8C3G

Crystal structure of DYRK1A in complex with AZ191

Summary for 8C3G

• Entry DOI: 10.2210/pdb8c3g/pdb
• Descriptor: Dual specificity tyrosine-phosphorylation-regulated kinase 1A, N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-(1-methylpyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: kinase, diabetes, kinase inhibitor, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 177143.45

Authors

Grygier, P.,Pustelny, K.,Dubin, G.,Czarna, A. (deposition date: 2022-12-23, release date: 2024-01-10, Last modification date: 2024-11-06)

• Primary citation: Grygier, P.,Pustelny, K.,Dubin, G.,Czarna, A.; Structural perspective on the design of selective DYRK1B inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.08 Å)