6YCR
 
 | | Structure of human PD-L1 in complex with inhibitor | | 分子名称: | FFIVIRDRVFR(CCS)G(NH2), Programmed cell death 1 ligand 1 | | 著者 | Magiera-Mularz, K, Grudnik, P, Kuska, K, Holak, T.A, Dubin, G. | | 登録日 | 2020-03-18 | | 公開日 | 2021-02-03 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | | 主引用文献 | Macrocyclic Peptide Inhibitor of PD-1/PD-L1 Immune Checkpoint
Adv. Ther., 2020
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4INK
 | | Crystal structure of SplD protease from Staphylococcus aureus at 1.56 A resolution | | 分子名称: | Serine protease SplD | | 著者 | Zdzalik, M, Kalinska, M, Cichon, P, Wysocka, M, Stec-Niemczyk, J, Stennicke, H.R, Jabaiah, A, Markiewicz, M, Wladyka, B, Daugherty, P.S, Lesner, A, Rolka, K, Dubin, A, Potempa, J, Dubin, G. | | 登録日 | 2013-01-04 | | 公開日 | 2013-10-30 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | | 主引用文献 | Biochemical and Structural Characterization of SplD Protease from Staphylococcus aureus.
Plos One, 8, 2013
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4INL
 | | Crystal structure of SplD protease from Staphylococcus aureus at 2.1 A resolution | | 分子名称: | Serine protease SplD | | 著者 | Cichon, P, Zdzalik, M, Kalinska, M, Wysocka, M, Stec-Niemczyk, J, Stennicke, H.R, Jabaiah, A, Markiewicz, M, Wladyka, B, Daugherty, P.S, Lesner, A, Rolka, K, Dubin, A, Potempa, J, Dubin, G. | | 登録日 | 2013-01-04 | | 公開日 | 2013-10-30 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Biochemical and Structural Characterization of SplD Protease from Staphylococcus aureus.
Plos One, 8, 2013
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8GGH
 | | Structure of Trypanosoma (MDH)4-PEX5, distal conformation | | 分子名称: | Peroxisome targeting signal 1 receptor, malate dehydrogenase | | 著者 | Sonani, R.R, Artur, B, Jemiola-Rzeminska, M, Lipinski, O, Patel, S.N, Sood, T, Dubin, G. | | 登録日 | 2023-03-08 | | 公開日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | | 主引用文献 | Structure of Trypanosoma (MDH)4-PEX5, distal conformation
To Be Published
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8GH2
 | | Structure of Trypanosoma (MDH)4-(Pex5)2, close conformation | | 分子名称: | Peroxisome targeting signal 1 receptor, malate dehydrogenase | | 著者 | Sonani, R.R, Artur, B, Jemiola-Rzeminska, M, Lipinski, O, Patel, S.N, Sood, T, Dubin, G. | | 登録日 | 2023-03-09 | | 公開日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.66 Å) | | 主引用文献 | Structure of Trypanosoma (MDH)4-(Pex5)2, close conformation
To Be Published
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8GGD
 | | Structure of Trypanosoma (MDH)4-Pex5, close conformation | | 分子名称: | Peroxisome targeting signal 1 receptor, malate dehydrogenase | | 著者 | Sonani, R.R, Artur, B, Jemiola-Rzeminska, M, Lipinski, O, Patel, S.N, Sood, T, Dubin, G. | | 登録日 | 2023-03-08 | | 公開日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.33 Å) | | 主引用文献 | Structure of Trypanosoma (MDH)4-Pex5, close conformation
To Be Published
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8GH3
 | | Structure of Trypanosoma (MDH)4-(Pex5)2, distal conformation | | 分子名称: | Peroxisome targeting signal 1 receptor, malate dehydrogenase | | 著者 | Sonani, R.R, Artur, B, Jemiola-Rzeminska, M, Lipinski, O, Patel, S.N, Sood, T, Dubin, G. | | 登録日 | 2023-03-09 | | 公開日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.53 Å) | | 主引用文献 | Structure of Trypanosoma (MDH)4-(Pex5)2, distal conformation
