1EM8
 
 | | Crystal structure of chi and psi subunit heterodimer from DNA POL III | | Descriptor: | DNA POLYMERASE III CHI SUBUNIT, DNA POLYMERASE III PSI SUBUNIT | | Authors: | Gulbis, J.M, Finkelstein, J, O'Donnell, M, Kuriyan, J. | | Deposit date: | 2000-03-16 | | Release date: | 2003-08-26 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structure of the chi:psi sub-assembly of the Escherichia coli DNA polymerase clamp-loader complex.
Eur.J.Biochem., 271, 2004
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6PTO
 | | Structure of Ctf4 trimer in complex with three CMG helicases | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, DNA polymerase alpha-binding protein, ... | | Authors: | Yuan, Z, Georgescu, R, Bai, L, Santos, R, Donnell, M, Li, H. | | Deposit date: | 2019-07-16 | | Release date: | 2019-11-20 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (7 Å) | | Cite: | Ctf4 organizes sister replisomes and Pol alpha into a replication factory.
Elife, 8, 2019
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6PTN
 | | Structure of Ctf4 trimer in complex with two CMG helicases | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, DNA polymerase alpha-binding protein, ... | | Authors: | Yuan, Z, Georgescu, R, Bai, L, Santos, R, Donnell, M, Li, H. | | Deposit date: | 2019-07-16 | | Release date: | 2019-11-20 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (5.8 Å) | | Cite: | Ctf4 organizes sister replisomes and Pol alpha into a replication factory.
Elife, 8, 2019
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6PTJ
 | | Structure of Ctf4 trimer in complex with one CMG helicase | | Descriptor: | Cell division control protein 45, DNA polymerase alpha-binding protein, DNA replication complex GINS protein PSF1, ... | | Authors: | Yuan, Z, Georgescu, R, Bai, L, Santos, R, Donnell, M, Li, H. | | Deposit date: | 2019-07-15 | | Release date: | 2019-11-20 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Ctf4 organizes sister replisomes and Pol alpha into a replication factory.
Elife, 8, 2019
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2HNH
 | | Crystal structure of the catalytic alpha subunit of E. coli replicative DNA polymerase III | | Descriptor: | DNA polymerase III alpha subunit, PHOSPHATE ION | | Authors: | Meindert, M.H, Georgescu, R.E, Lee, S, O'Donnell, M, Kuriyan, J. | | Deposit date: | 2006-07-12 | | Release date: | 2006-09-19 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal Structure of the Catalytic alpha Subunit of E. coli Replicative DNA Polymerase III.
Cell(Cambridge,Mass.), 126, 2006
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2HQA
 | | Crystal structure of the catalytic alpha subunit of E. Coli replicative DNA polymerase III | | Descriptor: | DNA polymerase III alpha subunit, PHOSPHATE ION | | Authors: | Lamers, M.H, Georgescu, R.E, Lee, S.G, O'Donnell, M, Kuriyan, J. | | Deposit date: | 2006-07-18 | | Release date: | 2006-09-19 | | Last modified: | 2017-10-18 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal Structure of the Catalytic alpha Subunit of E. coli Replicative DNA Polymerase III.
Cell(Cambridge,Mass.), 126, 2006
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3U5Z
 | | Structure of T4 Bacteriophage clamp loader bound to the T4 clamp, primer-template DNA, and ATP analog | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA polymerase accessory protein 44, DNA polymerase accessory protein 62, ... | | Authors: | Kelch, B.A, Makino, D.L, O'Donnell, M, Kuriyan, J. | | Deposit date: | 2011-10-11 | | Release date: | 2012-01-04 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | How a DNA polymerase clamp loader opens a sliding clamp.
Science, 334, 2011
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1EQN
 | | E.COLI PRIMASE CATALYTIC CORE | | Descriptor: | DNA PRIMASE | | Authors: | Podobnik, M, McInerney, P, O'Donnell, M, Kuriyan, J. | | Deposit date: | 2000-04-05 | | Release date: | 2000-06-30 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | A TOPRIM domain in the crystal structure of the catalytic core of Escherichia coli primase confirms a structural link to DNA topoisomerases.
J.Mol.Biol., 300, 2000
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3U60
 | | Structure of T4 Bacteriophage Clamp Loader Bound To Open Clamp, DNA and ATP Analog | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA polymerase accessory protein 44, DNA polymerase accessory protein 62, ... | | Authors: | Kelch, B.A, Makino, D.L, O'Donnell, M, Kuriyan, J. | | Deposit date: | 2011-10-11 | | Release date: | 2012-01-04 | | Method: | X-RAY DIFFRACTION (3.34 Å) | | Cite: | How a DNA polymerase clamp loader opens a sliding clamp.
