8D3A

Crystal Structure of DH475 Fab in complex with Man9

Summary for 8D3A

• Entry DOI: 10.2210/pdb8d3a/pdb
• Descriptor: DH475 Fab heavy chain, DH475 Fab light chain, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: fab fragment, hiv-1, antibody, immune system, immune system-antigen complex, immune system/antigen
• Biological source: Homo sapiens; More
• Total number of polymer chains: 2
• Total formula weight: 49497.60

Authors

Finkelstein, M.,Fera, D. (deposition date: 2022-06-01, release date: 2022-10-12, Last modification date: 2023-10-18)

• Primary citation: Finkelstein, M.T.,Parker Miller, E.,Erdman, M.C.,Fera, D.; Analysis of two cooperating antibodies unveils immune pressure imposed on HIV Env to elicit a V3-glycan supersite broadly neutralizing antibody lineage.; Front Immunol, 13:962939-962939, 2022; PubMed: 36225920; DOI: 10.3389/fimmu.2022.962939

Experimental method

X-RAY DIFFRACTION (2.9 Å)