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PDB: 130 件
4OBC
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BU of 4obc by Molmil
Crystal structure of HCV polymerase NS5b genotype 2a JFH-1 isolate with the S15G, C223H, V321I resistance mutations against the guanosine analog GS-0938 (PSI-3529238)
分子名称: 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ...
著者Edwards, T.E, Abendroth, J, Appleby, T.C.
登録日2014-01-07
公開日2014-09-10
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Molecular and Structural Basis for the Roles of Hepatitis C Virus Polymerase NS5B Amino Acids 15, 223, and 321 in Viral Replication and Drug Resistance.
Antimicrob.Agents Chemother., 58, 2014
4OGX
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BU of 4ogx by Molmil
Crystal structure of Fab DX-2930 in complex with human plasma kallikrein at 2.4 Angstrom resolution
分子名称: DX-2930 HEAVY CHAIN, DX-2930 LIGHT CHAIN, Plasma kallikrein, ...
著者Edwards, T.E, Clifton, M.C, Abendroth, J, Nixon, A, Ladner, R.
登録日2014-01-16
公開日2014-07-09
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Inhibition of plasma kallikrein by a highly specific active site blocking antibody.
J.Biol.Chem., 289, 2014
6UGK
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BU of 6ugk by Molmil
CRYSTAL STRUCTURE OF CIRCULARLY PERMUTED HUMAN TASPASE-1
分子名称: CHLORIDE ION, SODIUM ION, Threonine aspartase 1,Threonine aspartase 1
著者Edwards, T.E, Delker, S.L.
登録日2019-09-26
公開日2021-03-10
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural insights into the function of the catalytically active human Taspase1.
Structure, 29, 2021
4OGY
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BU of 4ogy by Molmil
Crystal structure of Fab DX-2930 in complex with human plasma kallikrein at 2.1 Angstrom resolution
分子名称: 1,2-ETHANEDIOL, DX-2930 HEAVY CHAIN, DX-2930 LIGHT CHAIN, ...
著者Edwards, T.E, Clifton, M.C, Abendroth, J, Nixon, A, Ladner, R.
登録日2014-01-16
公開日2014-07-09
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Inhibition of plasma kallikrein by a highly specific active site blocking antibody.
J.Biol.Chem., 289, 2014
2HOK
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BU of 2hok by Molmil
Crystal structure of an E. coli thi-box riboswitch bound to thiamine pyrophosphate, calcium ions
分子名称: CALCIUM ION, THIAMINE DIPHOSPHATE, thi-box riboswitch
著者Edwards, T.E, Ferre-D'Amare, A.R.
登録日2006-07-14
公開日2006-09-19
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Crystal Structures of the Thi-Box Riboswitch Bound to Thiamine Pyrophosphate Analogs Reveal Adaptive RNA-Small Molecule Recognition
Structure, 14, 2006
2HOM
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BU of 2hom by Molmil
Crystal structure of an E. coli thi-box riboswitch bound to thiamine monophosphate
分子名称: CALCIUM ION, MAGNESIUM ION, THIAMIN PHOSPHATE, ...
著者Edwards, T.E, Ferre-D'Amare, A.R.
登録日2006-07-14
公開日2006-09-19
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献Crystal Structures of the Thi-Box Riboswitch Bound to Thiamine Pyrophosphate Analogs Reveal Adaptive RNA-Small Molecule Recognition
Structure, 14, 2006
2HOL
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BU of 2hol by Molmil
Crystal structure of an E. coli thi-box riboswitch bound to thiamine pyrophosphate, barium ions
分子名称: BARIUM ION, CALCIUM ION, MAGNESIUM ION, ...
著者Edwards, T.E, Ferre-D'Amare, A.R.
