8DD0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8dd0 by Molmil](/molmil-images/mine/8dd0) | |
1W98
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1w98 by Molmil](/molmil-images/mine/1w98) | The structural basis of CDK2 activation by cyclin E | 分子名称: | CELL DIVISION PROTEIN KINASE 2, G1/S-SPECIFIC CYCLIN E1 | 著者 | Lowe, E.D, Honda, R, Dubinina, E, Skamnaki, V, Cook, A, Johnson, L.N. | 登録日 | 2004-10-07 | 公開日 | 2005-02-02 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | The Structure of Cyclin E1/Cdk2: Implications for Cdk2 Activation and Cdk2-Independent Roles Embo J., 24, 2005
|
|
6NCU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ncu by Molmil](/molmil-images/mine/6ncu) | |
7U5E
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7u5e by Molmil](/molmil-images/mine/7u5e) | I-F3b Cascade-TniQ partial R-loop complex | 分子名称: | Cas6, Cas7, Cas8/5, ... | 著者 | Park, J.U, Mehrotra, E, Kellogg, E.H. | 登録日 | 2022-03-02 | 公開日 | 2023-06-14 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (4.03 Å) | 主引用文献 | Multiple adaptations underly co-option of a CRISPR surveillance complex for RNA-guided DNA transposition. Mol.Cell, 83, 2023
|
|
7U5D
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7u5d by Molmil](/molmil-images/mine/7u5d) | I-F3b Cascade-TniQ full R-loop complex | 分子名称: | Cas6, Cas7, Cas8/5, ... | 著者 | Park, J.U, Mehrotra, E, Kellogg, E.H. | 登録日 | 2022-03-02 | 公開日 | 2023-06-21 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | 主引用文献 | Multiple adaptations underly co-option of a CRISPR surveillance complex for RNA-guided DNA transposition. Mol.Cell, 83, 2023
|
|
4WO1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wo1 by Molmil](/molmil-images/mine/4wo1) | Crystal structure of the DAP12 transmembrane domain in lipid cubic phase | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CALCIUM ION, TYRO protein tyrosine kinase-binding protein | 著者 | Call, M.J, Call, M.E, Knoblich, K. | 登録日 | 2014-10-15 | 公開日 | 2015-06-03 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | Transmembrane Complexes of DAP12 Crystallized in Lipid Membranes Provide Insights into Control of Oligomerization in Immunoreceptor Assembly. Cell Rep, 11, 2015
|
|
6NOG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6nog by Molmil](/molmil-images/mine/6nog) | Poised-state Dot1L bound to the H2B-Ubiquitinated nucleosome | 分子名称: | 601 DNA Strand 1, 601 DNA Strand 2, Histone H2A type 1, ... | 著者 | Worden, E.J, Hoffmann, N.A, Wolberger, C. | 登録日 | 2019-01-16 | 公開日 | 2019-02-20 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L. Cell, 176, 2019
|
|
1VIE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1vie by Molmil](/molmil-images/mine/1vie) | |
6NP9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6np9 by Molmil](/molmil-images/mine/6np9) | PD-L1 IgV domain V76T with fragment | 分子名称: | Programmed cell death 1 ligand 1, SULFATE ION | 著者 | Zhao, B, Perry, E. | 登録日 | 2019-01-17 | 公開日 | 2019-02-20 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | 主引用文献 | Fragment-based screening of programmed death ligand 1 (PD-L1). Bioorg. Med. Chem. Lett., 29, 2019
|
|
1VIN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1vin by Molmil](/molmil-images/mine/1vin) | |
7BHS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7bhs by Molmil](/molmil-images/mine/7bhs) | Crystal structure of MAT2a with quinazoline fragment 2 bound in the allosteric site | 分子名称: | 6-chloranyl-2-methoxy-4-phenyl-quinazoline, S-ADENOSYLMETHIONINE, S-adenosylmethionine synthase isoform type-2 | 著者 | Schimpl, M, De Fusco, C, Borjesson, U, Cheung, T, Collie, I, Evans, L, Narasimhan, P, Stubbs, C, Vazquez-Chantada, M, Wagner, D.J, Grondine, M, Tentarelli, S, Underwood, E, Argyrou, A, Bagal, S, Chiarparin, E, Robb, G, Scott, J.S. | 登録日 | 2021-01-11 | 公開日 | 2021-04-21 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | 主引用文献 | Fragment-Based Design of a Potent MAT2a Inhibitor and in Vivo Evaluation in an MTAP Null Xenograft Model. J.Med.Chem., 64, 2021
