6YPX

Human histidine triad nucleotide-binding protein 2 (hHINT2) refined to 2.11 A in C2221 space group

This is a non-PDB format compatible entry.

Replaces:  4NJZ

Summary for 6YPX

• Entry DOI: 10.2210/pdb6ypx/pdb
• Related: 6YI0 6YPR
• Descriptor: Histidine triad nucleotide-binding protein 2, mitochondrial, CACODYLATE ION, GLYCEROL, ... (5 entities in total)
• Functional Keywords: nucleotide binding protein, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 69239.05

Authors

Dolot, R.D.,Wlodarczyk, A.,Bujacz, G.D.,Nawrot, B.C. (deposition date: 2020-04-16, release date: 2020-04-29, Last modification date: 2024-01-24)

Primary citation

Dolot, R.,Krakowiak, A.,Kaczmarek, R.,Wlodarczyk, A.,Pichlak, M.,Nawrot, B.
Biochemical, crystallographic and biophysical characterization of histidine triad nucleotide-binding protein 2 with different ligands including a non-hydrolyzable analog of Ap4A.
Biochim Biophys Acta Gen Subj, 1865:129968-129968, 2021

PubMed Abstract: Human HINT2 is an important mitochondrial enzyme involved in many processes such as apoptosis and bioenergetics, but its endogenous substrates and the three-dimensional structure of the full-length protein have not been identified yet.

PubMed: 34329705
DOI: 10.1016/j.bbagen.2021.129968

Experimental method

X-RAY DIFFRACTION (2.11 Å)