6NEL
4-(2-(4-fluorophenyl)-5-hydroxy-6-oxo-1,6-dihydropyridin-3-yl)benzoic acid bound to influenza 2009 pH1N1 endonuclease
Summary for 6NEL
Entry DOI | 10.2210/pdb6nel/pdb |
Descriptor | Polymerase acidic protein, MANGANESE (II) ION, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | influenza endonuclease inhibitor chelator, viral protein, viral protein-inhibitor complex, viral protein/inhibitor |
Biological source | Influenza A virus (A/Luxembourg/43/2009(H1N1)) |
Total number of polymer chains | 1 |
Total formula weight | 29060.81 |
Authors | Bauman, J.D.,Arnold, E. (deposition date: 2018-12-17, release date: 2019-05-01, Last modification date: 2023-10-11) |
Primary citation | Sagong, H.Y.,Bauman, J.D.,Nogales, A.,Martinez-Sobrido, L.,Arnold, E.,LaVoie, E.J. Aryl and Arylalkyl Substituted 3-Hydroxypyridin-2(1H)-ones: Synthesis and Evaluation as Inhibitors of Influenza A Endonuclease. Chemmedchem, 14:1204-1223, 2019 Cited by PubMed: 30983160DOI: 10.1002/cmdc.201900084 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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