者Fera, D, Harrison, S.C.
登録日2015-12-06
公開日2016-01-13
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (6.63 Å)
主引用文献Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site.
Cell Rep, 14, 2016
6VPY
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I33M (I3.2 mutant from CH103 Lineage)
分子名称: CHLORIDE ION, GLYCEROL, I33M heavy chain, ...
著者Fera, D, Zhou, J.
登録日2020-02-04
公開日2020-07-15
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.36 Å)
主引用文献The Effects of Framework Mutations at the Variable Domain Interface on Antibody Affinity Maturation in an HIV-1 Broadly Neutralizing Antibody Lineage.
Front Immunol, 11, 2020
5U0U
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BU of 5u0u by Molmil
Crystal Structure of DH270.1 (unliganded, single-chain Fv) from the DH270 Broadly Neutralizing N332-glycan Dependent Lineage
分子名称: DH270.1 single-chain variable fragment
著者Fera, D, Harrison, S.C.
登録日2016-11-27
公開日2017-03-15
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (3.428 Å)
主引用文献Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.
Sci Transl Med, 9, 2017
6VTU
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DH717.1 Fab monomer in complex with man9 glycan
分子名称: DH717.1 heavy chain, DH717.1 light chain, GLYCEROL, ...
著者Fera, D, Bronkema, N.
登録日2020-02-13
公開日2020-12-30
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies.
Cell, 184, 2021
5U15
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Crystal Structure of DH270.UCA3 (unliganded) from the DH270 Broadly Neutralizing N332-glycan Dependent Lineage
分子名称: DH270.UCA3 heavy chain, DH270.UCA3 light chain
著者Fera, D, Harrison, S.C.
登録日2016-11-27
公開日2017-03-15
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.
Sci Transl Med, 9, 2017
5TQA
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Crystal Structure of DH270.6 (unliganded) from the DH270 Broadly Neutralizing N332-Glycan Dependent Lineage
分子名称: DH270.6 Fab heavy chain, DH270.6 Fab light chain
著者Fera, D, Harrison, S.C.
登録日2016-10-23
公開日2017-03-15
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.723 Å)
主引用文献Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.
Sci Transl Med, 9, 2017
5U0R
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Crystal Structure of DH270.UCA1 (unliganded) from the DH270 Broadly Neutralizing N332-glycan Dependent Lineage
分子名称: DH270.UCA1 heavy chain, DH270.UCA1 light chain, SULFATE ION
著者Fera, D, Harrison, S.C.
登録日2016-11-26
公開日2017-03-15
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.295 Å)
主引用文献Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.
Sci Transl Med, 9, 2017
5TPL
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Crystal Structure of DH270.3 (unliganded) from the DH270 Broadly Neutralizing N332-glycan Dependent Lineage
分子名称: DH270.3 Fab heavy chain, DH270.3 Fab light chain
著者Fera, D, Harrison, S.C.
登録日2016-10-20
公開日2017-03-15
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.
Sci Transl Med, 9, 2017
5TPP
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BU of 5tpp by Molmil
Crystal Structure of DH270.5 (unliganded) from the DH270 Broadly Neutralizing N332-glycan Dependent Lineage
分子名称: CITRIC ACID, DH270.5 Fab heavy chain, DH270.5 Fab light chain, ...
著者Fera, D, Harrison, S.C.
登録日2016-10-20
公開日2017-03-15
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.
Sci Transl Med, 9, 2017
4QHN
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I2 (unbound) from CH103 Lineage
分子名称: I2 heavy chain, I2 light chain
著者Fera, D, Harrison, S.C.
登録日2014-05-28
公開日2014-06-11
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Affinity maturation in an HIV broadly neutralizing B-cell lineage through reorientation of variable domains.
Proc.Natl.Acad.Sci.USA, 111, 2014
5UIX
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BU of 5uix by Molmil
Crystal Structure of the DH576 CD4bs Fab (unliganded) from the RV305 HIV Vaccine Trial
分子名称: DH576 Fab heavy chain, DH576 Fab light chain
著者Fera, D, Harrison, S.C.
登録日2017-01-15
公開日2017-03-08
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.501 Å)
主引用文献Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial.
PLoS Pathog., 13, 2017
4QHK
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UCA (unbound) from CH103 Lineage
分子名称: UCA heavy chain, UCA light chain
著者Fera, D, Harrison, S.C.
登録日2014-05-28
公開日2014-06-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.487 Å)
主引用文献Affinity maturation in an HIV broadly neutralizing B-cell lineage through reorientation of variable domains.
Proc.Natl.Acad.Sci.USA, 111, 2014
5TRP
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BU of 5trp by Molmil
Crystal Structure of the Unliganded DH270 Cooperating Lineage Member DH272
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, DH272 Fab heavy chain, DH272 Fab light chain, ...
著者Fera, D, Harrison, S.C.
登録日2016-10-27
公開日2017-03-15
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.692 Å)
主引用文献Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.
Sci Transl Med, 9, 2017
4QHM
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BU of 4qhm by Molmil
I3.1 (unbound) from CH103 Lineage
分子名称: I2 light chain, I3 heavy chain
著者Fera, D, Harrison, S.C.
登録日2014-05-28
公開日2014-06-11
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (3.23 Å)
主引用文献Affinity maturation in an HIV broadly neutralizing B-cell lineage through reorientation of variable domains.
Proc.Natl.Acad.Sci.USA, 111, 2014
4QHL
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BU of 4qhl by Molmil
I3.2 (unbound) from CH103 Lineage
分子名称: I3 heavy chain, UCA light chain
著者Fera, D, Harrison, S.C.
登録日2014-05-28
公開日2014-06-11
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (3.153 Å)
主引用文献Affinity maturation in an HIV broadly neutralizing B-cell lineage through reorientation of variable domains.
Proc.Natl.Acad.Sci.USA, 111, 2014
8D3A
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BU of 8d3a by Molmil
Crystal Structure of DH475 Fab in complex with Man9
分子名称: DH475 Fab heavy chain, DH475 Fab light chain, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Finkelstein, M, Fera, D.
登録日2022-06-01
公開日2022-10-12
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Analysis of two cooperating antibodies unveils immune pressure imposed on HIV Env to elicit a V3-glycan supersite broadly neutralizing antibody lineage.
Front Immunol, 13, 2022

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件を2024-10-30に公開中

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