7S1K
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![BU of 7s1k by Molmil](/molmil-images/mine/7s1k) | Cfr-modified Escherichia coli stalled ribosome with antibiotic radezolid | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Tsai, K, Stojkovic, V, Lee, D.J, Young, I.D, Szal, T, Vazquez-Laslop, N, Mankin, A.S, Fraser, J.S, Galonic Fujimori, D. | Deposit date: | 2021-09-02 | Release date: | 2022-01-19 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.42 Å) | Cite: | Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics. Nat.Struct.Mol.Biol., 29, 2022
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5AMM
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![BU of 5amm by Molmil](/molmil-images/mine/5amm) | Structure of Leishmania major peroxidase D211N mutant | Descriptor: | ASCORBATE PEROXIDASE, CALCIUM ION, POTASSIUM ION, ... | Authors: | Chreifi, G, Fields, J.B, Hollingsworth, S.A, Heyden, M, Arce, A.P, Magana-Garcia, H.I, Poulos, T.L, Tobias, D.J. | Deposit date: | 2015-03-11 | Release date: | 2015-12-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | "Bind and Crawl" Association Mechanism of Leishmania Major Peroxidase and Cytochrome C Revealed by Brownian and Molecular Dynamics Simulations. Biochemistry, 54, 2015
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7QWT
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![BU of 7qwt by Molmil](/molmil-images/mine/7qwt) | Rieske non-heme iron monooxygenase for guaiacol O-demethylation | Descriptor: | FE (III) ION, FE2/S2 (INORGANIC) CLUSTER, Rieske (2Fe-2S) domain protein | Authors: | Hinchen, D.J, Zahn, M, Bleem, A, Beckham, G.T, McGeehan, J.E. | Deposit date: | 2022-01-25 | Release date: | 2022-06-01 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (3.712 Å) | Cite: | Discovery, characterization, and metabolic engineering of Rieske non-heme iron monooxygenases for guaiacol O-demethylation Chem Catal, 2022
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5BU6
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![BU of 5bu6 by Molmil](/molmil-images/mine/5bu6) | Structure of BpsB deaceylase domain from Bordetella bronchiseptica | Descriptor: | 1,2-ETHANEDIOL, BpsB (PgaB), Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase, ... | Authors: | Little, D.J, Bamford, N.C, Howell, P.L. | Deposit date: | 2015-06-03 | Release date: | 2015-07-29 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.951 Å) | Cite: | The Protein BpsB Is a Poly-beta-1,6-N-acetyl-d-glucosamine Deacetylase Required for Biofilm Formation in Bordetella bronchiseptica. J.Biol.Chem., 290, 2015
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7SCI
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![BU of 7sci by Molmil](/molmil-images/mine/7sci) | AM0627 metallopeptidase from Akkermansia muciniphila | Descriptor: | CHLORIDE ION, FORMIC ACID, Peptidase M60 domain-containing protein, ... | Authors: | Fernandez, D, Bertozzi, C.R, Shon, D.J. | Deposit date: | 2021-09-28 | Release date: | 2022-04-27 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure-guided mutagenesis of a mucin-selective metalloprotease from Akkermansia muciniphila alters substrate preferences. J.Biol.Chem., 298, 2022
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5AMN
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![BU of 5amn by Molmil](/molmil-images/mine/5amn) | The Discovery of 2-Substituted Phenol Quinazolines as Potent and Selective RET Kinase Inhibitors | Descriptor: | 4-[3-HYDROXYANILINO]-6,7-DIMETHOXYQUINAZOLINE, FORMIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET | Authors: | Newton, R, Bowler, K, Burns, E.M, Chapman, P, Fairweather, E, Fritzl, S, Goldberg, K, Hamilton, N.M, Holt, S.V, Hopkins, G.V, Jones, S.D, Jordan, A.M, Lyons, A, McDonald, N.Q, Maguire, L.A, Mould, D.P, Purkiss, A.G, Small, H.F, Stowell, A, Thomson, G.J, Waddell, I.D, Waszkowycz, B, Watson, A.J, Ogilvie, D.J. | Deposit date: | 2015-03-11 | Release date: | 2016-02-17 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity. Eur J Med Chem, 112, 2016
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5BS7
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![BU of 5bs7 by Molmil](/molmil-images/mine/5bs7) | Structure of histone H3/H4 in complex with Spt2 | Descriptor: | Histone H3.2, Histone H4, Protein SPT2 homolog, ... | Authors: | Chen, S, Patel, D.J. | Deposit date: | 2015-06-01 | Release date: | 2015-07-08 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structure-function studies of histone H3/H4 tetramer maintenance during transcription by chaperone Spt2. Genes Dev., 29, 2015
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7SHP
