6MRK
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2GMO
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![BU of 2gmo by Molmil](/molmil-images/mine/2gmo) | NMR-structure of an independently folded C-terminal domain of influenza polymerase subunit PB2 | 分子名称: | Polymerase basic protein 2 | 著者 | Boudet, J, Tarendeau, F, Guilligay, D, Mas, P, Bougault, C.M, Cusack, S, Simorre, J.-P, Hart, D.J. | 登録日 | 2006-04-07 | 公開日 | 2007-02-27 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit. Nat.Struct.Mol.Biol., 14, 2007
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2H0S
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6MJX
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![BU of 6mjx by Molmil](/molmil-images/mine/6mjx) | human cGAS catalytic domain bound with cGAMP | 分子名称: | Cyclic GMP-AMP synthase, ZINC ION, cGAMP | 著者 | Lama, L, Adura, C, Xie, W, Tomita, D, Kamei, T, Kuryavyi, V, Gogakos, T, Steinberg, J.I, Miller, M, Ramos-Espiritu, L, Asano, Y, Hashizume, S, Aida, J, Imaeda, T, Okamoto, R, Jennings, A.J, Michinom, M, Kuroita, T, Stamford, A, Gao, P, Meinke, P, Glickman, J.F, Patel, D.J, Tuschl, T. | 登録日 | 2018-09-23 | 公開日 | 2019-05-29 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression. Nat Commun, 10, 2019
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2H4U
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![BU of 2h4u by Molmil](/molmil-images/mine/2h4u) | Crystal Structure of Human Thioesterase Superfamily Member 2 | 分子名称: | Thioesterase superfamily member 2 | 著者 | Ogg, D.J, Uppenberg, J, Arrowsmith, C, Berglund, H, Edwards, A, Ehn, M, Grasslund, S, Flodin, S, Hammerstrom, M, Hogbom, M, Holmberg-Schiavone, L, Kotenyova, T, Nilsson-Ehle, P, Nordlund, P, Nyman, T, Persson, C, Sagemark, J, Sundstrom, M, Thorsell, A.-G, Weigelt, J, Hallberg, M, Structural Genomics Consortium (SGC) | 登録日 | 2006-05-25 | 公開日 | 2006-06-20 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The crystal structure of human thioesterase superfamily member 2 To be Published
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2GJX
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![BU of 2gjx by Molmil](/molmil-images/mine/2gjx) | Crystallographic structure of human beta-Hexosaminidase A | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-hexosaminidase alpha chain, ... | 著者 | Lemieux, M.J, Mark, B.L, Cherney, M.M, Withers, S.G, Mahuran, D.J, James, M.N.G. | 登録日 | 2006-03-31 | 公開日 | 2006-06-20 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystallographic structure of human beta-Hexosaminidase A: Interpretation of Tay-Sachs Mutations and Loss
of GM2 Ganglioside Hydrolysis J.Mol.Biol., 359, 2006
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2VGG
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![BU of 2vgg by Molmil](/molmil-images/mine/2vgg) | HUMAN ERYTHROCYTE PYRUVATE KINASE: R479H MUTANT | 分子名称: | 1,6-di-O-phosphono-beta-D-fructofuranose, 2-PHOSPHOGLYCOLIC ACID, MANGANESE (II) ION, ... | 著者 | Valentini, G, Chiarelli, L.R, Fortin, R, Dolzan, M, Galizzi, A, Abraham, D.J, Wang, C, Bianchi, P, Zanella, A, Mattevi, A. | 登録日 | 2007-11-13 | 公開日 | 2007-11-20 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | 主引用文献 | Structure and Function of Human Erythrocyte Pyruvate Kinase. Molecular Basis of Nonspherocytic Hemolytic Anemia. J.Biol.Chem., 277, 2002
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2CEY
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![BU of 2cey by Molmil](/molmil-images/mine/2cey) | Apo Structure of SiaP | 分子名称: | PROTEIN HI0146, ZINC ION | 著者 | Muller, A, Severi, E, Mulligan, C, Watts, A.G, Kelly, D.J, Wilson, K.S, Wilkinson, A.J, Thomas, G.H. | 登録日 | 2006-02-11 | 公開日 | 2006-05-15 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Conservation of Structure and Mechanism in Primary and Secondary Transporters Exemplified by Siap, a Sialic Acid Binding Virulence Factor from Haemophilus Influenzae J.Biol.Chem., 281, 2006
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2CCF
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![BU of 2ccf by Molmil](/molmil-images/mine/2ccf) | Antiparallel Configuration of pLI E20S | 分子名称: | General control protein GCN4 | 著者 | Yadav, M.K, Leman, L.J, Price, D.J, Brooks 3rd, C.L, Stout, C.D, Ghadiri, M.R. | 登録日 | 2006-01-16 | 公開日 | 2006-04-06 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Coiled coils at the edge of configurational heterogeneity. Structural analyses of parallel and antiparallel homotetrameric coiled coils reveal configurational sensitivity to a single solvent-exposed amino acid substitution. Biochemistry, 45, 2006
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2CAY