登録日2006-07-14
公開日2006-09-19
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal Structures of the Thi-Box Riboswitch Bound to Thiamine Pyrophosphate Analogs Reveal Adaptive RNA-Small Molecule Recognition
Structure, 14, 2006
2HOJ
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BU of 2hoj by Molmil
Crystal structure of an E. coli thi-box riboswitch bound to thiamine pyrophosphate, manganese ions
分子名称: MAGNESIUM ION, MANGANESE (II) ION, THIAMINE DIPHOSPHATE, ...
著者Edwards, T.E, Ferre-D'Amare, A.R.
登録日2006-07-14
公開日2006-09-19
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structures of the Thi-Box Riboswitch Bound to Thiamine Pyrophosphate Analogs Reveal Adaptive RNA-Small Molecule Recognition
Structure, 14, 2006
2HOP
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BU of 2hop by Molmil
Crystal structure of an E. coli thi-box riboswitch bound to pyrithiamine
分子名称: 1-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-3-(2-HYDROXYETHYL)-2-METHYLPYRIDINIUM, CALCIUM ION, MAGNESIUM ION, ...
著者Edwards, T.E, Ferre-D'Amare, A.R.
登録日2006-07-14
公開日2006-09-19
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Crystal Structures of the Thi-Box Riboswitch Bound to Thiamine Pyrophosphate Analogs Reveal Adaptive RNA-Small Molecule Recognition
Structure, 14, 2006
2HOO
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BU of 2hoo by Molmil
Crystal structure of an E. coli thi-box riboswitch bound to benfotiamine
分子名称: CALCIUM ION, S-BENZOYLTHIAMINE O-MONOPHOSPHATE, thi-box riboswitch
著者Edwards, T.E, Ferre-D'Amare, A.R.
登録日2006-07-14
公開日2006-09-19
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal Structures of the Thi-Box Riboswitch Bound to Thiamine Pyrophosphate Analogs Reveal Adaptive RNA-Small Molecule Recognition
Structure, 14, 2006
4E7A
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BU of 4e7a by Molmil
Crystal structure of a product state assembly of HCV NS5B genotype 2a JFH-1 isolate with beta hairpin deletion bound to primer-template RNA with a 2',3'-ddC
分子名称: 5'-R(*CP*AP*UP*GP*GP*C)-D(P*(DOC))-3', RNA-directed RNA polymerase
著者Edwards, T.E, Mosley, R.T.
登録日2012-03-16
公開日2012-04-18
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure of hepatitis C virus polymerase in complex with primer-template RNA.
J.Virol., 86, 2012
4E76
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BU of 4e76 by Molmil
Apo crystal structure of HCV NS5B genotype 2A JFH-1 isolate with beta hairpin loop deletion
分子名称: 1,2-ETHANEDIOL, RNA-directed RNA polymerase, SULFATE ION
著者Edwards, T.E, Mosley, R.T.
登録日2012-03-16
公開日2012-04-18
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of hepatitis C virus polymerase in complex with primer-template RNA.
J.Virol., 86, 2012
4E78
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BU of 4e78 by Molmil
Crystal structure of a product state assembly of HCV NS5B genotype 2a JFH-1 isolate with beta hairpin loop deletion bound to primer-template RNA with 3'-dG
分子名称: 5'-R(*U*AP*CP*CP*GP*(GDO))-3', PROTEIN (RNA-directed RNA polymerase)
著者Edwards, T.E, Mosley, R.T.
登録日2012-03-16
公開日2012-04-18
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure of hepatitis C virus polymerase in complex with primer-template RNA.
J.Virol., 86, 2012
4EYE
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BU of 4eye by Molmil
Crystal structure of a probable oxidoreductase from Mycobacterium abscessus solved by iodide ion SAD
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, IODIDE ION, Probable oxidoreductase
著者Edwards, T.E, Abendroth, J, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2012-05-01
公開日2012-05-09
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Increasing the structural coverage of tuberculosis drug targets.