|
|
5WJT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5wjt by Molmil](/molmil-images/mine/5wjt) | |
2MSF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2msf by Molmil](/molmil-images/mine/2msf) | NMR SOLUTION STRUCTURE OF SCORPION VENOM TOXIN Ts11 (TsPep1) FROM Tityus serrulatus | 分子名称: | Peptide TsPep1 | 著者 | Maiti, M, Lescrinier, E, Herdewijn, P, Cremonez, C.M, Peigneur, S, Cassoli, J.S, Dutra, A.A.A, Waelkens, E, Pimenta, A.M.C, De Lima, M.H, Tytgat, J, Arantes, E.C. | 登録日 | 2014-08-01 | 公開日 | 2015-08-26 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural and Functional Elucidation of Peptide Ts11 Shows Evidence of a Novel Subfamily of Scorpion Venom Toxins. Toxins (Basel), 8, 2016
|
|
6NJ9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6nj9 by Molmil](/molmil-images/mine/6nj9) | Active state Dot1L bound to the H2B-Ubiquitinated nucleosome, 2-to-1 complex | 分子名称: | 601 DNA Strand 1, 601 DNA Strand 2, Histone H2A type 1, ... | 著者 | Worden, E.J, Hoffmann, N.A, Wolberger, C. | 登録日 | 2019-01-02 | 公開日 | 2019-02-20 | 最終更新日 | 2021-06-16 | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | 主引用文献 | Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L. Cell, 176, 2019
|
|
1VYZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1vyz by Molmil](/molmil-images/mine/1vyz) | Structure of CDK2 complexed with PNU-181227 | 分子名称: | CELL DIVISION PROTEIN KINASE 2, N-(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)BENZAMIDE | 著者 | Pevarello, P, Brasca, M.G, Amici, R, Orsini, P, Traquandi, G, Corti, L, Piutti, C, Sansonna, P, Villa, M, Pierce, B.S, Pulici, M, Giordano, G, Martina, K, Lfritzen, E, Nugent, R.A, Casale, E, Cameron, A, Ciomei, M, Roletto, F, Isacchi, A, Fogliatto, G, Pesenti, E, Pastori, W, Marsiglio, W, Leach, K.L, Clare, P.M, Fiorentini, F, Varasi, M, Vulpetti, A, Warpehoski, M.A. | 登録日 | 2004-05-07 | 公開日 | 2004-06-17 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | 3-Aminopyrazole Inhibitors of Cdk2/Cyclin a as Antitumor Agents. 1. Lead Finding J.Med.Chem., 47, 2004
|
|
6ZNL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6znl by Molmil](/molmil-images/mine/6znl) | Cryo-EM structure of the dynactin complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ARP1 actin related protein 1 homolog A, ... | 著者 | Lau, C.K, Lacey, S.E, Carter, A.P. | 登録日 | 2020-07-06 | 公開日 | 2020-07-29 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Cryo-EM reveals the complex architecture of dynactin's shoulder region and pointed end. Embo J., 40, 2021
|
|
7Q4M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7q4m by Molmil](/molmil-images/mine/7q4m) | Type II beta-amyloid 42 Filaments from Human Brain | 分子名称: | Amyloid-beta precursor protein, UNKNOWN ATOM OR ION | 著者 | Yang, Y, Arseni, D, Zhang, W, Huang, M, Lovestam, S.K.A, Schweighauser, M, Kotecha, A, Murzin, A.G, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Garringer, H.J, Gelpi, E, Newell, K.L, Kovacs, G.G, Vidal, R, Ghetti, B, Falcon, B, Scheres, S.H.W, Goedert, M. | 登録日 | 2021-11-01 | 公開日 | 2021-11-24 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Cryo-EM structures of amyloid-beta 42 filaments from human brains. Science, 375, 2022
|
|
7AKK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7akk by Molmil](/molmil-images/mine/7akk) | Structure of a complement factor-receptor complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 beta chain, Complement C3b alpha' chain, ... | 著者 | Fernandez, F.J, Santos-Lopez, J, Martinez-Barricarte, R, Querol-Garcia, J, Navas-Yuste, S, Savko, M, Shepard, W.E, Rodriguez de Cordoba, S, Vega, M.C. | 登録日 | 2020-10-01 | 公開日 | 2022-04-13 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.395 Å) | 主引用文献 | The crystal structure of iC3b-CR3 alpha I reveals a modular recognition of the main opsonin iC3b by the CR3 integrin receptor Nat Commun, 13, 2022
|
|
3J05
