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PDB: 31 件
6EO6
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BU of 6eo6 by Molmil
X-ray structure of the complex between human alpha-thrombin and modified 15-mer DNA aptamer containing 5-(3-(2-(1H-indol-3-yl)acetamide-N-yl)-1-propen-1-yl)-2'-deoxyuridine residue
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, GA63A - TBA MODIFIED APTAMER, ...
著者Dolot, R.M, Nawrot, B, Yang, X.
登録日2017-10-09
公開日2017-10-25
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity.
Nucleic Acids Res., 46, 2018
6EO7
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BU of 6eo7 by Molmil
X-ray structure of the complex between human alpha-thrombin and modified 15-mer DNA aptamer containing 5-(3-(acetamide-N-yl)-1-propen-1-yl)-2'-deoxyuridine residue
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, GA68B2 - MODIFIED HUMAN THROMBIN BINDING APTAMER, ...
著者Dolot, R.M, Nawrot, B, Yang, X.
登録日2017-10-09
公開日2017-10-18
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.24 Å)
主引用文献Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity.
Nucleic Acids Res., 46, 2018
7Q2U
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BU of 7q2u by Molmil
The crystal structure of the HINT1 Q62A mutant.
分子名称: CACODYLATE ION, HEXAETHYLENE GLYCOL, Histidine triad nucleotide-binding protein 1, ...
著者Dolot, R.M, Strom, A.M, Wagner, C.R.
登録日2021-10-26
公開日2021-11-03
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Dynamic Long-Range Interactions Influence Substrate Binding and Catalysis by Human Histidine Triad Nucleotide-Binding Proteins (HINTs), Key Regulators of Multiple Cellular Processes and Activators of Antiviral ProTides.
Biochemistry, 61, 2022
4RYV
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BU of 4ryv by Molmil
Crystal structure of yellow lupin LLPR-10.1A protein in complex with trans-zeatin
分子名称: (2E)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol, Protein LLPR-10.1A, SULFATE ION
著者Dolot, R, Michalska, K, Sliwiak, J, Bujacz, G, Sikorski, M.M, Jaskolski, M.
登録日2014-12-17
公開日2015-12-09
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.38 Å)
主引用文献Crystallographic and CD probing of ligand-induced conformational changes in a plant PR-10 protein.
J.Struct.Biol., 193, 2016
8CLM
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BU of 8clm by Molmil
1.80 A crystal structure of RNA/2'-O-methyl-RNA heteroduplex
分子名称: POTASSIUM ION, RNA (5'-R(*(UZL)*(OMU)P*(A2M)P*(OMG)P*(OMG)P*(A2M)P*(OMG)P*(A2M)P*(OMC)P*)-3'), RNA (5'-R(*G*UP*CP*UP*CP*CP*UP*AP*GP*)-3'), ...
著者Dolot, R.M, Maciaszek, A, Nawrot, B.C.
登録日2023-02-16
公開日2023-03-01
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of RNA/2'-O-methyl-RNA heteroduplex
To Be Published
8CKS
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BU of 8cks by Molmil
Crystal structure of Human Serum Albumin in complex with FESAN
分子名称: 3,3'-commo-bis(1,2-dicarba-3-ferra-closo-dodecaborane), DIMETHYL SULFOXIDE, GLYCEROL, ...
著者Dolot, R.M, Kaniowski, D, Ebenryter-Olbinska, K, Szczupak, P, Suwara, J, Nawrot, B.C.
登録日2023-02-16
公開日2023-03-01
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of Human Serum Albumin in complex with FESAN
To Be Published
3TW2
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BU of 3tw2 by Molmil
High resolution structure of human histidine triad nucleotide-binding protein 1 (hHINT1)/AMP complex in a monoclinic space group
分子名称: ADENOSINE MONOPHOSPHATE, Histidine triad nucleotide-binding protein 1
著者Dolot, R.M, Wlodarczyk, A, Ozga, M, Krakowiak, A, Nawrot, B.
