2AVT

Crystal structure of the beta subunit from DNA polymerase of Streptococcus pyogenes

Summary for 2AVT

• Entry DOI: 10.2210/pdb2avt/pdb
• Descriptor: DNA polymerase III beta subunit (2 entities in total)
• Functional Keywords: beta clamp, sliding clamp, polymerase, replication, transferase
• Biological source: Streptococcus pyogenes
• Total number of polymer chains: 2
• Total formula weight: 83885.12

Authors

Argiriadi, M.A.,Goedken, E.R.,Bruck, I.,O'donnell, M.,Kuriyan, J. (deposition date: 2005-08-30, release date: 2006-01-24, Last modification date: 2024-02-14)

Primary citation

Argiriadi, M.A.,Goedken, E.R.,Bruck, I.,O'donnell, M.,Kuriyan, J.
Crystal structure of a DNA polymerase sliding clamp from a Gram-positive bacterium.
Bmc Struct.Biol., 6:2-2, 2006

PubMed Abstract: Sliding DNA clamps are processivity factors that are required for efficient DNA replication. DNA polymerases maintain proximity to nucleic acid templates by interacting with sliding clamps that encircle DNA and thereby link the polymerase enzyme to the DNA substrate. Although the structures of sliding clamps from Gram-negative bacteria (E. coli), eukaryotes, archaea, and T4-like bacteriophages are well-known, the structure of a sliding clamp from Gram-positive bacteria has not been reported previously.

PubMed: 16403212
DOI: 10.1186/1472-6807-6-2

Experimental method

X-RAY DIFFRACTION (2 Å)