Science, 334, 2011
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3U61
 | | Structure of T4 Bacteriophage Clamp Loader Bound To Closed Clamp, DNA and ATP Analog and ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA polymerase accessory protein 44, DNA polymerase accessory protein 62, ... | | Authors: | Kelch, B.A, Makino, D.L, O'Donnell, M, Kuriyan, J. | | Deposit date: | 2011-10-11 | | Release date: | 2012-01-04 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | How a DNA polymerase clamp loader opens a sliding clamp.
Science, 334, 2011
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1XXI
 | | ADP Bound E. coli Clamp Loader Complex | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA polymerase III subunit gamma, DNA polymerase III, ... | | Authors: | Kazmirski, S.L, Podobnik, M, Weitze, T.F, O'Donnell, M, Kuriyan, J. | | Deposit date: | 2004-11-05 | | Release date: | 2004-12-07 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (4.1 Å) | | Cite: | Structural analysis of the inactive state of the Escherichia coli DNA polymerase clamp-loader complex
Proc.Natl.Acad.Sci.USA, 101, 2004
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1XXH
 | | ATPgS Bound E. Coli Clamp Loader Complex | | Descriptor: | DNA polymerase III subunit gamma, DNA polymerase III, delta prime subunit, ... | | Authors: | Kazmirski, S.L, Podobnik, M, Weitze, T.F, O'Donnell, M, Kuriyan, J. | | Deposit date: | 2004-11-05 | | Release date: | 2004-12-07 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.45 Å) | | Cite: | Structural analysis of the inactive state of the Escherichia coli DNA polymerase clamp-loader complex
Proc.Natl.Acad.Sci.USA, 101, 2004
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1JQL
 | | Mechanism of Processivity Clamp Opening by the Delta Subunit Wrench of the Clamp Loader Complex of E. coli DNA Polymerase III: Structure of beta-delta (1-140) | | Descriptor: | DNA Polymerase III, BETA CHAIN, DELTA SUBUNIT | | Authors: | Jeruzalmi, D, Yurieva, O, Zhao, Y, Young, M, Stewart, J, Hingorani, M, O'Donnell, M, Kuriyan, J. | | Deposit date: | 2001-08-07 | | Release date: | 2001-09-26 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Mechanism of processivity clamp opening by the delta subunit wrench of the clamp loader complex of E. coli DNA polymerase III.
Cell(Cambridge,Mass.), 106, 2001
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1JQJ
 | | Mechanism of Processivity Clamp Opening by the Delta Subunit Wrench of the Clamp Loader Complex of E. coli DNA Polymerase III: Structure of the beta-delta complex | | Descriptor: | DNA polymerase III, beta chain, delta subunit | | Authors: | Jeruzalmi, D, Yurieva, O, Zhao, Y, Young, M, Stewart, J, Hingorani, M, O'Donnell, M, Kuriyan, J. | | Deposit date: | 2001-08-07 | | Release date: | 2001-11-07 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Mechanism of processivity clamp opening by the delta subunit wrench of the clamp loader complex of E. coli DNA polymerase III.
Cell(Cambridge,Mass.), 106, 2001
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7KC0
 | | Structure of the Saccharomyces cerevisiae replicative polymerase delta in complex with a primer/template and the PCNA clamp | | Descriptor: | 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, DNA (25-MER), DNA (5'-D(P*AP*TP*GP*AP*CP*CP*AP*TP*GP*AP*TP*TP*AP*CP*GP*AP*AP*TP*TP*GP*C)-3'), ... | | Authors: | Zheng, F, Georgescu, R, Li, H, O'Donnell, M.E. | | Deposit date: | 2020-10-04 | | Release date: | 2020-12-02 | | Last modified: | 2020-12-16 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structure of eukaryotic DNA polymerase delta bound to the PCNA clamp while encircling DNA.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6WJV
 | | Structure of the Saccharomyces cerevisiae polymerase epsilon holoenzyme | | Descriptor: | DNA polymerase epsilon catalytic subunit A, DNA polymerase epsilon subunit B, DNA polymerase epsilon subunit C, ... | | Authors: | Yuan, Z, Georgescu, R, Schauer, G.D, O'Donnell, M, Li, H. | | Deposit date: | 2020-04-14 | | Release date: | 2020-07-08 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structure of the polymerase epsilon holoenzyme and atomic model of the leading strand replisome.
