5W1H
 
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5VVJ
 | | Cas1-Cas2 bound to half-site intermediate | | Descriptor: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (112-MER), ... | | Authors: | Wright, A.V, Knott, G.J, Doxzen, K.W, Doudna, J.A. | | Deposit date: | 2017-05-19 | | Release date: | 2017-08-02 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.89 Å) | | Cite: | Structures of the CRISPR genome integration complex.
Science, 357, 2017
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5DS6
 | | Crystal structure the Escherichia coli Cas1-Cas2 complex bound to protospacer DNA with splayed ends | | Descriptor: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (28-MER), ... | | Authors: | Nunez, J.K, Harrington, L.B, Kranzusch, P.J, Engelman, A.N, Doudna, J.A. | | Deposit date: | 2015-09-16 | | Release date: | 2015-10-28 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.352 Å) | | Cite: | Foreign DNA capture during CRISPR-Cas adaptive immunity.
Nature, 527, 2015
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5W1I
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2AAO
 | | Regulatory apparatus of Calcium Dependent protein kinase from Arabidopsis thaliana | | Descriptor: | CALCIUM ION, Calcium-dependent protein kinase, isoform AK1 | | Authors: | Chandran, V, Stollar, E.J, Lindorff-Larsen, K, Harper, J.F, Chazin, W.J, Dobson, C.M, Luisi, B.F, Christodoulou, J. | | Deposit date: | 2005-07-13 | | Release date: | 2005-12-27 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure of the regulatory apparatus of a calcium-dependent protein kinase (CDPK): a novel mode of calmodulin-target recognition.
J.Mol.Biol., 357, 2006
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2Y9H
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2K0E
 | | A Coupled Equilibrium Shift Mechanism in Calmodulin-Mediated Signal Transduction | | Descriptor: | CALCIUM ION, Calmodulin | | Authors: | Gsponer, J, Christodoulou, J, Cavalli, A, Bui, J.M, Richter, B, Dobson, C.M, Vendruscolo, M. | | Deposit date: | 2008-02-02 | | Release date: | 2008-06-10 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | A coupled equilibrium shift mechanism in calmodulin-mediated signal transduction
Structure, 16, 2008
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2K0F
 | | Calmodulin complexed with calmodulin-binding peptide from smooth muscle myosin light chain kinase | | Descriptor: | 19-mer peptide from Myosin light chain kinase, CALCIUM ION, calmodulin | | Authors: | Gsponer, J, Christodoulou, J, Cavalli, A, Bui, J.M, Richter, B, Dobson, C.M, Vendruscolo, M. | | Deposit date: | 2008-02-02 | | Release date: | 2008-06-10 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | A coupled equilibrium shift mechanism in calmodulin-mediated signal transduction
Structure, 16, 2008
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6C8U
 | | Solution structure of Musashi2 RRM1 | | Descriptor: | RNA-binding protein Musashi homolog 2 | | Authors: | Xing, M, Lan, L, Douglas, J.T, Gao, P, Hanzlik, R.P, Xu, L. | | Deposit date: | 2018-01-25 | | Release date: | 2019-01-30 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Crystal and solution structures of human oncoprotein Musashi-2 N-terminal RNA recognition motif 1.
Proteins, 2019
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5E7J
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5E7I
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4HOH
 | | RIBONUCLEASE T1 (THR93ALA MUTANT) COMPLEXED WITH 2'GMP | | Descriptor: | CALCIUM ION, GUANOSINE-2'-MONOPHOSPHATE, PROTEIN (RIBONUCLEASE T1) | | Authors: | Langhorst, U, Loris, R, Denisov, V.P, Doumen, J, Roose, P, Maes, D, Halle, B, Steyaert, J. | | Deposit date: | 1998-09-14 | | Release date: | 1998-09-23 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Dissection of the structural and functional role of a conserved hydration site in RNase T1.
Protein Sci., 8, 1999
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1GID
 | | CRYSTAL STRUCTURE OF A GROUP I RIBOZYME DOMAIN: PRINCIPLES OF RNA PACKING | | Descriptor: | COBALT HEXAMMINE(III), MAGNESIUM ION, P4-P6 RNA RIBOZYME DOMAIN | | Authors: | Cate, J.H, Gooding, A.R, Podell, E, Zhou, K, Golden, B.L, Kundrot, C.E, Cech, T.R, Doudna, J.A. | | Deposit date: | 1996-08-22 | | Release date: | 1996-12-31 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of a group I ribozyme domain: principles of RNA packing.
Science, 273, 1996
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5E7M
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2HOH
 | | RIBONUCLEASE T1 (N9A MUTANT) COMPLEXED WITH 2'GMP | | Descriptor: | CALCIUM ION, GUANOSINE-2'-MONOPHOSPHATE, PHOSPHATE ION, ... | | Authors: | Langhorst, U, Loris, R, Denisov, V.P, Doumen, J, Roose, P, Maes, D, Halle, B, Steyaert, J. | | Deposit date: | 1998-09-14 | | Release date: | 1998-09-23 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Dissection of the structural and functional role of a conserved hydration site in RNase T1.
