1F0V
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![BU of 1f0v by Molmil](/molmil-images/mine/1f0v) | Crystal structure of an Rnase A dimer displaying a new type of 3D domain swapping | Descriptor: | 5'-D(*CP*G)-3', GLYCEROL, PHOSPHATE ION, ... | Authors: | Liu, Y.S, Gotte, G, Libonati, M, Eisenberg, D.S. | Deposit date: | 2000-05-17 | Release date: | 2001-02-21 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A domain-swapped RNase A dimer with implications for amyloid formation Nat.Struct.Biol., 8, 2001
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2A88
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![BU of 2a88 by Molmil](/molmil-images/mine/2a88) | Crystal structure of A Pantothenate synthetase, apo enzyme in C2 space group | Descriptor: | GLYCEROL, Pantoate--beta-alanine ligase, SULFATE ION | Authors: | Wang, S, Eisenberg, D, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2005-07-07 | Release date: | 2006-02-21 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal Structure of the Pantothenate Synthetase from Mycobacterium tuberculosis, Snapshots of the Enzyme in Action. Biochemistry, 45, 2006
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1AL1
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![BU of 1al1 by Molmil](/molmil-images/mine/1al1) | CRYSTAL STRUCTURE OF ALPHA1: IMPLICATIONS FOR PROTEIN DESIGN | Descriptor: | ALPHA HELIX PEPTIDE: ELLKKLLEELKG, SULFATE ION | Authors: | Hill, C.P, Anderson, D.H, Wesson, L, Degrado, W.F, Eisenberg, D. | Deposit date: | 1990-07-02 | Release date: | 1991-10-15 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of alpha 1: implications for protein design. Science, 249, 1990
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1DFN
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![BU of 1dfn by Molmil](/molmil-images/mine/1dfn) | CRYSTAL STRUCTURE OF DEFENSIN HNP-3, AN AMPHIPHILIC DIMER: MECHANISMS OF MEMBRANE PERMEABILIZATION | Descriptor: | DEFENSIN HNP-3 | Authors: | Hill, C.P, Yee, J, Selsted, M.E, Eisenberg, D. | Deposit date: | 1991-01-18 | Release date: | 1992-07-15 | Last modified: | 2017-11-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization. Science, 251, 1991
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3PPD
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![BU of 3ppd by Molmil](/molmil-images/mine/3ppd) | GGVLVN segment from Human Prostatic Acid Phosphatase Residues 260-265, involved in Semen-Derived Enhancer of Viral Infection | Descriptor: | ACETIC ACID, GGVLVN peptide, amyloid forming segment, ... | Authors: | Zhao, A, Sawaya, M.R, Eisenberg, D. | Deposit date: | 2010-11-24 | Release date: | 2011-06-29 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation. Nature, 475, 2011
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3NI3
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![BU of 3ni3 by Molmil](/molmil-images/mine/3ni3) | 54-Membered ring macrocyclic beta-sheet peptide | Descriptor: | 54-membered ring macrocyclic beta-sheet peptide, ISOPROPYL ALCOHOL | Authors: | Sawaya, M.R, Eisenberg, D, Nowick, J.S, Korman, T.P, Khakshoor, O. | Deposit date: | 2010-06-15 | Release date: | 2010-09-15 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.34 Å) | Cite: | X-ray crystallographic structure of an artificial beta-sheet dimer. J.Am.Chem.Soc., 132, 2010
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2OMM
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1S4Q
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![BU of 1s4q by Molmil](/molmil-images/mine/1s4q) | Crystal Structure of Guanylate Kinase from Mycobacterium tuberculosis (Rv1389) | Descriptor: | CHLORIDE ION, FORMIC ACID, Guanylate kinase | Authors: | Chan, S, Sawaya, M.R, Perry, L.J, Eisenberg, D, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2004-01-16 | Release date: | 2004-01-27 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Crystal Structure of Guanylate Kinase from Mycobacterium tuberculosis To be Published
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2QYG
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![BU of 2qyg by Molmil](/molmil-images/mine/2qyg) | Crystal Structure of a RuBisCO-like Protein rlp2 from Rhodopseudomonas palustris | Descriptor: | Ribulose bisphosphate carboxylase-like protein 2 | Authors: | Li, H, Chan, S, Tabita, F.R, Eisenberg, D. | Deposit date: | 2007-08-14 | Release date: | 2007-09-11 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Function, structure, and evolution of the RubisCO-like proteins and their RubisCO homologs. Microbiol.Mol.Biol.Rev., 71, 2007
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3T4G
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![BU of 3t4g by Molmil](/molmil-images/mine/3t4g) | AIIGLMV segment from Alzheimer's Amyloid-Beta displayed on 54-membered macrocycle scaffold | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Cyclic pseudo-peptide (ORN)AIIGLMV(ORN)KF(HAO)(4BF)K | Authors: | Zhao, M, Liu, C, Cheng, P.N, Eisenberg, D, Nowick, J.S. | Deposit date: | 2011-07-26 | Release date: | 2012-10-31 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Amyloid beta-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity. Nat Chem, 4, 2012
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1JBM
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4R0P
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1YJP