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![BU of 2cay by Molmil](/molmil-images/mine/2cay) | Vps36 N-terminal PH domain | 分子名称: | SULFATE ION, VACUOLAR PROTEIN SORTING PROTEIN 36 | 著者 | Teo, H, Williams, R.L, Perisic, O, Gill, D.J. | 登録日 | 2005-12-23 | 公開日 | 2006-04-07 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Escrt-I Core and Escrt-II Glue Domain Structures Reveal Role for Glue in Linking to Escrt-I and Membranes. Cell(Cambridge,Mass.), 125, 2006
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2CAZ
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![BU of 2caz by Molmil](/molmil-images/mine/2caz) | ESCRT-I core | 分子名称: | PROTEIN SRN2, SUPPRESSOR PROTEIN STP22 OF TEMPERATURE-SENSITIVE ALPHA-FACTOR RECEPTOR AND ARGININE PERMEASE, VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS28 | 著者 | Gill, D.J, Teo, H, Sun, J, Perisic, O, Veprintsev, D.B, Vallis, Y, Emr, S.D, Williams, R.L. | 登録日 | 2005-12-23 | 公開日 | 2006-04-07 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Escrt-I Core and Escrt-II Glue Domain Structures Reveal Role for Glue in Linking to Escrt-I and Membranes. Cell(Cambridge,Mass.), 125, 2006
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2VGF
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![BU of 2vgf by Molmil](/molmil-images/mine/2vgf) | HUMAN ERYTHROCYTE PYRUVATE KINASE: T384M mutant | 分子名称: | 1,6-di-O-phosphono-beta-D-fructofuranose, 2-PHOSPHOGLYCOLIC ACID, MANGANESE (II) ION, ... | 著者 | Valentini, G, Chiarelli, L.R, Fortin, R, Dolzan, M, Galizzi, A, Abraham, D.J, Wang, C, Bianchi, P, Zanella, A, Mattevi, A. | 登録日 | 2007-11-12 | 公開日 | 2007-11-20 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structure and Function of Human Erythrocyte Pyruvate Kinase. Molecular Basis of Nonspherocytic Hemolytic Anemia. J.Biol.Chem., 277, 2002
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6MJU
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![BU of 6mju by Molmil](/molmil-images/mine/6mju) | human cGAS catalytic domain bound with the inhibitor G108 | 分子名称: | 1-[6,7-dichloro-9-(1H-pyrazol-4-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethan-1-one, Cyclic GMP-AMP synthase, ZINC ION | 著者 | Lama, L, Adura, C, Xie, W, Tomita, D, Kamei, T, Kuryavyi, V, Gogakos, T, Steinberg, J.I, Miller, M, Ramos-Espiritu, L, Asano, Y, Hashizume, S, Aida, J, Imaeda, T, Okamoto, R, Jennings, A.J, Michinom, M, Kuroita, T, Stamford, A, Gao, P, Meinke, P, Glickman, J.F, Patel, D.J, Tuschl, T. | 登録日 | 2018-09-22 | 公開日 | 2019-05-29 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression. Nat Commun, 10, 2019
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6MUU
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![BU of 6muu by Molmil](/molmil-images/mine/6muu) | Cryo-EM structure of Csm-crRNA binary complex in type III-A CRISPR-Cas system | 分子名称: | RNA (25-MER), Uncharacterized protein Csm1, Uncharacterized protein Csm2, ... | 著者 | Jia, N, Wang, C, Eng, E.T, Patel, D.J. | 登録日 | 2018-10-23 | 公開日 | 2018-12-19 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity. Mol. Cell, 73, 2019
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6MVP
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![BU of 6mvp by Molmil](/molmil-images/mine/6mvp) | HCV NS5B 1b N316 bound to Compound 18 | 分子名称: | (4-{[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl](methylsulfonyl)amino}phenyl)boronic acid, Genome polyprotein | 著者 | Williams, S.P, Kahler, K, Price, D.J, Peat, A.J. | 登録日 | 2018-10-26 | 公開日 | 2019-09-04 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Design of N-Benzoxaborole Benzofuran GSK8175-Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor. J.Med.Chem., 62, 2019
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6MVO
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![BU of 6mvo by Molmil](/molmil-images/mine/6mvo) | HCV NS5B 1A Y316 bound to Compound 49 | 分子名称: | 6-[(7-chloro-1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)(methylsulfonyl)amino]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide, RNA-directed RNA polymerase, SULFATE ION | 著者 | Williams, S.P, Kahler, K, Price, D.J, Peat, A.J. | 登録日 | 2018-10-26 | 公開日 | 2019-09-04 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Design of N-Benzoxaborole Benzofuran GSK8175-Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor. J.Med.Chem., 62, 2019
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2H0W
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2VGB
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![BU of 2vgb by Molmil](/molmil-images/mine/2vgb) | HUMAN ERYTHROCYTE PYRUVATE KINASE | 分子名称: | 1,6-di-O-phosphono-beta-D-fructofuranose, 2-PHOSPHOGLYCOLIC ACID, MANGANESE (II) ION, ... | 著者 | Valentini, G, Chiarelli, L, Fortin, R, Dolzan, M, Galizzi, A, Abraham, D.J, Wang, C, Bianchi, P, Zanella, A, Mattevi, A. | 登録日 | 2007-11-12 | 公開日 | 2007-11-20 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.73 Å) | 主引用文献 | Structure and Function of Human Erythrocyte Pyruvate Kinase. Molecular Basis of Nonspherocytic Hemolytic Anemia. J.Biol.Chem., 277, 2002
