8C3G
Crystal structure of DYRK1A in complex with AZ191
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | polymer | 371 | 43311.8 | 4 | UniProt (Q13627) Pfam (PF00069) In PDB | Homo sapiens (human) | Dual specificity YAK1-related kinase,HP86,Protein kinase minibrain homolog,MNBH,hMNB |
2 | C, A, D, B | N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-(1-methylpyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine | non-polymer | 429.5 | 4 | Chemie (QS0) | |||
3 | C, A, D, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 32 | Chemie (EDO) | |||
4 | D, B | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
5 | water | water | 18.0 | 804 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 126 - 489 (UniProt: Q13627)
PDB | External Database | Details |
---|---|---|
Met 125 | - | initiating methionine |
His 490 | - | expression tag |
His 491 | - | expression tag |
His 492 | - | expression tag |
His 493 | - | expression tag |
His 494 | - | expression tag |
His 495 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 173247.1 | |
Non-Polymers* | Number of molecules | 38 |
Total formula weight | 3896.4 | |
All* | Total formula weight | 177143.4 |