登録日2011-09-21
公開日2011-11-02
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.38 Å)
主引用文献A new crystal form of human histidine triad nucleotide-binding protein 1 (hHINT1) in complex with adenosine 5'-monophosphate at 1.38 A resolution.
Acta Crystallogr.,Sect.F, 68, 2012
6G9Z
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BU of 6g9z by Molmil
Crystal structure of human histidine triad nucleotide-binding protein 1 (hHINT1) crystallized at P212121 space group, with visible extended fragment of N-terminus
分子名称: (2S)-2-hydroxybutanedioic acid, Histidine triad nucleotide-binding protein 1
著者Dolot, R.M, Seda, A, Nawrot, B.C.
登録日2018-04-11
公開日2018-04-18
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.43 Å)
主引用文献Differences in crystal packing as the key factor for stabilization of the N-terminal fragment of hHINT1 protein
To Be Published
7OW0
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BU of 7ow0 by Molmil
1.55 A crystal structure of DNA/2'-O-methyl-RNA heteroduplex with overhangs solved by Zn-SAD.
分子名称: DNA (5'-D(*TP*CP*TP*CP*CP*TP*AP*GP*G)-3'), RNA (5'-R(*(OMC)P*(OMU)P*(A2M)P*(OMG)P*(OMG)P*(A2M)P*(OMG)P*(A2M)P*(OMC))-3'), ZINC ION
著者Dolot, R.M, Maciaszek, A, Nawrot, B.C.
登録日2021-06-15
公開日2021-07-14
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献First High-Resolution Crystal Structures of DNA:2'-O-Methyl-RNA Heteroduplexes
Crystals, 2022
7OXS
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BU of 7oxs by Molmil
1.91 A crystal structure of DNA/2'-O-methyl-RNA heteroduplex
分子名称: DNA (5'-D(*GP*TP*CP*TP*CP*CP*TP*AP*G)-3'), RNA (5'-R(*(OMC)P*(OMU)P*(A2M)P*(OMG)P*(OMG)P*(A2M)P*(OMG)P*(A2M)P*(OMC))-3'), SULFATE ION
著者Dolot, R.M, Maciaszek, A, Nawrot, B.C.
登録日2021-06-23
公開日2021-07-14
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献First High-Resolution Crystal Structures of DNA:2'-O-Methyl-RNA Heteroduplexes
Crystals, 2022
4ZKL
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BU of 4zkl by Molmil
Crystal structure of human histidine triad nucleotide-binding protein 1 (hHINT1) complexed with JB419 (AP4A analog)
分子名称: (2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-[2-[[(2S)-3-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-sulfanyl-phosphoryl]oxy-2-oxidanyl-propoxy]-sulfanyl-phosphoryl]oxyethyl]oxolane-3,4-diol, ADENOSINE MONOPHOSPHATE, Histidine triad nucleotide-binding protein 1
著者Dolot, R.M, Kaczmarek, R, Seda, A, Krakowiak, A, Baraniak, J, Nawrot, B.
登録日2015-04-30
公開日2016-03-02
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.34 Å)
主引用文献Crystallographic studies of the complex of human HINT1 protein with a non-hydrolyzable analog of Ap4A.
Int.J.Biol.Macromol., 87, 2016
4ZKV
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BU of 4zkv by Molmil
Crystal structure of human histidine triad nucleotide-binding protein 1 (hHINT1) refined to 1.92A at P21 space group
分子名称: Histidine triad nucleotide-binding protein 1, SULFATE ION
著者Dolot, R.M, Seda, A, Nawrot, B.
登録日2015-04-30
公開日2016-03-02
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Crystallographic studies of the complex of human HINT1 protein with a non-hydrolyzable analog of Ap4A.
Int.J.Biol.Macromol., 87, 2016
8PAF
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BU of 8paf by Molmil
Crystal structure of human Histidine Triad Nucleotide-Binding Protein 1 in complex with 5'-O-[N-(3-Indolepropionic acid)sulfamoyl] 2-aminoethenoadenosine
分子名称: 5'-O-[N-(3-Indolepropionic acid)sulfamoyl] 2-aminoethenoadenosine, Histidine triad nucleotide-binding protein 1
著者Dolot, R.M, Dillenburg, M, Wagner, C.R.
