8QZ3
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![BU of 8qz3 by Molmil](/molmil-images/mine/8qz3) | Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with an activatory nanobody (Nb67) | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Nanobody 67, POTASSIUM ION, ... | 著者 | Baronina, A, Pike, A.C.W, Rodstrom, K.E.J, Ang, J, Bushell, S.R, Chalk, R, Mukhopadhyay, S.M.M, Pardon, E, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N.A, Tucker, S.J, Steyaert, J, Carpenter, E.P, Structural Genomics Consortium (SGC) | 登録日 | 2023-10-26 | 公開日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation. Nat Commun, 15, 2024
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6QZ2
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![BU of 6qz2 by Molmil](/molmil-images/mine/6qz2) | Structure of MHETase from Ideonella sakaiensis | 分子名称: | CALCIUM ION, Mono(2-hydroxyethyl) terephthalate hydrolase | 著者 | Allen, M.D, Johnson, C.W, Knott, B.C, Beckham, G.T, McGeehan, J.E. | 登録日 | 2019-03-10 | 公開日 | 2020-09-30 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Characterization and engineering of a two-enzyme system for plastics depolymerization. Proc.Natl.Acad.Sci.USA, 117, 2020
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7ABU
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![BU of 7abu by Molmil](/molmil-images/mine/7abu) | Structure of SARS-CoV-2 Main Protease bound to RS102895 | 分子名称: | 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1~{H}-3,1-benzoxazine-4,4'-piperidine]-2-one, 3C-like proteinase, DIMETHYL SULFOXIDE, ... | 著者 | Guenther, S, Reinke, P.Y.A, Oberthuer, D, Yefanov, O, Gelisio, L, Ginn, H, Lieske, J, Domaracky, M, Brehm, W, Rahmani Mashour, A, White, T.A, Knoska, J, Pena Esperanza, G, Koua, F, Tolstikova, A, Groessler, M, Fischer, P, Hennicke, V, Fleckenstein, H, Trost, F, Galchenkova, M, Gevorkov, Y, Li, C, Awel, S, Paulraj, L.X, Ullah, N, Falke, S, Alves Franca, B, Schwinzer, M, Brognaro, H, Werner, N, Perbandt, M, Tidow, H, Seychell, B, Beck, T, Meier, S, Doyle, J.J, Giseler, H, Melo, D, Lane, T.J, Dunkel, I, Peck, A, Saouane, S, Hakanpaeae, J, Meyer, J, Noei, H, Gribbon, P, Ellinger, B, Kuzikov, M, Wolf, M, Zhang, L, Ehrt, C, Pletzer-Zelgert, J, Wollenhaupt, J, Feiler, C, Weiss, M, Schulz, E.C, Mehrabi, P, Norton-Baker, B, Schmidt, C, Lorenzen, K, Schubert, R, Han, H, Chari, A, Fernandez Garcia, Y, Turk, D, Hilgenfeld, R, Rarey, M, Zaliani, A, Chapman, H.N, Pearson, A, Betzel, C, Meents, A. | 登録日 | 2020-09-08 | 公開日 | 2020-12-02 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease. Science, 372, 2021
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4YO3
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![BU of 4yo3 by Molmil](/molmil-images/mine/4yo3) | Enteroaggregative Escherichia Coli TssA N-terminal fragment | 分子名称: | TssA | 著者 | Durand, E, Zoued, A, Spinelli, S, Douzi, B, Brunet, Y.R, Bebeacua, C, Legrand, P, Journet, L, Mignot, T, Cambillau, C, Cascales, E. | 登録日 | 2015-03-11 | 公開日 | 2016-02-17 | 最終更新日 | 2017-08-30 | 実験手法 | X-RAY DIFFRACTION (3.37 Å) | 主引用文献 | Priming and polymerization of a bacterial contractile tail structure. Nature, 531, 2016
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8U5L
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6UXO
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![BU of 6uxo by Molmil](/molmil-images/mine/6uxo) | Crystal structure of BAK core domain BH3-groove-dimer in complex with DDM | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Bcl-2 homologous antagonist/killer, ... | 著者 | Cowan, A.D, Colman, P.M, Czabotar, P.E. | 登録日 | 2019-11-07 | 公開日 | 2020-09-02 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.799 Å) | 主引用文献 | BAK core dimers bind lipids and can be bridged by them. Nat.Struct.Mol.Biol., 27, 2020
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5NJ9
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![BU of 5nj9 by Molmil](/molmil-images/mine/5nj9) | E. coli Microcin-processing metalloprotease TldD/E with DRVY angiotensin fragment bound | 分子名称: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ASP-ARG-VAL-TYR, ... | 著者 | Ghilarov, D, Serebryakova, M, Stevenson, C.E.M, Hearnshaw, S.J, Volkov, D, Maxwell, A, Lawson, D.M, Severinov, K. | 登録日 | 2017-03-28 | 公開日 | 2017-10-04 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | The Origins of Specificity in the Microcin-Processing Protease TldD/E. Structure, 25, 2017
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6MYQ
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![BU of 6myq by Molmil](/molmil-images/mine/6myq) | Avian mitochondrial complex II with ferulenol bound | 分子名称: | (~{Z})-2-oxidanylbut-2-enedioic acid, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 4-oxidanyl-3-[(2~{E},6~{E})-3,7,11-trimethyldodeca-2,6,10-trienyl]chromen-2-one, ... | 著者 | Berry, E.A, Huang, L.-S. | 登録日 | 2018-11-02 | 公開日 | 2019-11-06 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Crystallographic investigation of the ubiquinone binding site of respiratory Complex II and its inhibitors. Biochim Biophys Acta Proteins Proteom, 1869, 2021
