2G8N
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![BU of 2g8n by Molmil](/molmil-images/mine/2g8n) | Structure of hPNMT with inhibitor 3-Hydroxymethyl-7-(N-4-chlorophenylaminosulfonyl)-THIQ and AdoHcy | Descriptor: | (3R)-N-(4-CHLOROPHENYL)-3-(HYDROXYMETHYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Drinkwater, N, Gee, C.L, Martin, J.L. | Deposit date: | 2006-03-02 | Release date: | 2006-09-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Comparison of the Binding of 3-Fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with Their Isosteric Sulfonamides to the Active Site of Phenylethanolamine N-Methyltransferase J.Med.Chem., 49, 2006
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6EE3
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![BU of 6ee3 by Molmil](/molmil-images/mine/6ee3) | X-ray crystal structure of Pf-M1 in complex with inhibitor (6k) and catalytic zinc ion | Descriptor: | (1R,2r,3S,5R,7R)-N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)ethyl]tricyclo[3.3.1.1~3,7~]decane-2-carboxamide, GLYCEROL, M1 family aminopeptidase, ... | Authors: | Drinkwater, N, McGowan, S. | Deposit date: | 2018-08-13 | Release date: | 2018-12-26 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases. J. Med. Chem., 62, 2019
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6EED
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![BU of 6eed by Molmil](/molmil-images/mine/6eed) | X-ray crystal structure of Pf-M1 in complex with inhibitor (6p) and catalytic zinc ion | Descriptor: | (2R)-2-[(cyclohexylacetyl)amino]-N-hydroxy-2-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)acetamide, DIMETHYL SULFOXIDE, GLYCEROL, ... | Authors: | Drinkwater, N, McGowan, S. | Deposit date: | 2018-08-13 | Release date: | 2018-12-26 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases. J. Med. Chem., 62, 2019
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6EA2
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![BU of 6ea2 by Molmil](/molmil-images/mine/6ea2) | |
6EAB
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![BU of 6eab by Molmil](/molmil-images/mine/6eab) | |
6EAA
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![BU of 6eaa by Molmil](/molmil-images/mine/6eaa) | |
4J4P
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![BU of 4j4p by Molmil](/molmil-images/mine/4j4p) | The complex of human IgE-Fc with two bound Fab fragments | Descriptor: | Ig epsilon chain C region, Immunoglobulin G Fab Fragment Heavy Chain, Immunoglobulin G Fab Fragment Light Chain, ... | Authors: | Drinkwater, N, Sutton, B.J. | Deposit date: | 2013-02-07 | Release date: | 2014-03-12 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.91 Å) | Cite: | Human immunoglobulin E flexes between acutely bent and extended conformations. Nat.Struct.Mol.Biol., 21, 2014
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4ZX3
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![BU of 4zx3 by Molmil](/molmil-images/mine/4zx3) | |
4ZY1
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![BU of 4zy1 by Molmil](/molmil-images/mine/4zy1) | |
4ZX5
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![BU of 4zx5 by Molmil](/molmil-images/mine/4zx5) | |
4ZW5
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![BU of 4zw5 by Molmil](/molmil-images/mine/4zw5) | |
4ZW6
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![BU of 4zw6 by Molmil](/molmil-images/mine/4zw6) | |
4ZW3
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![BU of 4zw3 by Molmil](/molmil-images/mine/4zw3) | |
4ZX4
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![BU of 4zx4 by Molmil](/molmil-images/mine/4zx4) | |
4ZX8
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![BU of 4zx8 by Molmil](/molmil-images/mine/4zx8) | |
4ZW7
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![BU of 4zw7 by Molmil](/molmil-images/mine/4zw7) | |
4ZYQ
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![BU of 4zyq by Molmil](/molmil-images/mine/4zyq) | |
4ZW8
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![BU of 4zw8 by Molmil](/molmil-images/mine/4zw8) | |
4ZY0
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![BU of 4zy0 by Molmil](/molmil-images/mine/4zy0) | |
4ZX6
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![BU of 4zx6 by Molmil](/molmil-images/mine/4zx6) | |
4ZY2
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![BU of 4zy2 by Molmil](/molmil-images/mine/4zy2) | X-ray crystal structure of PfA-M17 in complex with hydroxamic acid-based inhibitor 10o | Descriptor: | CARBONATE ION, DIMETHYL SULFOXIDE, N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluorobiphenyl-4-yl)ethyl]-2,2-dimethylpropanamide, ... | Authors: | Drinkwater, N, McGowan, S. | Deposit date: | 2015-05-21 | Release date: | 2016-03-30 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016
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4ZX9
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![BU of 4zx9 by Molmil](/molmil-images/mine/4zx9) | |
5JQK
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![BU of 5jqk by Molmil](/molmil-images/mine/5jqk) | |
5JR6
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![BU of 5jr6 by Molmil](/molmil-images/mine/5jr6) | |
2ONY
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![BU of 2ony by Molmil](/molmil-images/mine/2ony) | Structure of hPNMT with inhibitor 7-(N-4-chlorophenylaminosulfonyl)-THIQ and AdoHcy | Descriptor: | N-(4-CHLOROPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE, PHOSPHATE ION, Phenylethanolamine N-methyltransferase, ... | Authors: | Drinkwater, N, Martin, J.L. | Deposit date: | 2007-01-24 | Release date: | 2007-10-09 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Enzyme Adaptation to Inhibitor Binding: A Cryptic Binding Site in Phenylethanolamine N-Methyltransferase J.Med.Chem., 50, 2007
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