Nat Commun, 11, 2020
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6U0M
 | | Structure of the S. cerevisiae replicative helicase CMG in complex with a forked DNA | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, DNA (15-MER), ... | | Authors: | Yuan, Z, Georgescu, R, Bai, L, Zhang, D, O'Donnell, M, Li, H. | | Deposit date: | 2019-08-14 | | Release date: | 2020-03-25 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | DNA unwinding mechanism of a eukaryotic replicative CMG helicase.
Nat Commun, 11, 2020
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1NJF
 | | Nucleotide bound form of an isolated E. coli clamp loader gamma subunit | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA polymerase III subunit gamma, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | | Authors: | Podobnik, M, Weitze, T.F, O'Donnell, M, Kuriyan, J. | | Deposit date: | 2002-12-30 | | Release date: | 2003-04-08 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Nucleotide-Induced Conformational Changes in an Isolated Escherichia coli DNA Polymerase III Clamp Loader Subunit
Structure, 11, 2003
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2AVT
 | | Crystal structure of the beta subunit from DNA polymerase of Streptococcus pyogenes | | Descriptor: | DNA polymerase III beta subunit | | Authors: | Argiriadi, M.A, Goedken, E.R, Bruck, I, O'donnell, M, Kuriyan, J. | | Deposit date: | 2005-08-30 | | Release date: | 2006-01-24 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of a DNA polymerase sliding clamp from a Gram-positive bacterium.
Bmc Struct.Biol., 6, 2006
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5U8S
 | | Structure of eukaryotic CMG helicase at a replication fork | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, DNA (26-MER), ... | | Authors: | Li, H, Li, B, Georgescu, R, Yuan, Z, Santos, R, Sun, J, Zhang, D, Yurieva, O, O'Donnell, M.E. | | Deposit date: | 2016-12-14 | | Release date: | 2017-01-25 | | Last modified: | 2020-01-01 | | Method: | ELECTRON MICROSCOPY (6.101 Å) | | Cite: | Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5U8T
 | | Structure of Eukaryotic CMG Helicase at a Replication Fork and Implications | | Descriptor: | Cell division control protein 45, DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), DNA replication complex GINS protein PSF1, ... | | Authors: | Li, B, Georgescu, R, Yuan, Z, Santos, R, Sun, J, Zhang, D, Yurieva, O, Li, H, O'Donnell, M.E. | | Deposit date: | 2016-12-15 | | Release date: | 2017-02-08 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (4.9 Å) | | Cite: | Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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1NJG
 | | Nucleotide-free form of an Isolated E. coli Clamp Loader Gamma Subunit | | Descriptor: | DNA polymerase III subunit gamma, SULFATE ION, ZINC ION | | Authors: | Podobnik, M, Weitze, T.F, O'Donnell, M, Kuriyan, J. | | Deposit date: | 2002-12-30 | | Release date: | 2003-04-01 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Nucleotide-Induced Conformational Changes in an Isolated Escherichia coli DNA Polymerase III Clamp Loader Subunit
Structure, 11, 2003
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1A5T
 | | CRYSTAL STRUCTURE OF THE DELTA PRIME SUBUNIT OF THE CLAMP-LOADER COMPLEX OF ESCHERICHIA COLI DNA POLYMERASE III | | Descriptor: | DELTA PRIME, ZINC ION | | Authors: | Guenther, B, Onrust, R, Sali, A, O'Donnell, M, Kuriyan, J. | | Deposit date: | 1998-02-18 | | Release date: | 1998-05-27 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of the delta' subunit of the clamp-loader complex of E. coli DNA polymerase III.
Cell(Cambridge,Mass.), 91, 1997
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1CZD
 | | CRYSTAL STRUCTURE OF THE PROCESSIVITY CLAMP GP45 FROM BACTERIOPHAGE T4 | | Descriptor: | DNA POLYMERASE ACCESSORY PROTEIN G45 | | Authors: | Moarefi, I, Jeruzalmi, D, Turner, J, O'Donnell, M, Kuriyan, J. | | Deposit date: | 1999-09-02 | | Release date: | 2000-03-03 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Crystal structure of the DNA polymerase processivity factor of T4 bacteriophage.
J.Mol.Biol., 296, 2000
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8FOJ
 | | Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in the post RNA handoff state | | Descriptor: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | | Authors: | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | | Deposit date: | 2022-12-30 | | Release date: | 2023-05-31 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (4.8 Å) | | Cite: | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase.
Nat Commun, 14, 2023
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