6MVK
HCV NS5B 1b N316 bound to Compound 18
Summary for 6MVK
Entry DOI | 10.2210/pdb6mvk/pdb |
Related | 6MVO 6MVP 6MVQ |
Descriptor | HCV Polymerase, (4-{(4S)-3-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]-2-oxo-1,3-oxazolidin-4-yl}-2-fluorophenyl)boronic acid (3 entities in total) |
Functional Keywords | hepatitus c, ns5b, viral protein |
Biological source | Hepatitis C virus subtype 1b |
Total number of polymer chains | 2 |
Total formula weight | 126015.75 |
Authors | Williams, S.P.,Kahler, K.,Price, D.J.,Peat, A.J. (deposition date: 2018-10-26, release date: 2019-09-04, Last modification date: 2024-03-13) |
Primary citation | Chong, P.Y.,Shotwell, J.B.,Miller, J.,Price, D.J.,Maynard, A.,Voitenleitner, C.,Mathis, A.,Williams, S.,Pouliot, J.J.,Creech, K.,Wang, F.,Fang, J.,Zhang, H.,Tai, V.W.,Turner, E.,Kahler, K.M.,Crosby, R.,Peat, A.J. Design of N-Benzoxaborole Benzofuran GSK8175-Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor. J.Med.Chem., 62:3254-3267, 2019 Cited by PubMed: 30763090DOI: 10.1021/acs.jmedchem.8b01719 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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