5EZW
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8TFW
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5EFU
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8S9R
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![BU of 8s9r by Molmil](/molmil-images/mine/8s9r) | SAL2, Staphylococcus aureus lipase 2 (geh, lip2), apo form | Descriptor: | CALCIUM ION, Lipase 2, PHOSPHATE ION, ... | Authors: | Fellner, M. | Deposit date: | 2023-03-30 | Release date: | 2024-04-10 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | SAL2, Staphylococcus aureus lipase 2 (geh, lip2), apo form To Be Published
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8SBQ
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8TAV
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6VH9
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![BU of 6vh9 by Molmil](/molmil-images/mine/6vh9) | FphF, Staphylococcus aureus fluorophosphonate-binding serine hydrolases F, apo form | Descriptor: | Esterase family protein, SODIUM ION | Authors: | Fellner, M, Jamieson, S.A, Brewster, J.L, Mace, P.D. | Deposit date: | 2020-01-09 | Release date: | 2020-09-16 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Structural Basis for the Inhibitor and Substrate Specificity of the Unique Fph Serine Hydrolases of Staphylococcus aureus . Acs Infect Dis., 6, 2020
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6VHD
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6VHE
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6WCX
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6CF3
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![BU of 6cf3 by Molmil](/molmil-images/mine/6cf3) | Ethylene forming enzyme Y306A variant in complex with manganese and 2-oxoglutarate | Descriptor: | 1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, 2-oxoglutarate-dependent ethylene/succinate-forming enzyme, ... | Authors: | Fellner, M, Martinez, S, Hu, J, Hausinger, R.P. | Deposit date: | 2018-02-13 | Release date: | 2019-02-13 | Last modified: | 2024-04-17 | Method: | X-RAY DIFFRACTION (1.12 Å) | Cite: | Structural, Spectroscopic, and Computational Insights from Canavanine-Bound and Two Catalytically Compromised Variants of the Ethylene-Forming Enzyme. Biochemistry, 2024
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6CBA
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![BU of 6cba by Molmil](/molmil-images/mine/6cba) | Ethylene forming enzyme in complex with manganese, 2-oxoglutarate and canavanine | Descriptor: | 2-OXOGLUTARIC ACID, 2-oxoglutarate-dependent ethylene/succinate-forming enzyme, L-CANAVANINE, ... | Authors: | Fellner, M, Martinez, S, Hu, J, Hausinger, R.P. | Deposit date: | 2018-02-02 | Release date: | 2019-02-06 | Last modified: | 2024-04-17 | Method: | X-RAY DIFFRACTION (1.13 Å) | Cite: | Structural, Spectroscopic, and Computational Insights from Canavanine-Bound and Two Catalytically Compromised Variants of the Ethylene-Forming Enzyme. Biochemistry, 2024
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6C1W
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![BU of 6c1w by Molmil](/molmil-images/mine/6c1w) | A tethered niacin-derived pincer complex with a nickel-carbon or sulfite-carbon bond in lactate racemase | Descriptor: | (4S)-5-methanethioyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-4-sulfo-1,4-dihydropyridine-3-carbothioic S-acid, 3-methanethioyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium, Lactate racemase, ... | Authors: | Fellner, M, Desguin, B, Hausinger, R.P, Hu, J. | Deposit date: | 2018-01-05 | Release date: | 2018-03-14 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.398 Å) | Cite: | Lactate Racemase Nickel-Pincer Cofactor Operates by a Proton-Coupled Hydride Transfer Mechanism. Biochemistry, 57, 2018
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6BWQ
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![BU of 6bwq by Molmil](/molmil-images/mine/6bwq) | LarC2, the C-terminal domain of a cyclometallase involved in the synthesis of the NPN cofactor of lactate racemase, in complex with MnCTP | Descriptor: | CHLORIDE ION, CYTIDINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... | Authors: | Fellner, M, Hausinger, R.P, Hu, J. | Deposit date: | 2017-12-15 | Release date: | 2018-06-20 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Biosynthesis of the nickel-pincer nucleotide cofactor of lactate racemase requires a CTP-dependent cyclometallase. J. Biol. Chem., 293, 2018
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6UTR
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![BU of 6utr by Molmil](/molmil-images/mine/6utr) | LarE, a sulfur transferase involved in synthesis of the cofactor for lactate racemase in complex with copper | Descriptor: | ATP-dependent sacrificial sulfur transferase LarE, COPPER (II) ION, PHOSPHATE ION, ... | Authors: | Fellner, M, Huizenga, K, Hausinger, R.P, Hu, J. | Deposit date: | 2019-10-29 | Release date: | 2019-11-06 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Crystallographic characterization of a tri-Asp metal-binding site at the three-fold symmetry axis of LarE. Sci Rep, 10, 2020
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6UTQ
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![BU of 6utq by Molmil](/molmil-images/mine/6utq) | LarE, a sulfur transferase involved in synthesis of the cofactor for lactate racemase in complex with cadmium | Descriptor: | ATP-dependent sacrificial sulfur transferase LarE, CADMIUM ION, PHOSPHATE ION, ... | Authors: | Fellner, M, Huizenga, K, Hausinger, R.P, Hu, J. | Deposit date: | 2019-10-29 | Release date: | 2019-11-06 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Crystallographic characterization of a tri-Asp metal-binding site at the three-fold symmetry axis of LarE. Sci Rep, 10, 2020
