407D
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![BU of 407d by Molmil](/molmil-images/mine/407d) | STRUCTURAL BASIS FOR RECOGNITION OF A-T AND T-A BASE PAIRS IN THE MINOR GROOVE OF B-DNA | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DNA (5'-D(*CP*CP*AP*GP*TP*AP*CP*TP*GP*G)-3'), ~{N}-[5-[[5-[[5-[[3-[3-(dimethylamino)propylamino]-3-oxidanylidene-propyl]carbamoyl]-1-methyl-pyrrol-3-yl]carbamoyl]-1-methyl-pyrrol-3-yl]carbamoyl]-1-methyl-4-oxidanyl-pyrrol-3-yl]-1-methyl-imidazole-2-carboxamide | Authors: | Rees, D.C. | Deposit date: | 1998-06-24 | Release date: | 1998-10-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA. Science, 282, 1998
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5V83
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![BU of 5v83 by Molmil](/molmil-images/mine/5v83) | Structure of DCN1 bound to NAcM-HIT | Descriptor: | Lysozyme,DCN1-like protein 1 chimera, N-(1-benzylpiperidin-4-yl)-N'-[3-(trifluoromethyl)phenyl]urea | Authors: | Guy, R.K, Schulman, B.A, Scott, D.C, Hammill, J.T. | Deposit date: | 2017-03-21 | Release date: | 2017-05-24 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.002 Å) | Cite: | Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase. Nat. Chem. Biol., 13, 2017
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3UUX
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![BU of 3uux by Molmil](/molmil-images/mine/3uux) | Crystal structure of yeast Fis1 in complex with Mdv1 fragment containing N-terminal extension and coiled coil domains | Descriptor: | Mitochondria fission 1 protein, Mitochondrial division protein 1 | Authors: | Zhang, Y, Chan, N.C, Gristick, H, Chan, D.C. | Deposit date: | 2011-11-28 | Release date: | 2012-02-08 | Last modified: | 2012-04-25 | Method: | X-RAY DIFFRACTION (3.9 Å) | Cite: | Crystal structure of mitochondrial fission complex reveals scaffolding function for mitochondrial division 1 (mdv1) coiled coil. J.Biol.Chem., 287, 2012
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5UWB
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![BU of 5uwb by Molmil](/molmil-images/mine/5uwb) | |
4OAI
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![BU of 4oai by Molmil](/molmil-images/mine/4oai) | |
5U5N
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![BU of 5u5n by Molmil](/molmil-images/mine/5u5n) | |
4TKU
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![BU of 4tku by Molmil](/molmil-images/mine/4tku) | Reactivated Nitrogenase MoFe-protein from A. vinelandii | Descriptor: | 3-HYDROXY-3-CARBOXY-ADIPIC ACID, CHLORIDE ION, FE (II) ION, ... | Authors: | Spatzal, T, Perez, K, Einsle, O, Howard, J.B, Rees, D.C. | Deposit date: | 2014-05-27 | Release date: | 2014-10-01 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.43 Å) | Cite: | Ligand binding to the FeMo-cofactor: structures of CO-bound and reactivated nitrogenase. Science, 345, 2014
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3WQL
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![BU of 3wql by Molmil](/molmil-images/mine/3wql) | Crystal structure of Rv3378c with Mg2+ and PPi | Descriptor: | Diterpene synthase, MAGNESIUM ION | Authors: | Chan, H.C, Feng, X, Ko, T.P, Huang, C.H, Hu, Y, Zheng, Y, Bogue, S, Nakano, C, Hoshino, T, Zhang, L, Lv, P, Liu, W, Crick, D.C, Liang, P.H, Wang, A.H, Oldfield, E, Guo, R.T. | Deposit date: | 2014-01-28 | Release date: | 2014-02-19 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase from Mycobacterium tuberculosis. J.Am.Chem.Soc., 136, 2014
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4TKV
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![BU of 4tkv by Molmil](/molmil-images/mine/4tkv) | CO-bound Nitrogenase MoFe-protein from A. vinelandii | Descriptor: | 3-HYDROXY-3-CARBOXY-ADIPIC ACID, CARBON MONOXIDE, FE (II) ION, ... | Authors: | Spatzal, T, Perez, K, Einsle, O, Howard, J.B, Rees, D.C. | Deposit date: | 2014-05-28 | Release date: | 2014-10-01 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Ligand binding to the FeMo-cofactor: structures of CO-bound and reactivated nitrogenase. Science, 345, 2014