登録日2023-06-07
公開日2023-06-14
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Novel inhibitors for hHINT1 protein
To Be Published
8PA6
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BU of 8pa6 by Molmil
Crystal structure of human Histidine Triad Nucleotide-Binding Protein 1 in complex with 5'-O-[(3-Indolyl)-1-Ethyl]Carbamoyl 2-aminoethenoadenosine
分子名称: 5'-O-[(3-Indolyl)-1-Ethyl]Carbamoyl 2-aminoethenoadenosine, Histidine triad nucleotide-binding protein 1
著者Dolot, R.M, Dillenburg, M, Wagner, C.R.
登録日2023-06-07
公開日2023-06-14
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Novel inhibitors for hHINT1 protein
To Be Published
8PA9
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BU of 8pa9 by Molmil
Crystal structure of human Histidine Triad Nucleotide-Binding Protein 1 in complex with 5'-O-[(3-Indolyl)-1-Ethyl]Carbamoyl N2-methyl-2-aminoethenoadenosine
分子名称: 5'-O-[(3-Indolyl)-1-Ethyl]Carbamoyl N2-methyl-2-aminoethenoadenosine, Histidine triad nucleotide-binding protein 1
著者Dolot, R.M, Dillenburg, M, Wagner, C.R.
登録日2023-06-07
公開日2023-06-14
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Novel inhibitors for hHINT1 protein
To Be Published
8PAI
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BU of 8pai by Molmil
Crystal structure of human Histidine Triad Nucleotide-Binding Protein 1 in complex with 5'-O-[N-(3-Indolepropionic acid)sulfamoyl] N2-methyl-2-aminoethenoadenosine
分子名称: 5'-O-[N-(3-Indolepropionic acid)sulfamoyl] N2-methyl-2-aminoethenoadenosine, Histidine triad nucleotide-binding protein 1
著者Dolot, R.M, Dillenburg, M, Wagner, C.R.
登録日2023-06-07
公開日2023-06-14
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Novel inhibitors for hHINT1 protein
To Be Published
8P8P
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BU of 8p8p by Molmil
Crystal structure of human Histidine Triad Nucleotide-Binding Protein 1 in complex with 5'-O-[(3-Indolyl)-1-Ethyl]Carbamoyl Ethenoadenosine
分子名称: Histidine triad nucleotide-binding protein 1, [(2~{R},3~{S},4~{R},5~{R})-5-imidazo[2,1-f]purin-3-yl-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-[2-(1~{H}-indol-3-yl)ethyl]carbamate
著者Dolot, R.M, Dillenburg, M, Wagner, C.R.
登録日2023-06-02
公開日2023-06-14
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Novel inhibitors for hHINT1 protein
To Be Published
5O8I
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BU of 5o8i by Molmil
Crystal structure of human histidine triad nucleotide-binding protein 1 (hHINT1) crystallized at P212121 space group, and refined to 1.27 A
分子名称: ADENOSINE-5'-DIPHOSPHATE, Histidine triad nucleotide-binding protein 1
著者Dolot, R.M, Seda, A, Nawrot, B.C.
登録日2017-06-13
公開日2017-06-28
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.27 Å)
主引用文献Differences in crystal packing as the key factor for stabilization of the N-terminal fragment of hHINT1 protein
To Be Published
8OFD
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BU of 8ofd by Molmil
Crystal structure of beta-conglutin from Lupinus albus refined to 2.81 A
分子名称: ACETATE ION, Conglutin beta 1, POTASSIUM ION, ...
著者Dolot, R.M, O'Sullivan, C.K, Jauset-Rubio, M.