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6UTT
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![BU of 6utt by Molmil](/molmil-images/mine/6utt) | LarE, a sulfur transferase involved in synthesis of the cofactor for lactate racemase in complex with calcium | Descriptor: | ATP-dependent sacrificial sulfur transferase LarE, CALCIUM ION, PHOSPHATE ION, ... | Authors: | Fellner, M, Huizenga, K, Hausinger, R.P, Hu, J. | Deposit date: | 2019-10-29 | Release date: | 2019-11-06 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Crystallographic characterization of a tri-Asp metal-binding site at the three-fold symmetry axis of LarE. Sci Rep, 10, 2020
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6B2O
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![BU of 6b2o by Molmil](/molmil-images/mine/6b2o) | LarE, a sulfur transferase involved in synthesis of the cofactor for lactate racemase, C176A variant | Descriptor: | ATP-utilizing enzyme of the PP-loopsuperfamily, PHOSPHATE ION, SULFATE ION | Authors: | Fellner, M, Hausinger, R.P, Hu, J. | Deposit date: | 2017-09-20 | Release date: | 2018-09-05 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Analysis of the Active Site Cysteine Residue of the Sacrificial Sulfur Insertase LarE from Lactobacillus plantarum. Biochemistry, 57, 2018
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6UTP
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![BU of 6utp by Molmil](/molmil-images/mine/6utp) | LarE, a sulfur transferase involved in synthesis of the cofactor for lactate racemase in complex with cobalt | Descriptor: | ATP-dependent sacrificial sulfur transferase LarE, COBALT (II) ION, PHOSPHATE ION, ... | Authors: | Fellner, M, Huizenga, K, Hausinger, R.P, Hu, J. | Deposit date: | 2019-10-29 | Release date: | 2019-11-06 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.55 Å) | Cite: | Crystallographic characterization of a tri-Asp metal-binding site at the three-fold symmetry axis of LarE. Sci Rep, 10, 2020
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6B2M
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![BU of 6b2m by Molmil](/molmil-images/mine/6b2m) | LarE, a sulfur transferase involved in synthesis of the cofactor for lactate racemase in complex with coenzyme A | Descriptor: | ATP-utilizing enzyme of the PP-loopsuperfamily, COENZYME A, PHOSPHATE ION | Authors: | Fellner, M, Hausinger, R.P, Hu, J. | Deposit date: | 2017-09-20 | Release date: | 2018-09-05 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.088 Å) | Cite: | Analysis of the Active Site Cysteine Residue of the Sacrificial Sulfur Insertase LarE from Lactobacillus plantarum. Biochemistry, 57, 2018
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6BWR
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![BU of 6bwr by Molmil](/molmil-images/mine/6bwr) | LarC2, the C-terminal domain of a cyclometallase involved in the synthesis of the NPN cofactor of lactate racemase, in complex with nickel | Descriptor: | NICKEL (II) ION, Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein | Authors: | Fellner, M, Hausinger, R.P, Hu, J. | Deposit date: | 2017-12-15 | Release date: | 2018-06-20 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Biosynthesis of the nickel-pincer nucleotide cofactor of lactate racemase requires a CTP-dependent cyclometallase. J. Biol. Chem., 293, 2018
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6BWO
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![BU of 6bwo by Molmil](/molmil-images/mine/6bwo) | LarC2, the C-terminal domain of a cyclometallase involved in the synthesis of the NPN cofactor of lactate racemase, apo form | Descriptor: | Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein | Authors: | Fellner, M, Desguin, B, Hausinger, R.P, Hu, J. | Deposit date: | 2017-12-15 | Release date: | 2018-06-20 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Biosynthesis of the nickel-pincer nucleotide cofactor of lactate racemase requires a CTP-dependent cyclometallase. J. Biol. Chem., 293, 2018
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5V2V
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![BU of 5v2v by Molmil](/molmil-images/mine/5v2v) | Ethylene forming enzyme in complex with nickel | Descriptor: | 2-oxoglutarate-dependent ethylene/succinate-forming enzyme, NICKEL (II) ION | Authors: | Fellner, M, Martinez, S, Hu, J, Hausinger, R.P. | Deposit date: | 2017-03-06 | Release date: | 2017-08-16 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.04 Å) | Cite: | Structures and Mechanisms of the Non-Heme Fe(II)- and 2-Oxoglutarate-Dependent Ethylene-Forming Enzyme: Substrate Binding Creates a Twist. J. Am. Chem. Soc., 139, 2017
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5FDB
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5UDQ
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![BU of 5udq by Molmil](/molmil-images/mine/5udq) | LarE, a sulfur transferase involved in synthesis of the cofactor for lactate racemase, apo form | Descriptor: | Lactate racemization operon protein LarE, PHOSPHATE ION, SULFATE ION | Authors: | Fellner, M, Desguin, B, Hausinger, R.P, Hu, J. | Deposit date: | 2016-12-28 | Release date: | 2017-08-23 | Last modified: | 2019-11-27 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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