5CRJ
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![BU of 5crj by Molmil](/molmil-images/mine/5crj) | Crystal Structure of the MTERF1 F322A substitution bound to the termination sequence. | Descriptor: | DNA (5'-D(*AP*TP*TP*AP*CP*CP*GP*GP*GP*CP*TP*CP*TP*GP*CP*CP*AP*TP*CP*TP*TP*A)-3'), DNA (5'-D(*TP*AP*AP*GP*AP*TP*GP*GP*CP*AP*GP*AP*GP*CP*CP*CP*GP*GP*TP*AP*AP*T)-3'), Transcription termination factor 1, ... | Authors: | Byrnes, J, Hauser, K, Norona, L, Mejia, E, Simmerling, C, Garcia-Diaz, M. | Deposit date: | 2015-07-23 | Release date: | 2015-11-25 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Base Flipping by MTERF1 Can Accommodate Multiple Conformations and Occurs in a Stepwise Fashion. J.Mol.Biol., 428, 2016
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8HQZ
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![BU of 8hqz by Molmil](/molmil-images/mine/8hqz) | Baseplate of DT57C bacteriophage in the full state | Descriptor: | Baseplate hub protein, Distal tail protein, L-shaped tail fiber assembly, ... | Authors: | Ayala, R, Moiseenko, A.V, Chen, T.H, Kulikov, E.E, Golomidova, A.K, Orekhov, P.S, Street, M.A, Sokolova, O.S, Letarov, A.V, Wolf, M. | Deposit date: | 2022-12-14 | Release date: | 2023-12-13 | Last modified: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Nearly complete structure of bacteriophage DT57C reveals architecture of head-to-tail interface and lateral tail fibers. Nat Commun, 14, 2023
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6MZL
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![BU of 6mzl by Molmil](/molmil-images/mine/6mzl) | Human TFIID canonical state | Descriptor: | TATA-box-binding protein, Transcription initiation factor TFIID subunit 1, Transcription initiation factor TFIID subunit 10, ... | Authors: | Patel, A.B, Louder, R.K, Greber, B.J, Grunberg, S, Luo, J, Fang, J, Liu, Y, Ranish, J, Hahn, S, Nogales, E. | Deposit date: | 2018-11-05 | Release date: | 2018-11-28 | Last modified: | 2019-11-20 | Method: | ELECTRON MICROSCOPY (23 Å) | Cite: | Structure of human TFIID and mechanism of TBP loading onto promoter DNA. Science, 362, 2018
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6VGN
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![BU of 6vgn by Molmil](/molmil-images/mine/6vgn) | ClpP1P2 complex from M. tuberculosis bound to ADEP | Descriptor: | ATP-dependent Clp protease proteolytic subunit, ATP-dependent Clp protease proteolytic subunit 1, R0M-WFP-ALO-PRO-YCP-ALA-MP8 | Authors: | Ripstein, Z.A, Vahidi, S, Rubinstein, J.L, Kay, L.E. | Deposit date: | 2020-01-08 | Release date: | 2020-03-18 | Last modified: | 2020-04-01 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | An allosteric switch regulatesMycobacterium tuberculosisClpP1P2 protease function as established by cryo-EM and methyl-TROSY NMR. Proc.Natl.Acad.Sci.USA, 117, 2020
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8HQO
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![BU of 8hqo by Molmil](/molmil-images/mine/8hqo) | Neck of DT57C bacteriophage in the full state | Descriptor: | Head completion protein, Portal protein, Tail terminator protein, ... | Authors: | Ayala, R, Moiseenko, A.V, Chen, T.H, Kulikov, E.E, Golomidova, A.K, Orekhov, P.S, Street, M.A, Sokolova, O.S, Letarov, A.V, Wolf, M. | Deposit date: | 2022-12-13 | Release date: | 2023-12-13 | Last modified: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Nearly complete structure of bacteriophage DT57C reveals architecture of head-to-tail interface and lateral tail fibers. Nat Commun, 14, 2023
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6N0K
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![BU of 6n0k by Molmil](/molmil-images/mine/6n0k) | The complex of CCG-257081 bound to pirin | Descriptor: | (3R)-N-(4-chlorophenyl)-5,5-difluoro-1-[3-fluoro-5-(pyridin-4-yl)benzene-1-carbonyl]piperidine-3-carboxamide, 1,2-ETHANEDIOL, FE (III) ION, ... | Authors: | Lisabeth, E.M, Jin, X, Neubig, R. | Deposit date: | 2018-11-07 | Release date: | 2019-07-10 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.46 Å) | Cite: | Identification of Pirin as a Molecular Target of the CCG-1423/CCG-203971 Series of Antifibrotic and Antimetastatic Compounds ACS Pharmacol Transl Sci, 2, 2019
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6N7J
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![BU of 6n7j by Molmil](/molmil-images/mine/6n7j) | |
7QK0