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2H6N
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![BU of 2h6n by Molmil](/molmil-images/mine/2h6n) | Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex | 分子名称: | Histone H3 K4-Me2 9-residue peptide, WD-repeat protein 5 | 著者 | Ruthenburg, A.J, Wang, W.-K, Graybosch, D.M, Li, H, Allis, C.D, Patel, D.J, Verdine, G.L. | 登録日 | 2006-05-31 | 公開日 | 2006-07-04 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex. Nat.Struct.Mol.Biol., 13, 2006
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2VE9
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![BU of 2ve9 by Molmil](/molmil-images/mine/2ve9) | Xray structure of KOPS bound gamma domain of FtsK (P. aeruginosa) | 分子名称: | 5'-D(*AP*CP*CP*AP*GP*GP*GP*CP*AP*GP *GP*GP*CP*GP*AP*C)-3', 5'-D(*GP*TP*CP*GP*CP*CP*CP*TP*GP*CP *CP*CP*TP*GP*GP*T)-3', DNA TRANSLOCASE FTSK, ... | 著者 | Lowe, J, Allen, M.D, Sherratt, D.J. | 登録日 | 2007-10-17 | 公開日 | 2008-09-09 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Molecular Mechanism of Sequence-Directed DNA Loading and Translocation by Ftsk. Mol.Cell, 31, 2008
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2VAH
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![BU of 2vah by Molmil](/molmil-images/mine/2vah) | Solution structure of a B-DNA hairpin at low pressure. | 分子名称: | 5'-D(*AP*GP*GP*AP*TP*CP*CP*TP*UP*TP *TP*GP*GP*AP*TP*CP*CP*T)-3' | 著者 | Williamson, M.P, Wilton, D.J, Ghosh, M, Chary, K.V.A, Akasaka, K. | 登録日 | 2007-08-31 | 公開日 | 2007-09-11 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural Change in a B-DNA Helix with Hydrostatic Pressure Nucleic Acids Res., 36, 2008
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2CEX
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![BU of 2cex by Molmil](/molmil-images/mine/2cex) | Structure of a sialic acid binding protein (SiaP) in the presence of the sialic acid acid analogue Neu5Ac2en | 分子名称: | 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, GLYCEROL, PROTEIN HI0146, ... | 著者 | Muller, A, Severi, E, Mulligan, C, Watts, A.G, Kelly, D.J, Wilson, K.S, Wilkinson, A.J, Thomas, G.H. | 登録日 | 2006-02-10 | 公開日 | 2006-05-15 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Conservation of Structure and Mechanism in Primary and Secondary Transporters Exemplified by Siap, a Sialic Acid Binding Virulence Factor from Haemophilus Influenzae J.Biol.Chem., 281, 2006
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6MVK
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![BU of 6mvk by Molmil](/molmil-images/mine/6mvk) | HCV NS5B 1b N316 bound to Compound 18 | 分子名称: | (4-{(4S)-3-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]-2-oxo-1,3-oxazolidin-4-yl}-2-fluorophenyl)boronic acid, HCV Polymerase | 著者 | Williams, S.P, Kahler, K, Price, D.J, Peat, A.J. | 登録日 | 2018-10-26 | 公開日 | 2019-09-04 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Design of N-Benzoxaborole Benzofuran GSK8175-Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor. J.Med.Chem., 62, 2019
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2PMD
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![BU of 2pmd by Molmil](/molmil-images/mine/2pmd) | The structures of aIF2gamma subunit from the archaeon Sulfolobus solfataricus in the GDP-bound form. | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, PYROPHOSPHATE, ... | 著者 | Nikonov, O.S, Stolboushkina, E.A, Nikulin, A.D, Hasenohrl, D, Blaesi, U, Manstein, D.J, Fedorov, R.V, Garber, M.B, Nikonov, S.V. | 登録日 | 2007-04-21 | 公開日 | 2007-11-06 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | New Insights into the Interactions of the Translation Initiation Factor 2 from Archaea with Guanine Nucleotides and Initiator tRNA. J.Mol.Biol., 373, 2007
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2VEO
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![BU of 2veo by Molmil](/molmil-images/mine/2veo) | X-ray structure of Candida antarctica lipase A in its closed state. | 分子名称: | GLYCEROL, LIPASE A, TETRAETHYLENE GLYCOL, ... | 著者 | Ericsson, D.J, Kasrayan, A, Johansson, P, Bergfors, T, Sandstrom, A.G, Backvall, J.E, Mowbray, S.L. | 登録日 | 2007-10-25 | 公開日 | 2007-11-06 | 最終更新日 | 2015-04-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | X-Ray Structure of Candida Antarctica Lipase a Shows a Novel Lid Structure and a Likely Mode of Interfacial Activation. J.Mol.Biol., 376, 2008
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