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PDB: 174 results
6OMF
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BU of 6omf by Molmil
CryoEM structure of SigmaS-transcription initiation complex with activator Crl
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Jaramillo Cartagena, A, Darst, S.A, Campbell, E.A.
Deposit date:2019-04-18
Release date:2019-08-28
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.26 Å)
Cite:Structural basis for transcription activation by Crl through tethering of sigmaSand RNA polymerase.
Proc.Natl.Acad.Sci.USA, 116, 2019
4X8K
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BU of 4x8k by Molmil
Mycobacterium tuberculosis RbpA-SID in complex with SigmaA domain 2
Descriptor: 1,2-ETHANEDIOL, RNA polymerase sigma factor SigA, RNA polymerase-binding protein RbpA, ...
Authors:Hubin, E.A, Flack, J.E, Tabib-Salazar, A, Paget, M.S, Darst, S.A, Campbell, E.A.
Deposit date:2014-12-10
Release date:2015-06-03
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.202 Å)
Cite:Structural, functional, and genetic analyses of the actinobacterial transcription factor RbpA.
Proc.Natl.Acad.Sci.USA, 112, 2015
4XLS
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BU of 4xls by Molmil
Crystal structure of T. aquaticus transcription initiation complex with CarD containing upstream fork promoter.
Descriptor: CarD-like transcriptional regulator, DNA (30-MER), DNA (5'-D(P*GP*CP*AP*CP*AP*AP*TP*TP*TP*AP*AP*CP*AP*CP*TP*TP*TP*TP*GP*TP*CP*AP*AP*G)-3'), ...
Authors:Bae, B, Darst, S.A.
Deposit date:2015-01-13
Release date:2015-09-23
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (4.01 Å)
Cite:CarD uses a minor groove wedge mechanism to stabilize the RNA polymerase open promoter complex.
Elife, 4, 2015
4XLR
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BU of 4xlr by Molmil
Crystal structure of T.aquaticus transcription initiation complex with CarD containing bubble promoter and RNA
Descriptor: CarD-like transcriptional regulator, DNA (48-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Bae, B, Darst, S.A.
Deposit date:2015-01-13
Release date:2015-09-23
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:CarD uses a minor groove wedge mechanism to stabilize the RNA polymerase open promoter complex.
Elife, 4, 2015
4XLN
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BU of 4xln by Molmil
Crystal structure of T. aquaticus transcription initiation complex containing bubble promoter and RNA
Descriptor: DNA (48-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Bae, B, Darst, S.A.
Deposit date:2015-01-13
Release date:2015-09-23
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structure of a bacterial RNA polymerase holoenzyme open promoter complex.
Elife, 4, 2015
4XAX
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BU of 4xax by Molmil
Crystal structure of Thermus thermophilus CarD in complex with the Thermus aquaticus RNA polymerase beta1 domain
Descriptor: 1,2-ETHANEDIOL, CarD, DNA-directed RNA polymerase subunit beta domain 1
Authors:Chen, J, Bae, B, Campbell, E.A, Darst, S.A.
Deposit date:2014-12-15
Release date:2015-09-16
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.404 Å)
Cite:CarD uses a minor groove wedge mechanism to stabilize the RNA polymerase open promoter complex.
Elife, 4, 2015
4XLQ
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BU of 4xlq by Molmil
Crystal structure of T.aquaticus transcription initiation complex containing upstream fork (-11 base-paired) promoter
Descriptor: DNA (26-MER), DNA (30-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Bae, B, Darst, S.A.
Deposit date:2015-01-13
Release date:2015-09-23
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (4.6 Å)
Cite:Structure of a bacterial RNA polymerase holoenzyme open promoter complex.
Elife, 4, 2015
4XSZ
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BU of 4xsz by Molmil
Crystal structure of CBR 9393 bound to Escherichia coli RNA polymerase holoenzyme
Descriptor: 4-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]-N-[2-(piperazin-1-yl)ethyl]-2-(trifluoromethyl)aniline, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Bae, B, Darst, S.A.
Deposit date:2015-01-22
Release date:2015-07-22
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.683 Å)
Cite:CBR antimicrobials inhibit RNA polymerase via at least two bridge-helix cap-mediated effects on nucleotide addition.