Protein Sci., 8, 1999
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7M5O
 | | Cryo-EM structure of CasPhi-2 (Cas12j) bound to crRNA | | Descriptor: | CasPhi, ZINC ION, crRNA | | Authors: | Pausch, P, Soczek, K, Nogales, E, Doudna, J. | | Deposit date: | 2021-03-24 | | Release date: | 2021-08-04 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.54 Å) | | Cite: | DNA interference states of the hypercompact CRISPR-Cas Phi effector.
Nat.Struct.Mol.Biol., 28, 2021
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1HQ1
 | | STRUCTURAL AND ENERGETIC ANALYSIS OF RNA RECOGNITION BY A UNIVERSALLY CONSERVED PROTEIN FROM THE SIGNAL RECOGNITION PARTICLE | | Descriptor: | 4.5S RNA DOMAIN IV, MAGNESIUM ION, POTASSIUM ION, ... | | Authors: | Batey, R.T, Sagar, M.B, Doudna, J.A. | | Deposit date: | 2000-12-13 | | Release date: | 2001-01-03 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.52 Å) | | Cite: | Structural and energetic analysis of RNA recognition by a universally conserved protein from the signal recognition particle.
J.Mol.Biol., 307, 2001
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4KM5
 | | X-ray crystal structure of human cyclic GMP-AMP synthase (cGAS) | | Descriptor: | Cyclic GMP-AMP synthase, ZINC ION | | Authors: | Kranzusch, P.J, Lee, A.S.Y, Berger, J.M, Doudna, J.A. | | Deposit date: | 2013-05-08 | | Release date: | 2013-05-29 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.499 Å) | | Cite: | Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity.
Cell Rep, 3, 2013
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4PR6
 | | A Second Look at the HDV Ribozyme Structure and Dynamics. | | Descriptor: | HDV RIBOZYME SELF-CLEAVED, MAGNESIUM ION, U1 small nuclear ribonucleoprotein A | | Authors: | Kapral, G.J, Jain, S, Noeske, J, Doudna, J.A, Richardson, D.C, Richardson, J.S. | | Deposit date: | 2014-03-05 | | Release date: | 2014-10-29 | | Last modified: | 2014-11-26 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | New tools provide a second look at HDV ribozyme structure, dynamics and cleavage.
Nucleic Acids Res., 42, 2014
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3HOH
 | | RIBONUCLEASE T1 (THR93GLN MUTANT) COMPLEXED WITH 2'GMP | | Descriptor: | CALCIUM ION, GUANOSINE-2'-MONOPHOSPHATE, PROTEIN (RIBONUCLEASE T1) | | Authors: | Langhorst, U, Loris, R, Denisov, V.P, Doumen, J, Roose, P, Maes, D, Halle, B, Steyaert, J. | | Deposit date: | 1998-09-11 | | Release date: | 1998-09-16 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Dissection of the structural and functional role of a conserved hydration site in RNase T1.
Protein Sci., 8, 1999
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4I0C
 | | The structure of the camelid antibody cAbHuL5 in complex with human lysozyme | | Descriptor: | CHLORIDE ION, GLYCEROL, Lysozyme C, ... | | Authors: | De Genst, E, Chan, P.H, Pardon, E, Kumita, J.R, Christodoulou, J, Menzer, L, Chirgadze, D.Y, Robinson, C.V, Muyldermans, S, Matagne, A, Wyns, L, Dobson, C.M, Dumoulin, M. | | Deposit date: | 2012-11-16 | | Release date: | 2013-10-09 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | A nanobody binding to non-amyloidogenic regions of the protein human lysozyme enhances partial unfolding but inhibits amyloid fibril formation.
J.Phys.Chem.B, 117, 2013
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4P6I
 | | Crystal structure of the Cas1-Cas2 complex from Escherichia coli | | Descriptor: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2 | | Authors: | Nunez, J.K, Kranzusch, P.J, Noeske, J, Doudna, J.A. | | Deposit date: | 2014-03-24 | | Release date: | 2014-05-07 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Cas1-Cas2 complex formation mediates spacer acquisition during CRISPR-Cas adaptive immunity.
Nat.Struct.Mol.Biol., 21, 2014
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1L8V
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4PRF
 | | A Second Look at the HDV Ribozyme Structure and Dynamics. | | Descriptor: | Hepatitis Delta virus ribozyme, STRONTIUM ION, U1 small nuclear ribonucleoprotein A | | Authors: | Kapral, G.J, Jain, S, Noeske, J, Doudna, J.A, Richardson, D.C, Richardson, J.S. | | Deposit date: | 2014-03-05 | | Release date: | 2014-10-29 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.395 Å) | | Cite: | New tools provide a second look at HDV ribozyme structure, dynamics and cleavage.
Nucleic Acids Res., 42, 2014
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2MEZ
 | | Flexible anchoring of archaeal MBF1 on ribosomes suggests role as recruitment factor | | Descriptor: | Multiprotein Bridging Factor (MBP-like) | | Authors: | Launay, H, Blombarch, F, Camilloni, C, Vendruscolo, M, van des Oost, J, Christodoulou, J. | | Deposit date: | 2013-10-03 | | Release date: | 2014-06-25 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Archaeal MBF1 binds to 30S and 70S ribosomes via its helix-turn-helix domain.
Biochem.J., 462, 2014
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