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![BU of 7qk0 by Molmil](/molmil-images/mine/7qk0) | Crystal structure of human BCL6 BTB domain in complex with compound 12a | Descriptor: | (2~{S})-10-[[5-chloranyl-2-[(3~{S},5~{R})-3-methyl-5-oxidanyl-piperidin-1-yl]pyrimidin-4-yl]amino]-2-cyclopropyl-3,3-bis(fluoranyl)-7-methyl-2,4-dihydro-1~{H}-[1,4]oxazepino[2,3-c]quinolin-6-one, 1,2-ETHANEDIOL, B-cell lymphoma 6 protein, ... | Authors: | Gunnell, E.A, Le Bihan, Y.-V, van Montfort, R.L.M. | Deposit date: | 2021-12-17 | Release date: | 2022-06-15 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo . J.Med.Chem., 65, 2022
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8CYE
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![BU of 8cye by Molmil](/molmil-images/mine/8cye) | |
4YUH
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![BU of 4yuh by Molmil](/molmil-images/mine/4yuh) | Multiconformer synchrotron model of CypA at 150 K | Descriptor: | Peptidyl-prolyl cis-trans isomerase A | Authors: | Keedy, D.A, Kenner, L.R, Warkentin, M, Woldeyes, R.A, Thompson, M.C, Brewster, A.S, Van Benschoten, A.H, Baxter, E.L, Hopkins, J.B, Uervirojnangkoorn, M, McPhillips, S.E, Song, J, Mori, R.A, Holton, J.M, Weis, W.I, Brunger, A.T, Soltis, M, Lemke, H, Gonzalez, A, Sauter, N.K, Cohen, A.E, van den Bedem, H, Thorne, R.E, Fraser, J.S. | Deposit date: | 2015-03-18 | Release date: | 2015-10-14 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.34 Å) | Cite: | Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography. Elife, 4, 2015
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6UVG
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![BU of 6uvg by Molmil](/molmil-images/mine/6uvg) | Crystal structure of BCL-XL bound to compound 13: (R)-2-(3-([1,1'-Biphenyl]-4-carbonyl)-3-(4-methylbenzyl)ureido)-3-(((3R,5R,7R)-adamantan-1-ylmethyl)sulfonyl)propanoic acid | Descriptor: | (R)-2-(3-([1,1'-Biphenyl]-4-carbonyl)-3-(4-methylbenzyl)ureido)-3-(((3R,5R,7R)-adamantan-1-ylmethyl)sulfonyl)propanoic acid, 1,2-ETHANEDIOL, Bcl-2-like protein 1, ... | Authors: | Roy, M.J, Lessene, G, Czabotar, P.E. | Deposit date: | 2019-11-02 | Release date: | 2021-05-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure-Guided Development of Potent Benzoylurea Inhibitors of BCL-X L and BCL-2. J.Med.Chem., 64, 2021
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6NEM
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![BU of 6nem by Molmil](/molmil-images/mine/6nem) | |
8FB4
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![BU of 8fb4 by Molmil](/molmil-images/mine/8fb4) | Structure of an alternating AT 16-mer bound by diamidine DB1476: 5'-GCTGGATATATCCAGC-3 | Descriptor: | 4,4'-(1H-benzimidazole-2,6-diyl)di(benzene-1-carboximidamide), CALCIUM ION, DNA (5'-D(*GP*CP*TP*GP*GP*AP*TP*AP*TP*AP*TP*CP*CP*AP*GP*C)-3') | Authors: | Terrell, J.R, Ogbonna, E.N, Wilson, W.D. | Deposit date: | 2022-11-29 | Release date: | 2023-02-22 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | X-ray Structure Characterization of the Selective Recognition of AT Base Pair Sequences. Acs Bio Med Chem Au, 3, 2023
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6WQY
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![BU of 6wqy by Molmil](/molmil-images/mine/6wqy) | GH5-4 broad specificity endoglucanase from Bacteroides salanitronis | Descriptor: | CHLORIDE ION, Cellulase, MAGNESIUM ION | Authors: | Bingman, C.A, Smith, R.W, Glasgow, E.M, Fox, B.G. | Deposit date: | 2020-04-29 | Release date: | 2020-11-18 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | A structural and kinetic survey of GH5_4 endoglucanases reveals determinants of broad substrate specificity and opportunities for biomass hydrolysis. J.Biol.Chem., 295, 2020
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4YSJ
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![BU of 4ysj by Molmil](/molmil-images/mine/4ysj) | |
4Y5V
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![BU of 4y5v by Molmil](/molmil-images/mine/4y5v) | Diabody 305 complex with EpoR | Descriptor: | DI(HYDROXYETHYL)ETHER, Diabody 305 VL domain, Erythropoietin receptor, ... | Authors: | Moraga, I, Guo, F, Ozkan, E, Jude, K.M, Garcia, K.C. | Deposit date: | 2015-02-12 | Release date: | 2015-04-29 | Method: | X-RAY DIFFRACTION (2.604 Å) | Cite: | Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands. Cell, 160, 2015
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4YUO