登録日2023-03-15
公開日2023-06-14
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献First crystal structure of beta-conglutin, a major lupin allergen from Lupinus albus seeds
To Be Published
6YQD
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BU of 6yqd by Molmil
Human histidine triad nucleotide-binding protein 2 (hHINT2) refined to 1.41 A in P212121 space group
分子名称: Histidine triad nucleotide-binding protein 2, mitochondrial, POTASSIUM ION
著者Dolot, R.D, Wlodarczyk, A, Bujacz, G.D, Nawrot, B.C.
登録日2020-04-16
公開日2020-04-29
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.407 Å)
主引用文献Biochemical, crystallographic and biophysical characterization of histidine triad nucleotide-binding protein 2 with different ligands including a non-hydrolyzable analog of Ap4A.
Biochim Biophys Acta Gen Subj, 1865, 2021
6YI0
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BU of 6yi0 by Molmil
Human histidine triad nucleotide-binding protein 2 (hHINT2) refined to 1.65 A in P41212 space group
分子名称: Histidine triad nucleotide-binding protein 2, mitochondrial, SODIUM ION
著者Dolot, R.D, Wlodarczyk, A, Bujacz, G.D, Nawrot, B.C.
登録日2020-03-31
公開日2020-04-29
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Biochemical, crystallographic and biophysical characterization of histidine triad nucleotide-binding protein 2 with different ligands including a non-hydrolyzable analog of Ap4A.
Biochim Biophys Acta Gen Subj, 1865, 2021
6YQM
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BU of 6yqm by Molmil
Human histidine triad nucleotide-binding protein 1 (hHINT1) complexed with dGMP and refined to 1.02 A
分子名称: 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, Histidine triad nucleotide-binding protein 1
著者Dolot, R.D, Seda, A, Nawrot, B.C.
登録日2020-04-17
公開日2020-04-29
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.02 Å)
主引用文献Biochemical, crystallographic and biophysical characterization of histidine triad nucleotide-binding protein 2 with different ligands including a non-hydrolyzable analog of Ap4A.
Biochim Biophys Acta Gen Subj, 1865, 2021
6YPX
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BU of 6ypx by Molmil
Human histidine triad nucleotide-binding protein 2 (hHINT2) refined to 2.11 A in C2221 space group
分子名称: CACODYLATE ION, GLYCEROL, Histidine triad nucleotide-binding protein 2, ...
著者Dolot, R.D, Wlodarczyk, A, Bujacz, G.D, Nawrot, B.C.
登録日2020-04-16
公開日2020-04-29
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献Biochemical, crystallographic and biophysical characterization of histidine triad nucleotide-binding protein 2 with different ligands including a non-hydrolyzable analog of Ap4A.
Biochim Biophys Acta Gen Subj, 1865, 2021
6YPR
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BU of 6ypr by Molmil
Human histidine triad nucleotide-binding protein 2 (hHINT2) refined to 1.26 A in H32 space group
分子名称: GLYCEROL, Histidine triad nucleotide-binding protein 2, mitochondrial
著者Dolot, R.D, Wlodarczyk, A, Bujacz, G.D, Nawrot, B.C.
登録日2020-04-16
公開日2020-04-29
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.26 Å)
主引用文献Biochemical, crystallographic and biophysical characterization of histidine triad nucleotide-binding protein 2 with different ligands including a non-hydrolyzable analog of Ap4A.
Biochim Biophys Acta Gen Subj, 1865, 2021
6YVP
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BU of 6yvp by Molmil
Human histidine triad nucleotide-binding protein 2 (hHINT2) complexed with dGMP and refined to 2.77 A
分子名称: 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, Histidine triad nucleotide-binding protein 2, mitochondrial
著者Dolot, R.D, Krakowiak, A, Nawrot, B.C.
登録日2020-04-28
公開日2020-05-13
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.77 Å)
主引用文献Biochemical, crystallographic and biophysical characterization of histidine triad nucleotide-binding protein 2 with different ligands including a non-hydrolyzable analog of Ap4A.
Biochim Biophys Acta Gen Subj, 1865, 2021

 

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