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5UVN
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4TN3
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![BU of 4tn3 by Molmil](/molmil-images/mine/4tn3) | Structure of the BBox-Coiled-coil region of Rhesus Trim5alpha | Descriptor: | TRIM5/cyclophilin A fusion protein/T4 Lysozyme chimera, ZINC ION | Authors: | Kirkpatrick, J.J, Stoye, J.P, Taylor, I.A, Goldstone, D.C. | Deposit date: | 2014-06-03 | Release date: | 2014-07-16 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.1989 Å) | Cite: | Structural studies of postentry restriction factors reveal antiparallel dimers that enable avid binding to the HIV-1 capsid lattice. Proc.Natl.Acad.Sci.USA, 111, 2014
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5UFW
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![BU of 5ufw by Molmil](/molmil-images/mine/5ufw) | Estrogen Receptor Alpha Ligand Binding Domain in Complex with OP1154 | Descriptor: | (2S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3S)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-2H-1-benzopyran-7-ol, Estrogen receptor | Authors: | Fanning, S.W, Hodges-Gallagher, L, Myles, D.C, Sun, R, Fowler, C.E, Green, B.D, Harmon, C.L, Greene, G.L, Kushner, P.J. | Deposit date: | 2017-01-06 | Release date: | 2018-01-10 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.583 Å) | Cite: | Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity. Nat Commun, 9, 2018
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5UGJ
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4PKE
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![BU of 4pke by Molmil](/molmil-images/mine/4pke) | The structure of a conserved Piezo channel domain reveals a novel beta sandwich fold | Descriptor: | PLATINUM (II) ION, Protein C10C5.1, isoform i | Authors: | Kamajaya, A, Kaiser, J, Lee, J, Reid, M, Rees, D.C. | Deposit date: | 2014-05-14 | Release date: | 2014-10-08 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The Structure of a Conserved Piezo Channel Domain Reveals a Topologically Distinct beta Sandwich Fold. Structure, 22, 2014
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3X3M
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![BU of 3x3m by Molmil](/molmil-images/mine/3x3m) | Crystal structure of EccB1 of Mycobacterium tuberculosis in spacegroup P212121 | Descriptor: | CALCIUM ION, ESX-1 secretion system protein EccB1 | Authors: | Zhang, X.L, Li, D.F, Zhang, X.E, Bi, L.J, Wang, D.C. | Deposit date: | 2015-01-24 | Release date: | 2015-12-09 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Core component EccB1 of the Mycobacterium tuberculosis type VII secretion system is a periplasmic ATPase. Faseb J., 29, 2015
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4PMH
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![BU of 4pmh by Molmil](/molmil-images/mine/4pmh) | The structure of rice weevil pectin methyl esterase | Descriptor: | Pectinesterase | Authors: | Stenkamp, R.E, Teller, D.C, Behnke, C.A, Reeck, G.R. | Deposit date: | 2014-05-21 | Release date: | 2014-11-12 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | The structure of rice weevil pectin methylesterase. Acta Crystallogr.,Sect.F, 70, 2014
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5V4G