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![BU of 7shp by Molmil](/molmil-images/mine/7shp) | Crystal structure of hSTING in complex with c[2',3'-(ribo-2'-G, xylo-3'-A)-MP](RJ244) | Descriptor: | (2S,5R,7R,8R,10S,12aR,14R,15R,15aR,16R)-7-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-2,10,15,16-tetrahydroxyoctahydro-2H,10H,12H-5,8-methano-2lambda~5~,10lambda~5~-furo[3,2-l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione, Stimulator of interferon genes protein | Authors: | Xie, W, Lama, L, Yang, X.J, Kuryavyi, V, Nudelman, I, Glickman, J.F, Jones, R.A, Tuschl, T, Patel, D.J. | Deposit date: | 2021-10-11 | Release date: | 2022-10-19 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Arabinose- and xylose-modified analogs of 2',3'-cGAMP act as STING agonists. Cell Chem Biol, 2023
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5BNV
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7SHO
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![BU of 7sho by Molmil](/molmil-images/mine/7sho) | Crystal structure of hSTING in complex with c[2',3'-(ara-2'-G, ribo-3'-A)-MP] (RJ242) | Descriptor: | (2R,5R,7R,8S,10R,12aR,14R,15R,15aS,16R)-7-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-2,10,15,16-tetrahydroxyoctahydro-2H,10H,12H-5,8-methano-2lambda~5~,10lambda~5~-furo[3,2-l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione, Stimulator of interferon genes protein | Authors: | Xie, W, Lama, L, Yang, X.J, Kuryavyi, V, Nudelman, I, Glickman, J.F, Jones, R.A, Tuschl, T, Patel, D.J. | Deposit date: | 2021-10-10 | Release date: | 2022-10-12 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Arabinose- and xylose-modified analogs of 2',3'-cGAMP act as STING agonists. Cell Chem Biol, 2023
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7S7P
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7RYW
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![BU of 7ryw by Molmil](/molmil-images/mine/7ryw) | Crystal structure of Ferritin grown by the microbatch method in the presence of Agarose | Descriptor: | CADMIUM ION, Ferritin light chain, SULFATE ION | Authors: | Aditya, S, Priyadharshine, R, Maham, I, Miller, D.J, Stojanoff, V. | Deposit date: | 2021-08-26 | Release date: | 2022-11-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Crystal structure of Ferritin grown by microbatch method in the presence of agarose To Be Published
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4ZZE
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![BU of 4zze by Molmil](/molmil-images/mine/4zze) | Raffinose and panose binding protein from Bifidobacterium animalis subsp. lactis Bl-04, bound with panose | Descriptor: | CHLORIDE ION, MAGNESIUM ION, Sugar binding protein of ABC transporter system, ... | Authors: | Fredslund, F, Ejby, M, Andersen, J.M, Slotboom, D.J, Hachem, M.A. | Deposit date: | 2015-05-22 | Release date: | 2016-06-29 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | An ATP Binding Cassette Transporter Mediates the Uptake of alpha-(1,6)-Linked Dietary Oligosaccharides in Bifidobacterium and Correlates with Competitive Growth on These Substrates. J. Biol. Chem., 291, 2016
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5A59
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![BU of 5a59 by Molmil](/molmil-images/mine/5a59) | The structure of GH101 E796Q mutant from Streptococcus pneumoniae TIGR4 in complex with T-antigen | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, CITRIC ACID, ... | Authors: | Gregg, K.J, Suits, M.D.L, Deng, L, Vocadlo, D.J, Boraston, A.B. | Deposit date: | 2015-06-16 | Release date: | 2015-09-02 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural Analysis of a Family 101 Glycoside Hydrolase in Complex with Carbohydrates Reveals Insights Into its Mechanism. J.Biol.Chem., 290, 2015
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5C7Z
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5C3F
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![BU of 5c3f by Molmil](/molmil-images/mine/5c3f) | Crystal structure of Mcl-1 bound to BID-MM | Descriptor: | BID-MM, GLYCEROL, Induced myeloid leukemia cell differentiation protein Mcl-1 | Authors: | Miles, J.A, Yeo, D.J, Rowell, P, Rodriguez-Marin, S, Pask, C.M, Warriner, S.L, Edwards, T.A, Wilson, A.J. | Deposit date: | 2015-06-17 | Release date: | 2016-04-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.43 Å) | Cite: | Hydrocarbon constrained peptides - understanding preorganisation and binding affinity. Chem Sci, 7, 2016
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5BSA