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5FUR
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![BU of 5fur by Molmil](/molmil-images/mine/5fur) | Structure of human TFIID-IIA bound to core promoter DNA | 分子名称: | SUPER CORE PROMOTER, TATA-BOX-BINDING PROTEIN, TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1, ... | 著者 | Louder, R.K, He, Y, Lopez-Blanco, J.R, Fang, J, Chacon, P, Nogales, E. | 登録日 | 2016-01-29 | 公開日 | 2016-04-06 | 最終更新日 | 2017-08-02 | 実験手法 | ELECTRON MICROSCOPY (8.5 Å) | 主引用文献 | Structure of Promoter-Bound TFIID and Model of Human Pre-Initiation Complex Assembly. Nature, 531, 2016
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5L8M
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![BU of 5l8m by Molmil](/molmil-images/mine/5l8m) | Wild-type PAS-GAF fragment from Deinococcus radiodurans Bphp collected at LCLS | 分子名称: | 3-[2-[(Z)-[3-(2-carboxyethyl)-5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium -2-ylidene]methyl]-5-[(Z)-[(3E)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1H-pyrrol-3- yl]propanoic acid, ACETATE ION, Bacteriophytochrome | 著者 | Claesson, E, Takala, H, Edlund, P, Henry, L, Dods, R, Schmidt, M, Westenhoff, S. | 登録日 | 2016-06-08 | 公開日 | 2016-10-26 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The room temperature crystal structure of a bacterial phytochrome determined by serial femtosecond crystallography. Sci Rep, 6, 2016
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7P59
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![BU of 7p59 by Molmil](/molmil-images/mine/7p59) | Variant Surface Glycoprotein 3 (VSG3, MiTat1.3, VSG224) with two O-linked post-translational modifications | 分子名称: | Variant surface glycoprotein, alpha-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Gkeka, A, Arest-Branco, F, Stebbins, C.E, Papavasiliou, F.N. | 登録日 | 2021-07-14 | 公開日 | 2022-07-27 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | 主引用文献 | Immunodominant surface epitopes power immune evasion in the African trypanosome. Cell Rep, 42, 2023
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4TYE
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![BU of 4tye by Molmil](/molmil-images/mine/4tye) | Structural analysis of the human Fibroblast Growth Factor Receptor 4 Kinase | 分子名称: | Fibroblast growth factor receptor 4, PHOSPHATE ION | 著者 | Lesca, E, Lammens, A, Huber, R, Augustin, M. | 登録日 | 2014-07-08 | 公開日 | 2014-09-24 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural analysis of the human fibroblast growth factor receptor 4 kinase. J.Mol.Biol., 426, 2014
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4TXY
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![BU of 4txy by Molmil](/molmil-images/mine/4txy) | Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase, a prokaryotic cGAS homolog | 分子名称: | Cyclic AMP-GMP synthase, MAGNESIUM ION | 著者 | Kranzusch, P.J, Lee, A.S.Y, Wilson, S.C, Solovykh, M.S, Vance, R.E, Berger, J.M, Doudna, J.A. | 登録日 | 2014-07-07 | 公開日 | 2014-08-13 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.0001 Å) | 主引用文献 | Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity. Cell, 158, 2014
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4TYH
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![BU of 4tyh by Molmil](/molmil-images/mine/4tyh) | Ternary complex of P38 and MK2 with a P38 inhibitor | 分子名称: | MAP kinase-activated protein kinase 2, Mitogen-activated protein kinase 14, N-[5-(dimethylsulfamoyl)-2-methylphenyl]-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide | 著者 | Cumming, J.G, Debreczeni, J.E, Edfeldt, F, Evertsson, F, Harrison, M, Holdgate, G, James, M, Lamont, S, Oldham, K, Sullivan, J.E, Wells, S. | 登録日 | 2014-07-08 | 公開日 | 2015-07-22 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Discovery of substrate selective, ATP-competitive P38 alpha MAP kinase inhibitors To Be Published
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8ONN
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![BU of 8onn by Molmil](/molmil-images/mine/8onn) | Crystal structure of D-amino acid aminotransferase from Aminobacterium colombiense point mutant E113A complexed with 3-aminooxypropionic acid | 分子名称: | 3-[(~{E})-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]oxypropanoic acid, Aminotransferase class IV | 著者 | Matyuta, I.O, Boyko, K.M, Minyaev, M.E, Shilova, S.A, Bezsudnova, E.Y, Popov, V.O. | 登録日 | 2023-04-03 | 公開日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | In search for structural targets for engineering d-amino acid transaminase: modulation of pH optimum and substrate specificity. Biochem.J., 480, 2023
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6XNN
