6YPX

Human histidine triad nucleotide-binding protein 2 (hHINT2) refined to 2.11 A in C2221 space group

This is a non-PDB format compatible entry.

Replaces:  4NJZ

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0000166	molecular_function	nucleotide binding
AAA	0003824	molecular_function	catalytic activity
AAA	0005515	molecular_function	protein binding
AAA	0005737	cellular_component	cytoplasm
AAA	0005739	cellular_component	mitochondrion
AAA	0005741	cellular_component	mitochondrial outer membrane
AAA	0005759	cellular_component	mitochondrial matrix
AAA	0006694	biological_process	steroid biosynthetic process
AAA	0006915	biological_process	apoptotic process
AAA	0016042	biological_process	lipid catabolic process
AAA	0016787	molecular_function	hydrolase activity
AAA	0043530	molecular_function	adenosine 5'-monophosphoramidase activity
AAA	2000757	biological_process	negative regulation of peptidyl-lysine acetylation
BBB	0000166	molecular_function	nucleotide binding
BBB	0003824	molecular_function	catalytic activity
BBB	0005515	molecular_function	protein binding
BBB	0005737	cellular_component	cytoplasm
BBB	0005739	cellular_component	mitochondrion
BBB	0005741	cellular_component	mitochondrial outer membrane
BBB	0005759	cellular_component	mitochondrial matrix
BBB	0006694	biological_process	steroid biosynthetic process
BBB	0006915	biological_process	apoptotic process
BBB	0016042	biological_process	lipid catabolic process
BBB	0016787	molecular_function	hydrolase activity
BBB	0043530	molecular_function	adenosine 5'-monophosphoramidase activity
BBB	2000757	biological_process	negative regulation of peptidyl-lysine acetylation
CCC	0000166	molecular_function	nucleotide binding
CCC	0003824	molecular_function	catalytic activity
CCC	0005515	molecular_function	protein binding
CCC	0005737	cellular_component	cytoplasm
CCC	0005739	cellular_component	mitochondrion
CCC	0005741	cellular_component	mitochondrial outer membrane
CCC	0005759	cellular_component	mitochondrial matrix
CCC	0006694	biological_process	steroid biosynthetic process
CCC	0006915	biological_process	apoptotic process
CCC	0016042	biological_process	lipid catabolic process
CCC	0016787	molecular_function	hydrolase activity
CCC	0043530	molecular_function	adenosine 5'-monophosphoramidase activity
CCC	2000757	biological_process	negative regulation of peptidyl-lysine acetylation
DDD	0000166	molecular_function	nucleotide binding
DDD	0003824	molecular_function	catalytic activity
DDD	0005515	molecular_function	protein binding
DDD	0005737	cellular_component	cytoplasm
DDD	0005739	cellular_component	mitochondrion
DDD	0005741	cellular_component	mitochondrial outer membrane
DDD	0005759	cellular_component	mitochondrial matrix
DDD	0006694	biological_process	steroid biosynthetic process
DDD	0006915	biological_process	apoptotic process
DDD	0016042	biological_process	lipid catabolic process
DDD	0016787	molecular_function	hydrolase activity
DDD	0043530	molecular_function	adenosine 5'-monophosphoramidase activity
DDD	2000757	biological_process	negative regulation of peptidyl-lysine acetylation

Functional Information from PROSITE/UniProt

site_id	PS00892
Number of Residues	19
Details	HIT_1 HIT domain signature. NdgklGaQsVyHLHIHVLG

Chain	Residue	Details
AAA	ASN136-GLY154

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Tele-AMP-histidine intermediate => ECO:0000269|PubMed:16762638

Chain	Residue	Details
AAA	HIS149
BBB	HIS149
CCC	HIS149
DDD	HIS149

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site_id	SWS_FT_FI2
Number of Residues	20
Details	BINDING: BINDING => ECO:0000269|PubMed:23659632, ECO:0007744|PDB:4INI

Chain	Residue	Details
AAA	SER63
BBB	HIS149
CCC	SER63
CCC	ASP80
CCC	ASN136
CCC	ALA142
CCC	HIS149
DDD	SER63
DDD	ASP80
DDD	ASN136
DDD	ALA142
AAA	ASP80
DDD	HIS149
AAA	ASN136
AAA	ALA142
AAA	HIS149
BBB	SER63
BBB	ASP80
BBB	ASN136
BBB	ALA142

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site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9D0S9

Chain	Residue	Details
AAA	LYS119
AAA	LYS139
BBB	LYS119
BBB	LYS139
CCC	LYS119
CCC	LYS139
DDD	LYS119
DDD	LYS139

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