Tuberculosis (Edinb), 95, 2015
3TE8
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BU of 3te8 by Molmil
Crystal structure of risS periplasmic domain at low pH dimer with N-termini ordered
分子名称: Sensor histidine kinase RisS
著者Edwards, T.E, Abendroth, J, Labiuk, S.L, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2011-08-12
公開日2011-08-24
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structure of risS periplasmic domain at low pH dimer with N-termini ordered
To be Published
5WHJ
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BU of 5whj by Molmil
Crystal structure of Fab fragment of anti-FcRn antibody DX-2507
分子名称: DX-2507 Fab heavy chain, DX-2507 Fab light chain
著者Edwards, T.E, Fairman, J.W, Nixon, A.E, Kenniston, J.A.
登録日2017-07-17
公開日2017-09-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural basis for pH-insensitive inhibition of immunoglobulin G recycling by an anti-neonatal Fc receptor antibody.
J. Biol. Chem., 292, 2017
5WHK
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BU of 5whk by Molmil
Crystal structure of Fab fragment of antibody DX-2507 bound to FcRn-B2M
分子名称: 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Beta-2-microglobulin, ...
著者Edwards, T.E, Clifton, M.C, Nixon, A.E, Kenniston, J.A.
登録日2017-07-17
公開日2017-09-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis for pH-insensitive inhibition of immunoglobulin G recycling by an anti-neonatal Fc receptor antibody.
J. Biol. Chem., 292, 2017
4WTD
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BU of 4wtd by Molmil
CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH ADP, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-AUAAAUUU
分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, MANGANESE (II) ION, ...
著者Edwards, T.E, Fox III, D, Appleby, T.C.
登録日2014-10-29
公開日2015-02-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
4WTF
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BU of 4wtf by Molmil
CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH GS-639475, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-CAAAAUUU
分子名称: 2'-C-methyluridine 5'-(trihydrogen diphosphate), CHLORIDE ION, MANGANESE (II) ION, ...
著者Edwards, T.E, Appleby, T.C, Mcgrath, M.E.
登録日2014-10-30
公開日2015-02-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
4WTJ
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BU of 4wtj by Molmil
CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS IN COMPLEX WITH RNA TEMPLATE 5'-AUCC, RNA PRIMER 5'-PGG, MN2+, AND ADP
分子名称: 1,2-ETHANEDIOL, 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
著者Edwards, T.E, Appleby, T.C.
登録日2014-10-30
公開日2015-02-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
4WTM
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BU of 4wtm by Molmil
CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS IN COMPLEX WITH RNA TEMPLATE 5'-UAGG, RNA PRIMER 5'-PCC, MN2+, AND UDP
分子名称: CHLORIDE ION, MANGANESE (II) ION, RNA PRIMER CC, ...
著者Edwards, T.E, Appleby, T.C, Fox III, D.
登録日2014-10-30
公開日2015-02-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
4WT9
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BU of 4wt9 by Molmil
APO CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH E86Q E87Q S15G C223H V321I AND DELTA8 MUTATIONS
分子名称: 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ...
著者Edwards, T.E, Appleby, T.C.
登録日2014-10-29
公開日2015-02-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
4WTA
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BU of 4wta by Molmil
CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH UDP, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-CAAAAUUU
分子名称: CHLORIDE ION, MANGANESE (II) ION, RNA PRIMER TEMPLATE CAAAAUUU, ...
著者Edwards, T.E, Appleby, T.C.
登録日2014-10-29
公開日2015-02-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
4WTC
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BU of 4wtc by Molmil
CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH CDP, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-AGAAAUUU
分子名称: CHLORIDE ION, CYTIDINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ...
著者Edwards, T.E, Appleby, T.C.
登録日2014-10-29
公開日2015-02-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015
4WTE
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BU of 4wte by Molmil
CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH GDP, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-ACAAAUUU
分子名称: CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ...
著者Edwards, T.E, Appleby, T.C.
登録日2014-10-29
公開日2015-02-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural basis for RNA replication by the hepatitis C virus polymerase.
Science, 347, 2015

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