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![BU of 6xnn by Molmil](/molmil-images/mine/6xnn) | Crystal Structure of Mouse STING CTD complex with SR-717. | 分子名称: | 4,5-difluoro-2-{[6-(1H-imidazol-1-yl)pyridazine-3-carbonyl]amino}benzoic acid, Stimulator of interferon genes protein | 著者 | Chin, E.N, Yu, C, Wolan, D.W, Petrassi, H.M, Lairson, L.L. | 登録日 | 2020-07-03 | 公開日 | 2020-08-26 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic. Science, 369, 2020
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7PHP
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![BU of 7php by Molmil](/molmil-images/mine/7php) | Structure of Multidrug and Toxin Compound Extrusion (MATE) transporter NorM by NabFab-fiducial assisted cryo-EM | 分子名称: | Anti-Fab nanobody, Multidrug resistance protein NorM, NabFab HC, ... | 著者 | Bloch, J.S, Mukherjee, S, Kowal, J, Niederer, M, Pardon, E, Steyaert, J, Kossiakoff, A.A, Locher, K.P. | 登録日 | 2021-08-18 | 公開日 | 2021-09-01 | 最終更新日 | 2021-12-01 | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | 主引用文献 | Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins. Proc.Natl.Acad.Sci.USA, 118, 2021
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4TXD
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4TZI
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![BU of 4tzi by Molmil](/molmil-images/mine/4tzi) | Structure of unliganded Lyn SH2 domain | 分子名称: | Tyrosine-protein kinase Lyn | 著者 | Wybenga-Groot, L.E. | 登録日 | 2014-07-10 | 公開日 | 2015-01-21 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Tyrosine Phosphorylation of the Lyn Src Homology 2 (SH2) Domain Modulates Its Binding Affinity and Specificity. Mol.Cell Proteomics, 14, 2015
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6M9A
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![BU of 6m9a by Molmil](/molmil-images/mine/6m9a) | Bordetella pertussis globin coupled sensor regulatory domain (BpeGReg) | 分子名称: | CALCIUM ION, HYDROGEN PEROXIDE, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Rivera, S.R, Hoffer, E.D, Dunham, C.M, Weinert, E.E. | 登録日 | 2018-08-23 | 公開日 | 2018-11-14 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural Insights into Oxygen-Dependent Signal Transduction within Globin Coupled Sensors. Inorg Chem, 57, 2018
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4U28
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![BU of 4u28 by Molmil](/molmil-images/mine/4u28) | Crystal structure of apo Phosphoribosyl isomerase A from Streptomyces sviceus ATCC 29083 | 分子名称: | PHOSPHATE ION, Phosphoribosyl isomerase A | 著者 | Chang, C, Verduzco-Castro, E.A, Endres, M, Barona-Gomez, F, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2014-07-16 | 公開日 | 2014-07-30 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.33 Å) | 主引用文献 | Co-occurrence of analogous enzymes determines evolution of a novel ( beta alpha )8-isomerase sub-family after non-conserved mutations in flexible loop. Biochem. J., 473, 2016
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4U7E
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![BU of 4u7e by Molmil](/molmil-images/mine/4u7e) | The crystal structure of the complex of LIP5 NTD and IST1 MIM | 分子名称: | IST1 homolog, Vacuolar protein sorting-associated protein VTA1 homolog | 著者 | Guo, E.Z, Xu, Z. | 登録日 | 2014-07-30 | 公開日 | 2015-02-11 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Distinct Mechanisms of Recognizing Endosomal Sorting Complex Required for Transport III (ESCRT-III) Protein IST1 by Different Microtubule Interacting and Trafficking (MIT) Domains. J.Biol.Chem., 290, 2015
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7NL0
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![BU of 7nl0 by Molmil](/molmil-images/mine/7nl0) | Cryo-EM structure of the Lin28B nucleosome core particle | 分子名称: | DNA (131-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | 著者 | Roberts, G.A, Ozkan, B, Gachulincova, I, O Dwyer, M.R, Hall-Ponsele, E, Saxena, M, Robinson, P.J, Soufi, A. | 登録日 | 2021-02-19 | 公開日 | 2021-08-11 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Dissecting OCT4 defines the role of nucleosome binding in pluripotency. Nat.Cell Biol., 23, 2021
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5HP1
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7N86
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![BU of 7n86 by Molmil](/molmil-images/mine/7n86) | Crystal Structure of Human Protocadherin-24 EC1-2 Form II | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, CHLORIDE ION, ... | 著者 | Modak, D, Gray, M.E, Sotomayor, M. | 登録日 | 2021-06-13 | 公開日 | 2021-09-01 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.175 Å) | 主引用文献 | Heterophilic and homophilic cadherin interactions in intestinal intermicrovillar links are species dependent. Plos Biol., 19, 2021
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