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![BU of 5bsa by Molmil](/molmil-images/mine/5bsa) | Structure of histone H3/H4 in complex with Spt2 | Descriptor: | Histone H3.2, Histone H4, Protein SPT2 homolog | Authors: | Chen, S, Patel, D.J. | Deposit date: | 2015-06-01 | Release date: | 2015-07-08 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (4.611 Å) | Cite: | Structure-function studies of histone H3/H4 tetramer maintenance during transcription by chaperone Spt2. Genes Dev., 29, 2015
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5C3G
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![BU of 5c3g by Molmil](/molmil-images/mine/5c3g) | Crystal structure of Bcl-xl bound to BIM-MM | Descriptor: | Bcl-2-like protein 1,Bcl-2-like protein 1, Bcl-2-like protein 11 | Authors: | Miles, J.A, Yeo, D.J, Rowell, P, Rodriguez-Marin, S, Pask, C.M, Warriner, S.L, Edwards, T.A, Wilson, A.J. | Deposit date: | 2015-06-17 | Release date: | 2016-04-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Hydrocarbon constrained peptides - understanding preorganisation and binding affinity. Chem Sci, 7, 2016
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5D0Y
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5D6T
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![BU of 5d6t by Molmil](/molmil-images/mine/5d6t) | Crystal Structure of Aspergillus clavatus Sph3 in complex with GalNAc | Descriptor: | 2-acetamido-2-deoxy-beta-D-galactopyranose, CHLORIDE ION, SPHERULIN-4, ... | Authors: | Bamford, N.C, Little, D.J, Howell, P.L. | Deposit date: | 2015-08-12 | Release date: | 2015-09-16 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Sph3 Is a Glycoside Hydrolase Required for the Biosynthesis of Galactosaminogalactan in Aspergillus fumigatus. J.Biol.Chem., 290, 2015
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5A3F
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![BU of 5a3f by Molmil](/molmil-images/mine/5a3f) | Crystal structure of the dynamin tetramer | Descriptor: | DYNAMIN 3 | Authors: | Reubold, T.F, Faelber, K, Plattner, N, Posor, Y, Branz, K, Curth, U, Schlegel, J, Anand, R, Manstein, D.J, Noe, F, Haucke, V, Daumke, O, Eschenburg, S. | Deposit date: | 2015-05-29 | Release date: | 2015-08-26 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Crystal Structure of the Dynamin Tetramer Nature, 525, 2015
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5A5V
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![BU of 5a5v by Molmil](/molmil-images/mine/5a5v) | A complex of the synthetic siderophore analogue Fe(III)-6-LICAM with the CeuE periplasmic protein from Campylobacter jejuni | Descriptor: | ENTEROCHELIN UPTAKE PERIPLASMIC BINDING PROTEIN, FE (III) ION, N,N'-hexane-1,4-diylbis(2,3-dihydroxybenzamide) | Authors: | Blagova, E, Hughes, A, Moroz, O.V, Raines, D.J, Wilde, E.J, Turkenburg, J.P, Duhme-Klair, A.-K, Wilson, K.S. | Deposit date: | 2015-06-22 | Release date: | 2016-07-06 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Interactions of the periplasmic binding protein CeuE with Fe(III) n-LICAM(4-) siderophore analogues of varied linker length. Sci Rep, 7, 2017
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4MQU
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![BU of 4mqu by Molmil](/molmil-images/mine/4mqu) | Human GKRP complexed to AMG-3969 and S6P | Descriptor: | 2-{4-[(2S)-4-[(6-aminopyridin-3-yl)sulfonyl]-2-(prop-1-yn-1-yl)piperazin-1-yl]phenyl}-1,1,1,3,3,3-hexafluoropropan-2-ol, D-SORBITOL-6-PHOSPHATE, GLYCEROL, ... | Authors: | St Jean, D.J, Ashton, K.S, Bartberger, M.D, Chen, J, Chmait, S, Cupples, R, Galbreath, E, Helmering, J, Jordan, S.R, Liu, L. | Deposit date: | 2013-09-16 | Release date: | 2014-05-07 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles. J.Med.Chem., 57, 2014
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5DDP
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![BU of 5ddp by Molmil](/molmil-images/mine/5ddp) | L-glutamine riboswitch bound with L-glutamine | Descriptor: | GLUTAMINE, MAGNESIUM ION, RNA (61-MER), ... | Authors: | Ren, A, Patel, D.J. | Deposit date: | 2015-08-25 | Release date: | 2015-12-23 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.302 Å) | Cite: | Structural and Dynamic Basis for Low-Affinity, High-Selectivity Binding of L-Glutamine by the Glutamine Riboswitch. Cell Rep, 13, 2015
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5CYJ
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![BU of 5cyj by Molmil](/molmil-images/mine/5cyj) | X-ray structure of human RBPMS | Descriptor: | RNA-binding protein with multiple splicing | Authors: | Teplova, M, Farazi, T.A, Patel, D.J. | Deposit date: | 2015-07-30 | Release date: | 2015-09-30 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Structural basis underlying CAC RNA recognition by the RRM domain of dimeric RNA-binding protein RBPMS. Q. Rev. Biophys., 49, 2016
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