Proc.Natl.Acad.Sci.USA, 112, 2015
4XSX
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BU of 4xsx by Molmil
Crystal structure of CBR 703 bound to Escherichia coli RNA polymerase holoenzyme
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Bae, B, Darst, S.A.
Deposit date:2015-01-22
Release date:2015-07-22
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.708 Å)
Cite:CBR antimicrobials inhibit RNA polymerase via at least two bridge-helix cap-mediated effects on nucleotide addition.
Proc.Natl.Acad.Sci.USA, 112, 2015
4XLP
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BU of 4xlp by Molmil
Crystal structure of T.aquaticus transcription initiation complex containing upstream fork promoter
Descriptor: DNA (25-MER), DNA (30-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Bae, B, Darst, S.A.
Deposit date:2015-01-13
Release date:2015-09-23
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structure of a bacterial RNA polymerase holoenzyme open promoter complex.
Elife, 4, 2015
4XSY
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BU of 4xsy by Molmil
Crystal structure of CBR 9379 bound to Escherichia coli RNA polymerase holoenzyme
Descriptor: 3-{[(2,6-dichlorophenyl)carbamoyl]amino}-N-hydroxy-N'-phenyl-5-(trifluoromethyl)benzenecarboximidamide, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Bae, B, Darst, S.A.
Deposit date:2015-01-22
Release date:2015-07-22
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (4.007 Å)
Cite:CBR antimicrobials inhibit RNA polymerase via at least two bridge-helix cap-mediated effects on nucleotide addition.
Proc.Natl.Acad.Sci.USA, 112, 2015
3TBI
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BU of 3tbi by Molmil
Crystal structure of T4 gp33 bound to E. coli RNAP beta-flap domain
Descriptor: DNA-directed RNA polymerase subunit beta, RNA polymerase-associated protein Gp33
Authors:Twist, K.A.F, Campbell, E.A, Darst, S.A.
Deposit date:2011-08-06
Release date:2011-11-23
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of T4 gp33 bound to E. coli RNAP beta-flap domain
To be Published
3UGO
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BU of 3ugo by Molmil
Crystal structure of RNA-polymerase sigma subunit domain 2 complexed with -10 promoter element ssDNA oligo (TACAAT)
Descriptor: 5'-D(*TP*GP*TP*AP*CP*AP*AP*TP*GP*GP*G)-3', POTASSIUM ION, RNA polymerase sigma factor
Authors:Feklistov, A, Darst, S.A.
Deposit date:2011-11-02
Release date:2011-12-07
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.096 Å)
Cite:Structural basis for promoter-10 element recognition by the bacterial RNA polymerase sigma subunit.
Cell(Cambridge,Mass.), 147, 2011
3UGP
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BU of 3ugp by Molmil
Crystal structure of RNA-polymerase sigma subunit domain 2 complexed with -10 promoter element ssDNA oligo (TATAAT)
Descriptor: 5'-D(*TP*GP*TP*AP*TP*AP*AP*TP*GP*GP*G)-3', POTASSIUM ION, RNA polymerase sigma factor
Authors:Feklistov, A, Darst, S.A.
Deposit date:2011-11-02
Release date:2011-12-07
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.697 Å)
Cite:Structural basis for promoter-10 element recognition by the bacterial RNA polymerase sigma subunit.
Cell(Cambridge,Mass.), 147, 2011
1YNJ
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BU of 1ynj by Molmil
Taq RNA polymerase-Sorangicin complex
Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Campbell, E.A, Pavlova, O, Zenkin, N, Leon, F, Irschik, H, Jansen, R, Severinov, K, Darst, S.A.
Deposit date:2005-01-24
Release date:2005-03-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase
Embo J., 24, 2005
1ZPQ
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BU of 1zpq by Molmil
STRUCTURE OF BACTERIOPHAGE LAMBDA CII protein
Descriptor: Regulatory protein CII
Authors:Jain, D, Kim, Y, Maxwell, K.L, Beasley, S, Gussin, G.N, Edwards, A.M, Joachimiak, A, Darst, S.A, Midwest Center for Structural Genomics (MCSG)
Deposit date:2005-05-17
Release date:2005-08-23
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of Bacteriophage lambdacII and Its DNA Complex.