To Be Published
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8GI0
 | | Structure of Trypanosoma docking complex | | 分子名称: | Peroxisomal membrane protein PEX14, Peroxisome targeting signal 1 receptor, malate dehydrogenase | | 著者 | Sonani, R.R, Artur, B, Jemiola-Rzeminska, M, Lipinski, O, Patel, S.N, Sood, T, Dubin, G. | | 登録日 | 2023-03-13 | | 公開日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structure of Trypanosoma docking complex
To Be Published
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6RT2
 | | Crystal structure of Trypanosoma Brucei PEX14 N-terminal domain in complex with small molecules designed to investigate the water envelope | | 分子名称: | (3~{S})-3-[[1-(2-hydroxyethyl)-5-[(4-methoxynaphthalen-1-yl)methyl]-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridin-3-yl]carbonylamino]-3-phenyl-propanoic acid, BETA-MERCAPTOETHANOL, Peroxin 14, ... | | 著者 | Napolitano, V, Ratkova, E.L, Dawidowski, M, Dubin, G, Fino, R, Popowicz, G, Sattler, M, Tetko, I.V. | | 登録日 | 2019-05-22 | | 公開日 | 2020-04-08 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Water envelope has a critical impact on the design of protein-protein interaction inhibitors.
Chem.Commun.(Camb.), 56, 2020
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7QRC
 | | X-ray structure of Trypanosoma cruzi PEX14 in complex with a PEX5-PEX14 PPI inhibitor | | 分子名称: | GLYCEROL, Peroxin-14, ~{N}-(5-ethyl-6-oxidanylidene-benzo[b][1,4]benzothiazepin-2-yl)-2-(4-fluorophenyl)ethanamide | | 著者 | Napolitano, V, Popowicz, G.M, Dawidowski, M, Dubin, G. | | 登録日 | 2022-01-10 | | 公開日 | 2022-11-23 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | | 主引用文献 | Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma.
Eur.J.Med.Chem., 243, 2022
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7QOZ
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8OIG
 | | Crystal Structure of Staphopain C from Staphylococcus aureus | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ... | | 著者 | McEwen, A.G, Magoch, M, Napolitano, V, Dubin, G, Wladyka, B. | | 登録日 | 2023-03-22 | | 公開日 | 2023-06-21 | | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | | 主引用文献 | Crystal Structure of Staphopain C from Staphylococcus aureus.
Molecules, 28, 2023
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7Q86
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7Q84
 | | Crystal structure of human peroxisomal acyl-Co-A oxidase 1a, apo-form | | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | 著者 | Sonani, R.R, Blat, A, Dubin, G. | | 登録日 | 2021-11-10 | | 公開日 | 2022-03-02 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structures of apo- and FAD-bound human peroxisomal acyl-CoA oxidase provide mechanistic basis explaining clinical observations.
Int.J.Biol.Macromol., 205, 2022
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5C3T
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5EPW
 | | C-Terminal Domain Of Human Coronavirus Nl63 Nucleocapsid Protein | | 分子名称: | Nucleoprotein | | 著者 | Szelazek, B, Kabala, W, Kus, K, Zdzalik, M, Golik, P, Florek, D, Burmistrz, M, Pyrc, K, Dubin, G. | | 登録日 | 2015-11-12 | | 公開日 | 2017-02-22 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural Characterization of Human Coronavirus NL63 N Protein.