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![BU of 1yjp by Molmil](/molmil-images/mine/1yjp) | Structure of GNNQQNY from yeast prion Sup35 | Descriptor: | Eukaryotic peptide chain release factor GTP-binding subunit | Authors: | Nelson, R, Sawaya, M.R, Balbirnie, M, Madsen, A.O, Riekel, C, Grothe, R, Eisenberg, D. | Deposit date: | 2005-01-15 | Release date: | 2005-06-14 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of the cross-beta spine of amyloid-like fibrils. Nature, 435, 2005
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3Q9G
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![BU of 3q9g by Molmil](/molmil-images/mine/3q9g) | VQIVY segment from Alzheimer's tau displayed on 42-membered macrocycle scaffold | Descriptor: | ACETIC ACID, Cyclic pseudo-peptide VQIV(4BF)(ORN)(HAO)KL(ORN), GLYCEROL | Authors: | Liu, C, Sawaya, M.R, Eisenberg, D, Nowick, J.S, Cheng, P, Zheng, J. | Deposit date: | 2011-01-07 | Release date: | 2011-06-08 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Characteristics of Amyloid-Related Oligomers Revealed by Crystal Structures of Macrocyclic beta-Sheet Mimics. J.Am.Chem.Soc., 133, 2011
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3NVF
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3NVG
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1LU4
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![BU of 1lu4 by Molmil](/molmil-images/mine/1lu4) | 1.1 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF A SECRETED MYCOBACTERIUM TUBERCULOSIS DISULFIDE OXIDOREDUCTASE HOMOLOGOUS TO E. COLI DSBE: IMPLICATIONS FOR FUNCTIONS | Descriptor: | SOLUBLE SECRETED ANTIGEN MPT53 | Authors: | Goulding, C.W, Apostol, M.I, Gleiter, S, Parseghian, A, Bardwell, J, Gennaro, M, Eisenberg, D, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2002-05-21 | Release date: | 2003-10-14 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.12 Å) | Cite: | Gram-positive DsbE Proteins Function Differently from Gram-negative DsbE Homologs: A STRUCTURE TO FUNCTION ANALYSIS OF DsbE FROM MYCOBACTERIUM TUBERCULOSIS. J.Biol.Chem., 279, 2004
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1F1G
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![BU of 1f1g by Molmil](/molmil-images/mine/1f1g) | Crystal structure of yeast cuznsod exposed to nitric oxide | Descriptor: | COPPER (II) ION, COPPER-ZINC SUPEROXIDE DISMUTASE, PHOSPHATE ION, ... | Authors: | Hart, P.J, Ogihara, N.L, Liu, H, Nersissian, A.M, Valentine, J.S, Eisenberg, D. | Deposit date: | 2000-05-18 | Release date: | 2002-12-12 | Last modified: | 2017-10-04 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | A structure-based mechanism for copper-zinc superoxide dismutase. Biochemistry, 38, 1999
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1HTQ
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![BU of 1htq by Molmil](/molmil-images/mine/1htq) | Multicopy crystallographic structure of a relaxed glutamine synthetase from Mycobacterium tuberculosis | Descriptor: | ADENOSINE MONOPHOSPHATE, CITRIC ACID, MANGANESE (II) ION, ... | Authors: | Gill, H.S, Pfluegl, G.M, Eisenberg, D, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2001-01-01 | Release date: | 2002-07-24 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Multicopy crystallographic refinement of a relaxed glutamine synthetase from Mycobacterium tuberculosis highlights flexible loops in the enzymatic mechanism and its regulation. Biochemistry, 41, 2002
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3NVH
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3OVL
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![BU of 3ovl by Molmil](/molmil-images/mine/3ovl) | |
1JRI
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1EWF
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![BU of 1ewf by Molmil](/molmil-images/mine/1ewf) | THE 1.7 ANGSTROM CRYSTAL STRUCTURE OF BPI | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, BACTERICIDAL/PERMEABILITY-INCREASING PROTEIN | Authors: | Kleiger, G, Beamer, L.J, Grothe, R, Mallick, P, Eisenberg, D. | Deposit date: | 2000-04-25 | Release date: | 2000-06-21 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The 1.7 A crystal structure of BPI: a study of how two dissimilar amino acid sequences can adopt the same fold. J.Mol.Biol., 299, 2000
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1G6U
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![BU of 1g6u by Molmil](/molmil-images/mine/1g6u) | CRYSTAL STRUCTURE OF A DOMAIN SWAPPED DIMER | Descriptor: | DOMAIN SWAPPED DIMER, SULFATE ION, trifluoroacetic acid | Authors: | Ogihara, N.L, Ghirlanda, G, Bryson, J.W, Gingery, M, DeGrado, W.F, Eisenberg, D. | Deposit date: | 2000-11-07 | Release date: | 2001-02-21 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Design of three-dimensional domain-swapped dimers and fibrous oligomers. Proc.Natl.Acad.Sci.USA, 98, 2001
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1JS0
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![BU of 1js0 by Molmil](/molmil-images/mine/1js0) | Crystal Structure of 3D Domain-swapped RNase A Minor Trimer | Descriptor: | RIBONUCLEASE A, SULFATE ION | Authors: | Liu, Y, Gotte, G, Libonati, M, Eisenberg, D. | Deposit date: | 2001-08-15 | Release date: | 2002-03-13 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structures of the two 3D domain-swapped RNase A trimers. Protein Sci., 11, 2002
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