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![BU of 4yuo by Molmil](/molmil-images/mine/4yuo) | High-resolution multiconformer synchrotron model of CypA at 273 K | Descriptor: | Peptidyl-prolyl cis-trans isomerase A | Authors: | Keedy, D.A, Kenner, L.R, Warkentin, M, Woldeyes, R.A, Thompson, M.C, Brewster, A.S, Van Benschoten, A.H, Baxter, E.L, Hopkins, J.B, Uervirojnangkoorn, M, McPhillips, S.E, Song, J, Mori, R.A, Holton, J.M, Weis, W.I, Brunger, A.T, Soltis, M, Lemke, H, Gonzalez, A, Sauter, N.K, Cohen, A.E, van den Bedem, H, Thorne, R.E, Fraser, J.S. | Deposit date: | 2015-03-18 | Release date: | 2015-05-20 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography. Elife, 4, 2015
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7QYR
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![BU of 7qyr by Molmil](/molmil-images/mine/7qyr) | Crystal structure of RimK from Pseudomonas aeruginosa PAO1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Probable alpha-L-glutamate ligase, poly-glutamate | Authors: | Thompson, C.M.A, Little, R.H, Stevenson, C.E.M, Lawson, D.M, Malone, J.G. | Deposit date: | 2022-01-29 | Release date: | 2022-10-05 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural insights into the mechanism of adaptive ribosomal modification by Pseudomonas RimK. Proteins, 91, 2023
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6WTZ
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![BU of 6wtz by Molmil](/molmil-images/mine/6wtz) | Cryo-EM structure of E. Coli OmpF | Descriptor: | Outer membrane porin F | Authors: | Morgan, C.E, Su, C.-C, Lyu, M, Yu, E.W. | Deposit date: | 2020-05-04 | Release date: | 2021-01-20 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | A 'Build and Retrieve' methodology to simultaneously solve cryo-EM structures of membrane proteins. Nat.Methods, 18, 2021
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7QYS
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![BU of 7qys by Molmil](/molmil-images/mine/7qys) | Crystal structure of RimK from Pseudomonas syringae DC3000 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Probable alpha-L-glutamate ligase | Authors: | Thompson, C.M.A, Little, R.H, Stevenson, C.E.M, Lawson, D.M, Malone, J.G. | Deposit date: | 2022-01-29 | Release date: | 2022-10-05 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural insights into the mechanism of adaptive ribosomal modification by Pseudomonas RimK. Proteins, 91, 2023
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5JBH
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![BU of 5jbh by Molmil](/molmil-images/mine/5jbh) | Cryo-EM structure of a full archaeal ribosomal translation initiation complex in the P-IN conformation | Descriptor: | 16S ribosomal RNA, 30S ribosomal protein SX, 30S ribosomal protein eL41, ... | Authors: | Coureux, P.-D, Schmitt, E, Mechulam, Y. | Deposit date: | 2016-04-13 | Release date: | 2016-12-07 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (5.34 Å) | Cite: | Cryo-EM study of start codon selection during archaeal translation initiation. Nat Commun, 7, 2016
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7SVJ
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![BU of 7svj by Molmil](/molmil-images/mine/7svj) | Bile Salt Hydrolase from Lactobacillus ingluviei | Descriptor: | CALCIUM ION, Choloylglycine hydrolase, DI(HYDROXYETHYL)ETHER, ... | Authors: | Walker, M.E, Patel, S, Redinbo, M.R. | Deposit date: | 2021-11-19 | Release date: | 2023-01-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.43 Å) | Cite: | Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut. Nat Microbiol, 8, 2023
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7SVI
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![BU of 7svi by Molmil](/molmil-images/mine/7svi) | |
7SVG
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![BU of 7svg by Molmil](/molmil-images/mine/7svg) | |
5JGW
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![BU of 5jgw by Molmil](/molmil-images/mine/5jgw) | Crystal structure of maize AKR4C13 in complex with NADP and acetate | Descriptor: | ACETATE ION, Aldose reductase, AKR4C13, ... | Authors: | Santos, M.L, Giuseppe, P.O, Kiyota, E, Sousa, S.M, Schmelz, E.A, Yunes, J.A, Koch, K.E, Murakami, M.T, Aparicio, R. | Deposit date: | 2016-04-20 | Release date: | 2017-05-03 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of maize AKR4C13 in complex with NADP and acetate To Be Published
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