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3j05 by Molmil](/molmil-images/mine/3j05) | Three-dimensional structure of Dengue virus serotype 1 complexed with HMAb 14c10 Fab | 分子名称: | envelope protein | 著者 | Teoh, E.P, Kukkaro, P, Teo, E.W, Lim, A, Tan, T.T, Shi, P.Y, Yip, A, Schul, W, Leo, Y.S, Chan, S.H, Smith, K.G.C, Ooi, E.E, Kemeny, D.M, Ng, G, Ng, M.L, Alonso, S, Fisher, D, Hanson, B, Lok, S.M, MacAry, P.A. | 登録日 | 2011-04-01 | 公開日 | 2012-07-04 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (7 Å) | 主引用文献 | The structural basis for serotype-specific neutralization of dengue virus by a human antibody. Sci Transl Med, 4, 2012
|
|
7Q4B
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7q4b by Molmil](/molmil-images/mine/7q4b) | Type I beta-amyloid 42 Filaments from Human Brain | 分子名称: | Amyloid-beta precursor protein, UNKNOWN ATOM OR ION | 著者 | Yang, Y, Arseni, D, Zhang, W, Huang, M, Lovestam, S.K.A, Schweighauser, M, Kotecha, A, Murzin, A.G, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Garringer, H.J, Gelpi, E, Newell, K.L, Kovacs, G.G, Vidal, R, Ghetti, B, Falcon, B, Scheres, S.H.W, Goedert, M. | 登録日 | 2021-10-30 | 公開日 | 2021-11-24 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Cryo-EM structures of amyloid-beta 42 filaments from human brains. Science, 375, 2022
|
|
6NY2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ny2 by Molmil](/molmil-images/mine/6ny2) | CasX-gRNA-DNA(45bp) state I | 分子名称: | CasX, DNA Non-target strand, DNA target strand, ... | 著者 | Liu, J.J, Orlova, N, Nogales, E, Doudna, J.A. | 登録日 | 2019-02-10 | 公開日 | 2019-02-27 | 最終更新日 | 2019-12-25 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | CasX enzymes comprise a distinct family of RNA-guided genome editors. Nature, 566, 2019
|
|
7OQZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7oqz by Molmil](/molmil-images/mine/7oqz) | Cryo-EM structure of human TMEM45A | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Transmembrane protein 45A | 著者 | Grieben, M, Pike, A.C.W, Evans, A, Shrestha, L, Venkaya, S, Mukhopadhyay, S.M.M, Moreira, T, Chalk, R, MacLean, E.M, Marsden, B.D, Burgess-Brown, N.A, Bountra, C, Carpenter, E.P. | 登録日 | 2021-06-04 | 公開日 | 2021-06-16 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | 主引用文献 | CryoEM structure of human TMEM45A To Be Published
|
|
3G2H
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3g2h by Molmil](/molmil-images/mine/3g2h) | Crystal structure of 1-(beta-D-glucopyranosyl)-4-substituted-1,2,3-triazoles in complex with glycogen phosphorylase | 分子名称: | 1-beta-D-glucopyranosyl-4-phenyl-1H-1,2,3-triazole, DIMETHYL SULFOXIDE, Glycogen phosphorylase, ... | 著者 | Chrysina, E.D, Bokor, E, Alexacou, K.-M, Charavgi, M.-D, Oikonomakos, G.N, Zographos, S.E, Leonidas, D.D, Oikonomakos, N.G, Somsak, L. | 登録日 | 2009-01-31 | 公開日 | 2010-02-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Amide-1,2,3-triazole bioisosterism: the glycogen phosphorylase case Tetrahedron: Asymmetry, 20, 2009
|
|
7UAV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7uav by Molmil](/molmil-images/mine/7uav) | Structure of Clostridium botulinum prophage Tad1 in apo state | 分子名称: | ABC transporter ATPase | 著者 | Lu, A, Leavitt, A, Yirmiya, E, Amitai, G, Garb, J, Morehouse, B.R, Hobbs, S.J, Sorek, R, Kranzusch, P.J. | 登録日 | 2022-03-14 | 公開日 | 2022-10-05 | 最終更新日 | 2022-11-23 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Viruses inhibit TIR gcADPR signalling to overcome bacterial defence. Nature, 611, 2022
|
|
7U32
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7u32 by Molmil](/molmil-images/mine/7u32) | MVV cleaved synaptic complex (CSC) intasome at 3.4 A resolution | 分子名称: | CALCIUM ION, DNA EV272, DNA EV273, ... | 著者 | Shan, Z, Pye, V.E, Cherepanov, P, Lyumkis, D. | 登録日 | 2022-02-25 | 公開日 | 2022-05-11 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.46 Å) | 主引用文献 | Multivalent interactions essential for lentiviral integrase function. Nat Commun, 13, 2022
|
|