J. Virol., 91, 2017
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8C3R
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8C3Q
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8C3G
 | | Crystal structure of DYRK1A in complex with AZ191 | | 分子名称: | 1,2-ETHANEDIOL, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-(1-methylpyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine, ... | | 著者 | Grygier, P, Pustelny, K, Dubin, G, Czarna, A. | | 登録日 | 2022-12-23 | | 公開日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | | 主引用文献 | Structural perspective on the design of selective DYRK1B inhibitors
To Be Published
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6GVX
 | | Crystal structure of Maternal Embryonic Leucine Zipper Kinase (MELK) in complex with dorsomorphin (Compound C) | | 分子名称: | 1,2-ETHANEDIOL, 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, Maternal embryonic leucine zipper kinase | | 著者 | Golik, P, Rembacz, K.P, Zrubek, K, Romanowska, M, Bugusz, J, Wladyka, B, Dubin, G. | | 登録日 | 2018-06-21 | | 公開日 | 2019-05-29 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | | 主引用文献 | Crystal structure of Maternal Embryonic Leucine Zipper Kinase (MELK) in complex with dorsomorphin (Compound C).
Arch.Biochem.Biophys., 671, 2019
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7R2V
 | | Structure of nsp14 from SARS-CoV-2 in complex with SAH | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, Proofreading exoribonuclease nsp14, ... | | 著者 | Czarna, A, Plewka, J, Kresik, L, Matsuda, A, Abdulkarim, K, Robinson, C, OByrne, S, Cunningham, F, Georgiou, I, Pachota, M, Popowicz, G.M, Wyatt, P.G, Dubin, G, Pyrc, K. | | 登録日 | 2022-02-06 | | 公開日 | 2022-03-09 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | | 主引用文献 | Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activity.
Structure, 30, 2022
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4TRP
 | | Crystal structure of monoclonal antibody against neuroblastoma associated antigen. | | 分子名称: | Heavy chain of monoclonal antibody against neuroblastoma associated antigen, Light chain of monoclonal antibody against neuroblastoma associated antigen | | 著者 | Horwacik, I, Golik, P, Grudnik, P, Zdzalik, M, Rokita, H, Dubin, G. | | 登録日 | 2014-06-17 | | 公開日 | 2015-07-15 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Structural Basis of GD2 Ganglioside and Mimetic Peptide Recognition by 14G2a Antibody.
Mol.Cell Proteomics, 14, 2015
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4TUL
 | | Crystal structure of monoclonal antibody against neuroblastoma associated antigen. | | 分子名称: | ACETATE ION, Heavy chain of monoclonal antibody against neuroblastoma associated antigen, Light chain of monoclonal antibody against neuroblastoma associated antigen, ... | | 著者 | Golik, P, Grudnik, P, Dubin, G, Zdzalik, M, Rokita, H, Horwacik, I. | | 登録日 | 2014-06-24 | | 公開日 | 2015-07-15 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Structural Basis of GD2 Ganglioside and Mimetic Peptide Recognition by 14G2a Antibody.
Mol.Cell Proteomics, 14, 2015
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4TUJ
 | | Crystal structure of monoclonal antibody against neuroblastoma associated antigen. | | 分子名称: | Heavy chain of monoclonal antibody against neuroblastoma associated antigen, Light chain of monoclonal antibody against neuroblastoma associated antigen, peptide1 | | 著者 | Grudnik, P, Golik, P, Horwacik, I, Zdzalik, M, Rokita, H, Dubin, G. | | 登録日 | 2014-06-24 | | 公開日 | 2015-07-15 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | Structural Basis of GD2 Ganglioside and Mimetic Peptide Recognition by 14G2a Antibody.
Mol.Cell Proteomics, 14, 2015
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4TUK
 | | Crystal structure of monoclonal antibody against neuroblastoma associated antigen. | | 分子名称: | CHLORIDE ION, Heavy chain of monoclonal antibody against neuroblastoma associated antigen, Light chain of monoclonal antibody against neuroblastoma associated antigen, ... | | 著者 | Golik, P, Grudnik, P, Dubin, G, Horwacik, I, Zdzalik, M, Rokita, H. | | 登録日 | 2014-06-24 | | 公開日 | 2015-07-15 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural Basis of GD2 Ganglioside and Mimetic Peptide Recognition by 14G2a Antibody.
Mol.Cell Proteomics, 14, 2015
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