6NEM
3-hydroxy-5-[(naphthalen-1-yl)methyl]-6-[4-(1H-tetrazol-5-yl)phenyl]pyridin-2(1H)-one bound to influenza 2009 pH1N1 endonuclease
Summary for 6NEM
Entry DOI | 10.2210/pdb6nem/pdb |
Related | 6NEL |
Descriptor | Polymerase acidic protein, MANGANESE (II) ION, 3-hydroxy-5-[(naphthalen-1-yl)methyl]-6-[4-(1H-tetrazol-5-yl)phenyl]pyridin-2(1H)-one, ... (5 entities in total) |
Functional Keywords | influenza endonuclease inhibitor chelator, viral protein, viral protein-inhibitor complex, viral protein/inhibitor |
Biological source | Influenza A virus (A/Luxembourg/43/2009(H1N1)) |
Total number of polymer chains | 1 |
Total formula weight | 29161.56 |
Authors | Bauman, J.D.,Arnold, E. (deposition date: 2018-12-17, release date: 2019-05-01, Last modification date: 2023-10-11) |
Primary citation | Sagong, H.Y.,Bauman, J.D.,Nogales, A.,Martinez-Sobrido, L.,Arnold, E.,LaVoie, E.J. Aryl and Arylalkyl Substituted 3-Hydroxypyridin-2(1H)-ones: Synthesis and Evaluation as Inhibitors of Influenza A Endonuclease. Chemmedchem, 14:1204-1223, 2019 Cited by PubMed: 30983160DOI: 10.1002/cmdc.201900084 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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