Mol.Cell, 19, 2005
1ZS4
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BU of 1zs4 by Molmil
Structure of bacteriophage lambda cII protein in complex with DNA
Descriptor: DNA - 27mer, Regulatory protein CII
Authors:Jain, D, Kim, Y, Maxwell, K.L, Beasley, S, Gussin, G.N, Edwards, A.M, Darst, S.A.
Deposit date:2005-05-23
Release date:2005-08-23
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of Bacteriophage lambdacII and Its DNA Complex.
Mol.Cell, 19, 2005
8E8M
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BU of 8e8m by Molmil
Mycobacterium tuberculosis RNAP paused elongation complex
Descriptor: DNA (54-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Delbeau, M, Darst, S.A, Campbell, E.A.
Deposit date:2022-08-25
Release date:2023-03-22
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (3.13 Å)
Cite:Structural and functional basis of the universal transcription factor NusG pro-pausing activity in Mycobacterium tuberculosis.
Mol.Cell, 83, 2023
8E74
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BU of 8e74 by Molmil
Mycobacterium tuberculosis RNAP paused elongation complex with NusG transcription factor
Descriptor: DNA (54-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Delbeau, M, Darst, S.A, Campbell, E.A.
Deposit date:2022-08-23
Release date:2023-03-22
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (2.94 Å)
Cite:Structural and functional basis of the universal transcription factor NusG pro-pausing activity in Mycobacterium tuberculosis.
Mol.Cell, 83, 2023
8E82
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BU of 8e82 by Molmil
Mycobacterium tuberculosis RNAP elongation complex with NusG transcription factor
Descriptor: DNA (54-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Delbeau, M, Darst, S.A, Campbell, E.A.
Deposit date:2022-08-25
Release date:2023-03-22
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:Structural and functional basis of the universal transcription factor NusG pro-pausing activity in Mycobacterium tuberculosis.
Mol.Cell, 83, 2023
8E79
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BU of 8e79 by Molmil
Mycobacterium tuberculosis RNAP paused elongation complex with Escherichia coli NusG transcription factor
Descriptor: DNA (54-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Delbeau, M, Darst, S.A, Campbell, E.A.
Deposit date:2022-08-23
Release date:2023-03-22
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (3.71 Å)
Cite:Structural and functional basis of the universal transcription factor NusG pro-pausing activity in Mycobacterium tuberculosis.
Mol.Cell, 83, 2023
8E95
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BU of 8e95 by Molmil
Mycobacterium tuberculosis RNAP elongation complex
Descriptor: DNA (25-MER), DNA (33-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Delbeau, M, Darst, S.A, Campbell, E.A.
Deposit date:2022-08-26
Release date:2023-03-22
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural and functional basis of the universal transcription factor NusG pro-pausing activity in Mycobacterium tuberculosis.
Mol.Cell, 83, 2023
1SIG
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BU of 1sig by Molmil
CRYSTAL STRUCTURE OF A SIGMA70 SUBUNIT FRAGMENT FROM ESCHERICHIA COLI RNA POLYMERASE
Descriptor: RNA POLYMERASE PRIMARY SIGMA FACTOR
Authors:Malhotra, A, Severinova, E, Darst, S.A.
Deposit date:1997-02-18
Release date:1997-05-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of a sigma 70 subunit fragment from E. coli RNA polymerase.
Cell(Cambridge,Mass.), 87, 1996
2GHO
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BU of 2gho by Molmil
Recombinant Thermus aquaticus RNA polymerase for Structural Studies
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta',DNA-directed RNA polymerase subunit beta'
Authors:Lamour, V, Darst, S.A.
Deposit date:2006-03-27
Release date:2006-05-23
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (5 Å)
Cite:Recombinant Thermus aquaticus RNA Polymerase for Structural Studies.
J.Mol.Biol., 359, 2006
2ETN
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BU of 2etn by Molmil
Crystal structure of Thermus aquaticus Gfh1
Descriptor: anti-cleavage anti-GreA transcription factor Gfh1
Authors:Lamour, V, Hogan, B.P, Erie, D.A, Darst, S.A.
Deposit date:2005-10-27
Release date:2006-02-14
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystal structure of Thermus aquaticus Gfh1, a Gre-factor paralog that inhibits rather than stimulates transcript cleavage.
J.Mol.Biol., 356, 2006

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數據於2024-10-30公開中

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