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![BU of 5v4g by Molmil](/molmil-images/mine/5v4g) | Ruthenium(II)(cymene)(chlorido)2-lysozyme adduct with two binding sites | Descriptor: | Lysozyme C, PARA-CYMENE RUTHENIUM CHLORIDE, SODIUM ION | Authors: | Sullivan, M.P, Hartinger, C.G, Goldstone, D.C. | Deposit date: | 2017-03-09 | Release date: | 2017-04-05 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | The metalation of hen egg white lysozyme impacts protein stability as shown by ion mobility mass spectrometry, differential scanning calorimetry, and X-ray crystallography. Chem. Commun. (Camb.), 53, 2017
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5V86
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![BU of 5v86 by Molmil](/molmil-images/mine/5v86) | Structure of DCN1 bound to NAcM-OPT | Descriptor: | Lysozyme,DCN1-like protein 1, N-benzyl-N-(1-butylpiperidin-4-yl)-N'-(3,4-dichlorophenyl)urea | Authors: | Guy, R.K, Schulman, B.A, Scott, D.C, Hammill, J.T. | Deposit date: | 2017-03-21 | Release date: | 2017-05-24 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.374 Å) | Cite: | Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase. Nat. Chem. Biol., 13, 2017
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3WY7
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![BU of 3wy7 by Molmil](/molmil-images/mine/3wy7) | Crystal structure of Mycobacterium smegmatis 7-Keto-8-aminopelargonic acid (KAPA) synthase BioF | Descriptor: | 8-amino-7-oxononanoate synthase | Authors: | Fan, S.H, Li, D.F, Wang, D.C, Chen, G.J, Zhang, X.E, Bi, L.J. | Deposit date: | 2014-08-20 | Release date: | 2014-12-17 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure and function of Mycobacterium smegmatis 7-keto-8-aminopelargonic acid (KAPA) synthase Int.J.Biochem.Cell Biol., 58C, 2014
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5UW2
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5UW8
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![BU of 5uw8 by Molmil](/molmil-images/mine/5uw8) | |
4B2S
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![BU of 4b2s by Molmil](/molmil-images/mine/4b2s) | Solution structure of CCP modules 11-12 of complement factor H | Descriptor: | COMPLEMENT FACTOR H | Authors: | Makou, E, Mertens, H.D, Maciejewski, M, Soares, D.C, Matis, I, Schmidt, C.Q, Herbert, A.P, Svergun, D.I, Barlow, P.N. | Deposit date: | 2012-07-17 | Release date: | 2012-10-17 | Last modified: | 2013-05-08 | Method: | SOLUTION NMR | Cite: | Solution Structure of Ccp Modules 10-12 Illuminates Functional Architecture of the Complement Regulator, Factor H. J.Mol.Biol., 424, 2012
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5V88
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![BU of 5v88 by Molmil](/molmil-images/mine/5v88) | Structure of DCN1 bound to NAcM-COV | Descriptor: | Lysozyme,DCN1-like protein 1, N-{2-[({1-[(2R)-pentan-2-yl]piperidin-4-yl}{[3-(trifluoromethyl)phenyl]carbamoyl}amino)methyl]phenyl}propanamide | Authors: | Guy, R.K, Schulman, B.A, Scott, D.C, Hammill, J.T. | Deposit date: | 2017-03-21 | Release date: | 2017-05-24 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.601 Å) | Cite: | Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase. Nat. Chem. Biol., 13, 2017
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4U0I
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![BU of 4u0i by Molmil](/molmil-images/mine/4u0i) | Crystal structure of KIT in complex with ponatinib | Descriptor: | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, Mast/stem cell growth factor receptor Kit,Mast/stem cell growth factor receptor Kit, PHOSPHATE ION | Authors: | Zhou, T, Zhu, X, Dalgarno, D.C. | Deposit date: | 2014-07-11 | Release date: | 2014-10-08 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Ponatinib Inhibits Polyclonal Drug-Resistant KIT Oncoproteins and Shows Therapeutic Potential in Heavily Pretreated Gastrointestinal Stromal Tumor (GIST) Patients. Clin.Cancer Res., 20, 2014
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7JJ1
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![BU of 7jj1 by Molmil](/molmil-images/mine/7jj1) | |