5UIX

Crystal Structure of the DH576 CD4bs Fab (unliganded) from the RV305 HIV Vaccine Trial

Summary for 5UIX

• Entry DOI: 10.2210/pdb5uix/pdb
• EMDB information: 8573
• Descriptor: DH576 Fab heavy chain, DH576 Fab light chain (3 entities in total)
• Functional Keywords: fab fragment, hiv-1, antibody, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 2
• Total formula weight: 48318.93

Authors

Fera, D.,Harrison, S.C. (deposition date: 2017-01-15, release date: 2017-03-08, Last modification date: 2023-10-04)

• Primary citation: Easterhoff, D.,Moody, M.A.,Fera, D.,Cheng, H.,Ackerman, M.,Wiehe, K.,Saunders, K.O.,Pollara, J.,Vandergrift, N.,Parks, R.,Kim, J.,Michael, N.L.,O'Connell, R.J.,Excler, J.L.,Robb, M.L.,Vasan, S.,Rerks-Ngarm, S.,Kaewkungwal, J.,Pitisuttithum, P.,Nitayaphan, S.,Sinangil, F.,Tartaglia, J.,Phogat, S.,Kepler, T.B.,Alam, S.M.,Liao, H.X.,Ferrari, G.,Seaman, M.S.,Montefiori, D.C.,Tomaras, G.D.,Harrison, S.C.,Haynes, B.F.; Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial.; PLoS Pathog., 13:e1006182-e1006182, 2017; PubMed: 28235027; DOI: 10.1371/journal.ppat.1006182

Experimental method

X-RAY DIFFRACTION (2.501 Å)